122454-23-3

Basic information

• Product Name: 2-(4-Chlorophenyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile
• Synonyms: 2-(4-Chlorophenyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile
• CAS NO: 122454-23-3
• Molecular Formula: C₁₂H₆ClF₃N₂
• Molecular Weight: 270.64
• Mol File: 122454-23-3.mol

Chemical Properties

• Boiling Point: 414.233 °C at 760 mmHg
• Flash Point: 204.321 °C
• Appearance: /
• Density: 1.481 g/cm³
• CAS DataBase Reference: 2-(4-Chlorophenyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Chlorophenyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile(122454-23-3)
• EPA Substance Registry System: 2-(4-Chlorophenyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile(122454-23-3)

Safety Data

• Hazardous Substances Data: 122454-23-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-Chlorophenyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile is used as a building block for the synthesis of new drugs due to its biological activity. Its aromatic and fluorinated groups make it a valuable compound in drug discovery and development.
Used in Organic Chemistry:
In the field of organic chemistry, 2-(4-Chlorophenyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile is used for the development of new materials and compounds. Its unique structure and functional groups offer potential for creating novel organic molecules with specific properties.
Caution:
It is important to handle 2-(4-Chlorophenyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile with care, as its specific properties and potential hazards are not fully documented. Proper safety measures should be taken during its synthesis, storage, and use to minimize any risks associated with this compound.

Upstream product

• 431-35-6 3-bromo-1,1,1-trifluoroacetone 
• 107840-43-7 β-amino-β-(4-chlorophenyl)acrylonitrile 
• 421-50-1 1,1,1-trifluoro-2-propanone 
• 191548-91-1 β-amino-α-bromo-4-chlorocinnamonitrile 
• 920-37-6 2-Chloroacrylonitrile 
• 122460-66-6 4-(p-chlorophenyl)-2-(trifluoromethyl)-1,3-oxazol-5-one 
• 623-03-0 4-Cyanochlorobenzene 
• 6674-22-2 1,8-diazabicyclo[5.4.0]undec-7-ene 
• 107-13-1 acrylonitrile 
• 151680-55-6 β-amino-α-bromo-p-chlorocinnamonitrile 
• 167024-72-8 N-[(p-chlorophenyl)cyanomethyl]-2,2,2-trifluoroacetamide 
• 75-36-5 acetyl chloride 
• 6212-33-5 2-(4-Chlorophenyl)glycine 
• 2601-89-0 2,3-dichloropropionitrile 

Downstream Products

• 122454-29-9 tralopyril 
• 890929-76-7 4-bromo-1-((chloromethoxy)methyl)-2-(4-chlorophenyl)-5-(trifluoromethyl)pyrrole-3-carbonitrile 
• 890929-79-0 4-bromo-2-(4-chlorophenyl)-1-((2-(methylthio)ethoxy)methyl)-5-(trifluoromethyl)pyrrole-3-carbonitrile 
• 890929-78-9 4-bromo-1-((2-chloroethoxy)methyl)-2-(4-chlorophenyl)-5-(trifluoromethyl)pyrrole-3-carbonitrile 
• 890929-85-8 4-bromo-2-(4-chlorophenyl)-1-((2-(methylsulfinyl)ethoxy)methyl)-5-(trifluoromethyl)pyrrole-3-carbonitrile 
• 890929-86-9 4-bromo-2-(4-chlorophenyl)-1-((2-(methylsulfonyl)ethoxy)methyl)-5-(trifluoromethyl)pyrrole-3-carbonitrile 
• 890929-87-0 4-bromo-1-((3-chloropropoxy)methyl)-2-(4-chlorophenyl)-5-(trifluoromethyl)pyrrole-3-carbonitrile 
• 890929-80-3 4-bromo-2-(4-chlorophenyl)-1-((2-fluoroethoxy)methyl)-5-(trifluoromethyl)pyrrole-3-carbonitrile 
• 890929-81-4 4-bromo-1-((2-bromoethoxy)methyl)-2-(4-chlorophenyl)-5-(trifluoromethyl)pyrrole-3-carbonitrile 
• 122453-73-0 chlorfenapyr 
• 144032-68-8 N-((3-bromo-5-(4-chlorophenyl)-4-cyano-2-(trifluoromethyl)-1H-pyrrol-1-yl) methyl) acetamide 
• 143210-04-2 4-Bromo-1-(bromomethyl)-2-(p-chlorophenyl)-5-(trifluoromethyl)pyrrole-3-carbonitrile 
• 143464-11-3 4-chloro-2-(p-chlorophenyl)-5-(trifluoromethyl)-pyrrole-3-carbonitrile 

Relevant articles and documents

Preparation method of trobiglide

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Evaluation of the molluscicidal activities of arylpyrrole on Oncomelania hupensis, the intermediate host of Schistosoma japonicum

The snail Oncomelania hupensis is the only intermediate host of the highly invasive parasite Schistosoma japonicum. Molluscicide is often used to curb transmission of S. japonicum. Niclosamide, the only World Health Organization (WHO) recognized molluscicide, presents major drawbacks, including high cost and toxicity towards aquatic animals. In the present study, a number of aryl pyrrole derivatives (ADs) were synthesized to serve as potential molluscicides and were tested on O. hupensis. To uncover the underlying mechanisms, adenosine triphosphate (ATP) and adenosine diphosphate (ADP) levels were assessed in the soft body of ADs-exposed O. hupensis, using high performance liquid chromatography (HPLC). The effect of C6 on key points of energy metabolism (the activities of complexes I, III, IV and the membrane potential) was determined. We demonstrated that the Compound 6 (C6, 4-bromo-1-(bromomethyl)-2-(4-chlorophenyl)-5- (trifluoromethyl)-1H-pyrrole-3-carbonitrile) exerted the strongest molluscicidal activity against adult O. hupensis at LC50 of 0.27, 0.19, and 0.13 mg/L for 24, 48, and 72 h respectively. Moreover, we found that the bromide on the pyrrole ring of C6 was essential for molluscicidal activity. Furthermore, the ATP content reduced from 194.46 to 139.75 mg/g after exposure to 1/2 LC50, and reduced to 93.06 mg/g after exposure to LC50. ADP, on the other hand, remained the same level before and after C6 exposure. We found that C6, at 1/2 LC50, reduced the membrane potential of O. hupensis, while no significant changes were observed in the activities of complexes I, III, and IV. C6 was identified with excellent activities on O. hupensis. The obtained structure-activity relationship and action mechanism study results should be useful for further compound design and development.

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Application of 2-aryl substituted pyrrole compound in medicine for killing biomphalarid snails

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PRODUCTION OF ARYLPYRROL COMPOUNDS IN THE PRESENCE OF DIPEA BASE

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To search for novel 2-arylpyrroles with unique biological activities, a series of novel 2-arylpyrrole derivatives were designed and synthesized, and their structures were characterized by 1H and 13C NMR spectroscopy, MS spectrometry, and elemental analysis. Their insecticidal activities against Lepidopteran pests (e.g. Mythimna separata) and acaricidal activities against mites (e.g. Tetranychus urticae) were evaluated. The results of bioassays indicate that some of these title compounds exhibited excellent insecticidal and acaricidal activities. For example, 4-bromo-1-((chloromethoxy) methyl)-2-(4-chloro phenyl)-5-(trifluoromethyl)pyrrole-3-carbonitrile (6a), 4-bromo-2-(4-chlorophenyl)-1-((2-fluoroethoxy)-methyl)-5-(trifluoromethyl) pyrrole-3-carbonitrile (6d) showed insecticidal activity against Mythimna separata and 4-bromo-2-(4-chlorophenyl)-1-((isopropoxymethoxy)methyl)-5- (trifluoro methyl)pyrrole-3-carbonitrile (7d) showed acaricidal activity against Tetranychus urticae. They were more effective than Chlorfenapyr, which has been the only commercialized member of a new class of chemicals of 2-arylpyrroles.

Process for the preparation of 2-aryl-5-(perfluoro-alkyl) pyrrole compounds from N-[1-chloro-1-(perfluoroalkyl) methyl] arylimidoyl chloride compounds

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