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14257-84-2

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14257-84-2 Usage

Description

N-Acetyl-D-phenylglycine is a chemical compound derived from phenylglycine, an amino acid, with an acetyl group attached to the amino group. It serves as a building block for the synthesis of various pharmaceuticals and organic compounds, playing a significant role in the development of novel drugs and the production of a range of chemical products. Its pharmacological properties and potential therapeutic applications make it an important compound in the field of medicinal chemistry and drug development.

Uses

Used in Pharmaceutical Industry:
N-Acetyl-D-phenylglycine is used as a key building block for the synthesis of various pharmaceuticals, contributing to the development of novel drugs with improved therapeutic properties.
Used in Organic Chemistry:
N-Acetyl-D-phenylglycine is used as a versatile intermediate in the synthesis of a wide range of organic compounds, facilitating the creation of new chemical products with diverse applications.
Used in Medicinal Chemistry:
N-Acetyl-D-phenylglycine is utilized in the exploration of its pharmacological properties and potential therapeutic applications, aiding in the advancement of drug discovery and development processes.

Check Digit Verification of cas no

The CAS Registry Mumber 14257-84-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,2,5 and 7 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 14257-84:
(7*1)+(6*4)+(5*2)+(4*5)+(3*7)+(2*8)+(1*4)=102
102 % 10 = 2
So 14257-84-2 is a valid CAS Registry Number.

14257-84-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name (2R)-2-acetamido-2-phenylacetic acid

1.2 Other means of identification

Product number -
Other names N-acetyl-DL-phenylglycine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:14257-84-2 SDS

14257-84-2Relevant articles and documents

Reverse Micelles, an Alternative to Aqueous Medium for Microbial Reactions: Yeast-Mediated Resolution of α-Amino Acids in Reverse Micelles

Fadnavis, N. W.,Reddy, N. Prabhakar,Bhalerao, U. T.

, p. 3218 - 3221 (1989)

-

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Cohen et al.

, p. 5315,5319 (1966)

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O-Benzyl derivatives of (S)-(+) and (R)-(-)-2-aminobutan-1-ol as new resolving agents for racemic acids. Practical resolutions of N-acyl derivatives of phenylglycine and 4-hydroxyphenylglycine

Touet, Joel,Faveriel, Laurent,Brown, Eric

, p. 2957 - 2960 (1993)

Treatment of the readily available (S)-(+) and (R)-(-)-2-aminobutan-1-ol 1 with sodium hydride followed by benzyl chloride, or a substituted benzyl halide, afforded the corresponding O-benzyl bases 2-5 in high yields. These new bases are recommended for the large scale resolution of racemic acids. For instance, they proved efficient for the practical resolution of N-acetylphenylglycine (±)-7, N-acetyl-(4-hyroxylphenyl)glycine (±)-9 and N-chloroacetyl-(4-hydroxyphenyl) glycine (±)-10.

GRANZYME B DIRECTED IMAGING AND THERAPY

-

Page/Page column 82; 105, (2019/09/04)

Provided herein are heterocyclic compounds useful for imaging Granzyme B. Methods of imaging Granzyme B, combination therapies, and kits comprising the Granzyme B imaging agents are also provided.

Regiodivergent Enantioselective γ-Additions of Oxazolones to 2,3-Butadienoates Catalyzed by Phosphines: Synthesis of α,α-Disubstituted α-Amino Acids and N,O-Acetal Derivatives

Wang, Tianli,Yu, Zhaoyuan,Hoon, Ding Long,Phee, Claire Yan,Lan, Yu,Lu, Yixin

, p. 265 - 271 (2016/01/25)

Phosphine-catalyzed regiodivergent enantioselective C-2- and C-4-selective γ-additions of oxazolones to 2,3-butadienoates have been developed. The C-4-selective γ-addition of oxazolones occurred in a highly enantioselective manner when 2-aryl-4-alkyloxazol-5-(4H)-ones were employed as pronucleophiles. With the employment of 2-alkyl-4-aryloxazol-5-(4H)-ones as the donor, C-2-selective γ-addition of oxazolones took place in a highly enantioselective manner. The C-4-selective adducts provided rapid access to optically enriched α,α-disubstituted α-amino acid derivatives, and the C-2-selective products led to facile synthesis of chiral N,O-acetals and γ-lactols. Theoretical studies via DFT calculations suggested that the origin of the observed regioselectivity was due to the distortion energy that resulted from the interaction between the nucleophilic oxazolide and the electrophilic phosphonium intermediate.

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