1228780-51-5

Basic information

• Product Name: (2-(4-chlorophenyl)-4,4-diMethylcyclohex-1-enyl)Methanol
• Synonyms: (2-(4-chlorophenyl)-4,4-diMethylcyclohex-1-enyl)Methanol;2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexene-1-methanol;(4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methanol;1-Cyclohexene-1-methanol, 2-(4-chlorophenyl)-4,4-dimethyl-
• CAS NO: 1228780-51-5
• Molecular Formula: C₁₅H₁₉ClO
• Molecular Weight: 250.76376
• Mol File: 1228780-51-5.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 359.0±35.0 °C(Predicted)
• Appearance: /
• Density: 1.095±0.06 g/cm3(Predicted)
• PKA: 14.85±0.10(Predicted)
• CAS DataBase Reference: (2-(4-chlorophenyl)-4,4-diMethylcyclohex-1-enyl)Methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2-(4-chlorophenyl)-4,4-diMethylcyclohex-1-enyl)Methanol(1228780-51-5)
• EPA Substance Registry System: (2-(4-chlorophenyl)-4,4-diMethylcyclohex-1-enyl)Methanol(1228780-51-5)

Safety Data

• Hazardous Substances Data: 1228780-51-5(Hazardous Substances Data)

Usage

General Description

The chemical (2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)methanol is a compound with a molecular formula C15H19ClO. It is a derivative of cyclohexene and contains a chlorine atom attached to a phenyl group. (2-(4-chlorophenyl)-4,4-diMethylcyclohex-1-enyl)Methanol is a white solid at room temperature and is often used in organic synthesis and medicinal chemistry. It may also have potential applications in the field of pharmaceuticals or as a building block in the synthesis of other organic compounds. Its chemical properties and potential uses make it a subject of interest for researchers and chemists.

Upstream product

• 637-87-6 1-Chloro-4-iodobenzene 
• 195062-61-4 4-chlorophenylboronic acid pinacol ester 
• 1228943-80-3 2-chloro-4,4-dimethyl-2-oxocyclohexenecarbaldehyde 
• 1228837-05-5 4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbaldehyde 
• 251980-67-3 2-bromo-4,4-dimethylcyclohex-1-ene-1-carbaldehyde 
• 2979-19-3 3,3-dimethylcyclohexanone 
• 1679-18-1 4-Chlorophenylboronic acid 
• 1228780-46-8 methyl 4,4-dimethyl-2-(((trifluoromethyl)sulfonyl)oxy)cyclohex-1-ene-1-carboxylate 
• 32767-46-7 methyl 4,4-dimethyl-2-oxocyclohexancarboxylate 
• 1228780-49-1 4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carboxylic acid methyl ester 

Downstream Products

• 1228780-55-9 methyl 2-bromo-4-(4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl]piperazin-1-yl)benzoate 
• 1228837-05-5 4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbaldehyde 
• 1228780-72-0 1-((4’-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1‘-biphenyl]-2-yl)methyl)piperazine 
• 1235865-76-5 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4’-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1’-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid methyl ester 
• 1235865-77-6 [2-((1H-pyrrolo [2,3-b]pyridin-5-yl)oxy)-4-(4-((4’-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1’-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid] 
• 1257044-40-8 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide 

Relevant articles and documents

BCL-2 INHIBITORS AND THEIR USE AS PHARMACEUTICALS

The disclosure is directed to, in part, to BCL-2 inhibitors, pharmaceutical compositions comprising the same, as well as methods of their use and preparation.

1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES AS BCL-2 INHIBITORS FOR THE TREATMENT OF NEOPLASTIC AND AUTOIMMUNE DISEASES

The present invention relates to lH-pyrrolo[2,3-b]pyridine derivatives and related compounds as BCL-2 inhibitors for treating neoplastic, autoimmune or neurodegenerative diseases. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 162 to 233; examples 1 to 8; table; compound examples cpd-1 to cpd-135; biological examples 1 to 4).

BCL-2 INHIBITORS

The disclosure includes compounds of Formula (A), (A) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, and R11, h, j, m, n, k, v, s, g, V, W, L, Z1, Q1, Q2, Q3, Q4, Q5, Q6, and Q7, are defined herein. Also disclosed is a method for treating a neoplastic disease, an autoimmune disease, or a neorodegenerative disease with these compounds.