124156-21-4Relevant articles and documents
Enantioselective aerobic oxidative cross-dehydrogenative coupling of glycine derivatives with ketones and aldehydes: Via cooperative photoredox catalysis and organocatalysis
Li, Ying,Xie, Zhixiang,Yang, Xiaorong,Zhang, Yuan
, p. 4741 - 4746 (2020)
The combination of photoredox catalysis and enamine catalysis has enabled the development of an enantioselective aerobic oxidative cross-dehydrogenative coupling between glycine derivatives and simple ketones or aldehydes, which provides an efficient appr
Asymmetric autocatalytic Mannich reaction in the presence of water and its implication in prebiotic chemistry
Amedjkouh, Mohamed,Brandberg, Maria
, p. 3043 - 3045 (2008)
An enantioselective process in which the chiral Mannich product acts as a catalyst for its own replication was observed to occur under various conditions in the presence of water. The Royal Society of Chemistry.
Diastereoselective Hydrolysis of Branched Malonate Diesters by Porcine Liver Esterase: Synthesis of 5-Benzyl-Substituted Cα-Methyl-β-proline and Catalytic Evaluation
Kotapati, Hari Kiran,Robinson, Jamarii D.,Lawrence, Daniel R.,Fortner, Kimberly R.,Stanford, Caleb W.,Powell, Douglas R.,Wardenga, Rainer,Bornscheuer, Uwe T.,Masterson, Douglas S.
, p. 3009 - 3016 (2017)
Malonate diesters with highly branched side chains containing a preexisting chiral center were prepared from optically pure amino alcohols and subjected to asymmetric enzymatic hydrolysis by Porcine Liver Esterase (PLE). Recombinant PLE isoenzymes have be
Metal-free one-pot synthesis of quinoline-2,4-carboxylates via a molecular iodine-catalyzed three-component reaction of arylamines, ethyl glyoxylate, and α-ketoesters
Nan, Guang-Ming,Liu, Wei
, p. 1289 - 1292 (2015)
A simple and metal-free method has been developed for the construction of quinoline-2,4-carboxylates under mild conditions via a molecular iodine-catalyzed three-component tandem reaction of arylamines, ethyl glyoxylate, and α-ketoesters. The present prot
Visible light-induced aerobic oxidative cross-coupling of glycine esters with α-angelicalactone: a facile pathway to γ-lactams
Zhou, Huang,Yang, Xiaorong,Li, Shilin,Zhu, Yin,Li, Ying,Zhang, Yuan
, p. 6728 - 6734 (2018)
A metal-free aerobic oxidative dehydrogenative formal [2 + 3] cyclization of glycine esters with α-angelicalactone has been accomplished via the synergistic combination of photoredox catalysis and acid catalysis. This protocol provides straightforward and facile access to a series of substituted γ-lactams at room temperature under an air atmosphere. Moreover, the reaction could be carried out on a gram scale. The mild conditions as well as the use of cheap substrates and catalyst make this protocol very attractive for further synthetic applications.
Visible Light-Induced Aerobic Oxidative Csp3 ?H Arylation of Glycine Derivatives
Li, Shilin,Yang, Xiaorong,Wang, Yunwei,Zhou, Huang,Zhang, Boyang,Huang, Ganxing,Zhang, Yuan,Li, Ying
, p. 4452 - 4456 (2018)
A direct aerobic oxidative dehydrogenative coupling reaction of glycine derivatives with electron-rich arenes has been accomplished via the synergistic combination of organic-dye mediated photoredox catalysis and Lewis acid catalysis. This process exhibit
Asymmetric synthesis of piperidines using the nitro-Mannich reaction☆
Anderson, James C.,Bouvier-Israel, Eva,Rundell, Christopher D.,Zhang, Xiangyu
, (2020/12/21)
A method for the synthesis of functionalized piperidines containing 3 contiguous stereocentres in the 2-,3- and 4- positions uses a diastereoselective nitro-Mannich to control stereochemistry. The nitro-Mannich reaction between a β-aryl/heteroaryl substituted nitroalkanes and glyoxylate imine provides β-nitro-amines with good selectivity (70:30 to >95:5) for the syn, anti-diastereoisomers. Reductive cyclisation with BF3.OEt2 and Et3SiH gave, after purification, stereochemically pure piperidines in 19–57% yield for ten examples with different 4-aryl/heteroaryl substituents.
Dehydrogenative Aza-[4 + 2] Cycloaddition of Amines with 1,3-Dienes via Dual Catalysis
Chen, Xiaoxiao,Zhang, Guoxiang,Zeng, Rong
supporting information, p. 7144 - 7149 (2021/09/14)
We describe a synergistic utilization of copper catalysis and proton-transfer catalysis that enables an atom- and step-economical aza-[4 + 2] cycloaddition reaction of readily available N-arylamino carbonyl compounds with simple 1,3-dienes. The reaction p
