13303-10-1

Basic information

• Product Name: T -BUTYL-P-NITROPHENYL CARBONATE
• Synonyms: tert-butyl p-nitrophenyl carbonate;CARBONIC ACID TERT-BUTYL ESTER 4-NITRO-PHENYL ESTER;Carbonic acid (4-nitrophenyl)tert-butyl ester;Carbonic acid 1,1-dimethylethyl 4-nitrophenyl ester;Carbonic acid O-(4-nitrophenyl)O-tert-butyl ester;Carbonic acid tert-butyl 4-nitrophenyl ester;Carbonic acid tert-butyl(4-nitrophenyl) ester;Einecs 236-328-8
• CAS NO: 13303-10-1
• Molecular Formula: C₁₁H₁₃NO₅
• Molecular Weight: 239.22462
• EINECS: 236-328-8
• Product Categories: Aromatics Compounds;Aromatics;Isotope Labeled Compounds
• Mol File: 13303-10-1.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 345.7°Cat760mmHg
• Flash Point: 147.8°C
• Appearance: /
• Density: 1.227g/cm³
• Vapor Pressure: 6.04E-05mmHg at 25°C
• Refractive Index: 1.525
• CAS DataBase Reference: T -BUTYL-P-NITROPHENYL CARBONATE(CAS DataBase Reference)
• NIST Chemistry Reference: T -BUTYL-P-NITROPHENYL CARBONATE(13303-10-1)
• EPA Substance Registry System: T -BUTYL-P-NITROPHENYL CARBONATE(13303-10-1)

Safety Data

• Hazardous Substances Data: 13303-10-1(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

InChI:InChI=1/C11H13NO5/c1-11(2,3)17-10(13)16-9-6-4-8(5-7-9)12(14)15/h4-7H,1-3H3

Upstream product

• 7693-46-1 4-Nitrophenyl chloroformate 
• 75-65-0 tert-butyl alcohol 
• 100-02-7 4-nitro-phenol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 264255-59-6 1-tert-butoxy-2-tert-butoxycarbonyl-1,2-dihydrophthalazine 
• 149411-91-6 N-benzyloxycarbonyl cytosine 
• 404586-94-3 1-(tert-butoxy)-2-(tert-butoxy)carbonyl-1,2-dihydroisoquinoline 
• 53639-36-4 C₁₂H₁₁N₃O₁₀ 

Downstream Products

• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 13139-16-7 N-(tert-butyloxycarbonyl)-L-isoleucine 
• 5068-28-0 (2R)-3-benzylsulfanyl-2-tert-butoxycarbonylamino-propionic acid 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 15761-38-3 L-N-Boc-Ala 
• 3744-87-4 N-t-butyloxycarbonyl-DL-alanine 
• 2488-18-8 N-((tert-butyloxy)carbonyl)-L-methionine p-nitrophenyl ester 
• 2900-27-8 2-(tert-butoxycarbonylamino)-2-phenylacetic acid 
• 99275-47-5 1-(tert-butyloxycarbonyl)-5-methoxyindole 
• 30925-18-9 2-tert-butoxycarbonylamino-succinic acid 1-benzyl ester 
• 14484-34-5 N^β-tert.-Butyloxycarbonyl-DL-α-hydrazino-β-phenyl-propionsaeure-ethylester 
• 34046-07-6 N-benzyloxycarbonyl-N-(2-t.butoxycarbonylaminoethyl)glycine 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Relevant articles and documents

Synthesis method of N-BOC-ethylenediamine

The invention provides a synthesis method of N-BOC-ethylenediamine. The synthesis method of the N-BOC-ethylenediamine is characterized in that ethylenediamine and tert-butyl (p-nitrophenyl) carbonate (namely a self-made compound A) are subjected to a reac

Development of potent and selective tissue transglutaminase inhibitors: Their effect on TG2 function and application in pathological conditions

Potent-selective peptidomimetic inhibitors of tissue transglutaminase (TG2) were developed through a combination of protein-ligand docking and molecular dynamic techniques. Derivatives of these inhibitors were made with the aim of specific TG2 targeting to the intra- and extracellular space. A cell-permeable fluorescently labeled derivative enabled detection of in situ cellular TG2 activity in human umbilical cord endothelial cells and TG2-transduced NIH3T3 cells, which could be enhanced by treatment of cells with ionomycin. Reaction of TG2 with this fluorescent inhibitor in NIH3T3 cells resulted in loss of binding of TG2 to cell surface syndecan-4 and inhibition of translocation of the enzyme into the extracellular matrix, with a parallel reduction in fibronectin deposition. In human umbilical cord endothelial cells, this same fluorescent inhibitor also demonstrated a reduction in fibronectin deposition, cell motility, and cord formation in Matrigel. Use of the same inhibitor in a mouse model of hypertensive nephrosclerosis showed over a 40% reduction in collagen deposition.

Mixed metal MgO-ZrO2 nanoparticle-catalyzed O-tert-Boc protection of alcohols and phenols under solvent-free conditions

An environmentally benign method for O-tert-Boc protection of alcohols and phenols catalyzed by MgO-ZrO2 nanoparticles under solvent-free conditions is described. A variety of phenols, alcohols (aliphatic and aromatic) were converted to corresponding O-tert-Boc products in good to excellent yield (50-95%). The present protocol is expedient, simple, and efficient under solvent-free conditions. The MgO-ZrO2 Nps are easily prepared from inexpensive precursors, and are reusable, recyclable and chemoselective. Copyright 2012 John Wiley & Sons, Ltd. Copyright