139022-25-6

Basic information

• Product Name: IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLIC ACID
• Synonyms: imidazo[2,1-f]pyridine-6-carboxylic acid;Imidazo[1,2-a]pyridine-6-carboxylicacid97%;IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLIC ACID;H-imidazo[1,2-a]pyridine-6-carboxylic acid;Imidazo[1,2-a]pyridine-6-carboxylic acid 97%;Imidazo[1,2-a]pyridine-6-...;6-Carboxyimidazo[1,2-a]pyridine;IMidazo[1,2-a]pyridine-6-carboxylic acid hydrochloride
• CAS NO: 139022-25-6
• Molecular Formula: C₈H₆N₂O₂
• Molecular Weight: 162.15
• Product Categories: blocks;Carboxes;Imidazoles;Pyridines;pharmacetical;Carboxylic Acids;Carboxylic Acids;Fused Ring Systems;Building Blocks;Imidazo[x,x-y]pyridine
• Mol File: 139022-25-6.mol

Chemical Properties

• Melting Point: 250
• Appearance: /
• Density: 1.41
• Refractive Index: 1.676
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 0.67±0.41(Predicted)
• CAS DataBase Reference: IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLIC ACID(139022-25-6)
• EPA Substance Registry System: IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLIC ACID(139022-25-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-43
• Safety Statements: 22-26-36/37/39-36/37
• HazardClass: IRRITANT
• Hazardous Substances Data: 139022-25-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Development:
IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLIC ACID is used as a scaffold structure for the synthesis of various pharmaceuticals, playing a crucial role in medicinal chemistry and drug design. Its unique structure allows for the development of compounds with a range of therapeutic applications.
Used in Medicinal Chemistry:
IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLIC ACID is used as a starting point for the creation of new bioactive molecules, contributing to the advancement of treatments for various diseases and conditions.
Used in Antiviral Applications:
IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLIC ACID is used as an antiviral agent, leveraging its bioactive properties to combat viral infections.
Used in Anti-inflammatory Applications:
IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLIC ACID is used as an anti-inflammatory agent, helping to reduce inflammation and alleviate symptoms associated with various inflammatory conditions.
Used in Anticancer Applications:
IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLIC ACID is used as an anticancer agent, exhibiting potential in the development of treatments for cancer due to its bioactive properties. It combines the properties of both imidazole and pyridine moieties, making it a valuable component in the fight against cancer.

InChI:InChI=1/C8H6N2O2/c11-8(12)6-1-2-7-9-3-4-10(7)5-6/h1-5H,(H,11,12)

Upstream product

• 136117-69-6 methyl 6-imidazo<1,2-a>pyridinecarboxylate 
• 3167-49-5 6-aminonicotinic acid 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 
• 1314777-15-5 imidazo[1,2-a]pyridin-6-carboxylic acid hydrochloride 
• 158001-04-8 imidazo[1,2-a]pyridine-6-carboxylic acid ethyl ester 
• 39658-41-8 ethyl-6-amino-nicotinate 
• 107-20-0 2-chloroethanal 
• 97-97-2 chloroacetaldehyde dimethyl acetal 
• 7252-83-7 1-bromo-2,2-dimethoxyethane 
• 36052-24-1 methyl 6-aminonicotinoate 

Downstream Products

• 1362148-89-7 N-(4-(5-(dimethylamino)pyrazin-2-ylsulfonyl)benzyl)imidazo[1,2-a]pyridine-6-carboxamide 
• 1362150-36-4 N-(4-((3-(trifluoromethoxy)phenyl)sulfonyl)benzyl)imidazo[1,2-a]pyrimidine-6-carboxamide 
• 1362142-40-2 N-(4-(1-isopropyl-1H-pyrazol-4-ylsulfonyl)benzyl)imidazo[1,2-a]pyridine-6-carboxamide 
• 1453176-75-4 4-{[(imidazo[1,2-a]pyridine-6-carbonyl)-amino]-methyl}-benzenesulfonyl chloride 
• 1453174-57-6 imidazo[1,2-a]pyridine-6-carboxylic acid 4-(4-pyrrolidin-1-ylpiperidine-1-sulfonyl)benzylamide 
• 1453173-85-7 imidazo[1,2-a]pyridine-6-carboxylic acid 4-[4-(2,2,2-trifluoroethyl)piperazine-1-sulfonyl]benzylamide 
• 1453176-74-3 imidazo[1.2-a]pyridine-6-carboxylic acid benzylamide 
• 1454284-73-1 imidazo[1,2-a]pyridine-6-carboxylic acid 4-(3-hydroxy-3-methylcyclobutanesulfonyl)benzylamide 
• 1454284-94-6 tert-butyl 3-fluoro-4-[[4-[(imidazo[1,2-a]pyridine-6-carbonylamino)methyl]phenyl]sulfonylamino]piperidine-1-carboxylate 
• 132213-07-1 6-(hydroxymethyl)imidazo[1,2-a]pyridine 
• 116355-16-9 6-imidazo<1,2-a>pyridinecarboxaldehyde 
• 1259603-82-1 (1S)-1-imidazo[1,2-a]pyridin-6-ylethanamine 
• 944905-12-8 1-(imidazo[1,2-a]pyridin-6-yl)ethanone 
• 1362147-37-2 N-{[4-(benzenesulfonyl)phenyl]methyl}imidazo[1,2-a]pyridine-6-carboxamide 

Relevant articles and documents

PROCESS FOR PREPARATION OF SAVOLITINIB AND ITS INTERMEDIATES

The present application relates to a process for preparation of chiral amine fragment (IV) of savolitinib. The present application also relates to a process for preparation of savolitinib using the chiral amine (IV), as prepared by the process of the present application. The present application also discloses new intermediates useful for the synthesis of savolitinib. The present application further relates to crystalline forms of savolitinib, namely AA1, formic acid solvate and AA2. The present application also relates to amorphous solid dispersion of savolitinib.

IMPROVED METHOD FOR THE MANUFACTURE OF 3-[(1S)-1-IMIDAZO[1,2-A]PYRIDIN-6-YLETHYL]-5-(1-METHYLPYRAZOL-4-YL)TRIAZOLO[4,5-B]PYRAZINE AND POLYMORPHIC FORMS THEREOF

This specification generally relates to an improved method for the manufacture of 3-[(lS)-l -imidazo[ 1,2-a]pyridin-6-ylethyl]-5-(l-methylpyrazol-4-yl)triazolo[4,5- bjpyrazine (I), or pharmaceutically acceptable salts thereof; polymorphic forms thereof; and intermediates useful in the manufacture of such compounds and salts thereof. Formula (I).

P2X3 AND/OR P2X2/3 COMPOUNDS AND METHODS

The present disclosure provides novel compounds and methods for preparing and using these compounds. In one embodiment, the compounds are of the structure of formula (I), wherein R1-R7 are defined herein. In a further embodiment, these compounds are useful in method for regulating one or both of the P2X3 or P2X2/3 receptors. In another embodiment, these compounds are useful for treating pain in patients by administering one or more of the compounds to a patient. In another embodiment, these compounds are useful for treating respiratory dysfunction in patients by administering one or more of the compounds to a patient.

SPIRO-OXADIAZOLINE COMPOUNDS AS AGONISTS OF α-7-NICOTINIC ACETYLCHOLINE RECEPTORS

The present invention relates to novel spiro-oxadiazoline compounds that are suitable as agonists or partial agonists of a7-nAChR, and pharmaceutical compositions of the same, methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering a spiro-oxadiazoline cx7-nAChR agonist or partial agonist, to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.

AMIDO-BENZYL SULFONE AND SULFOXIDE DERIVATIVES

The present invention relates to certain amido-benzyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

PYRIDINYL AND PYRIMIDINYL SULFOXIDE AND SULFONE DERIVATIVES

Disclosed are certain pyridinyl and pyrimidinyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds and methods of treatment using such compounds.

AMIDO-BENZYL SULFONE AND SULFONAMIDE DERIVATIVES

Disclosed are certain amido-benzyl sulfone and sulfonamide compounds, pharmaceutical compositions comprising such compounds, land methods of treatment using such compounds.

ALKYL-AND DI-SUBSTITUTED AMIDO-BENZYL SULFONAMIDE DERIVATIVES

The present invention relates to certain alkyl- and di-substituted amido-benzyl sulfonamide compounds, pharmaceutical compositions comprising such compounds, and to methods of treatment of NAMPT-mediated disorders, such as diabetes, rheumatoid arthritis,

AMIDO SPIROCYCLIC AMIDE AND SULFONAMIDE DERIVATIVES

Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

AMIDO-BENZYL SULFOXIDE DERIVATIVES

The present invention relates to certain amido-benzyl sulfoxide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment of an NAMPT-mediated disease or condition in a subject, selected from solid or liquid tumor, rheumat