14470-51-0

Basic information

• Product Name: 5,6-DIHYDROTHIENO[2,3-C]PYRIDIN-7(4H)-ONE
• Synonyms: 5,6-DIHYDROTHIENO[2,3-C]PYRIDIN-7(4H)-ONE;5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one;5,6-Dihydrothieno[2,3-c]pyridin-7(4H);4H,5H,6H,7H-thieno[2,3-c]pyridin-7-one
• CAS NO: 14470-51-0
• Molecular Formula: C₇H₇NOS
• Molecular Weight: 153.20158
• Mol File: 14470-51-0.mol

Chemical Properties

• Boiling Point: 417.127°C at 760 mmHg
• Flash Point: 206.071°C
• Appearance: /
• Density: 1.295g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.597
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5,6-DIHYDROTHIENO[2,3-C]PYRIDIN-7(4H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-DIHYDROTHIENO[2,3-C]PYRIDIN-7(4H)-ONE(14470-51-0)
• EPA Substance Registry System: 5,6-DIHYDROTHIENO[2,3-C]PYRIDIN-7(4H)-ONE(14470-51-0)

Safety Data

• Hazardous Substances Data: 14470-51-0(Hazardous Substances Data)

Usage

Uses

5,6-dihydrothieno[2,3-c]pyridin-7(4H)-one is a useful research chemical.

InChI:InChI=1/C7H7NOS/c9-7-6-5(1-3-8-7)2-4-10-6/h2,4H,1,3H2,(H,8,9)

Upstream product

• 14600-24-9 4,5-dihydrocyclopenta[b]thiophen-6-one oxime 
• 5650-52-2 4,5-dihydro-6H-cyclopenta[b]thiophen-6-one 
• 34843-84-0 2-(thiophen-3-yl)ethan-1-amine hydrochloride 
• 13781-53-8 (thiophen-3-yl)acetonitrile 
• 1195-52-4 3-(3-thienyl)-2-propenoic acid 
• 498-62-4 3-thiophene carboxaldehyde 
• 59311-67-0 2-(3-thienyl)ethylamine 
• 847140-00-5 C₇H₇NOS 
• 179061-06-4 N-tert-butoxycarbonyl-2-(3-thienyl)ethylamine 
• 16378-06-6 3-(3-thienyl)propanoic acid 
• 68559-67-1 6-acetyl-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one 
• 960289-02-5 (2-thiophen-3-yl-ethyl)-carbamic acid ethyl ester 

Downstream Products

• 960289-03-6 2-bromo-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one 
• 960289-08-1 2-(4-methoxy-phenyl)-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one 
• 960289-27-4 2-(4-chloro-phenyl)-6H-thieno[2,3-c]pyridin-7-one 
• 960402-40-8 6-(4-bromo-phenyl)-2-(4-chloro-phenyl)-6H-thieno[2,3-c]pyridin-7-one 
• 960400-65-1 6-(4-hydroxy-3-methoxy-phenyl)-2-(4-methoxy-phenyl)-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one 
• 960401-13-2 2-methoxy-4-[2-(4-methoxy-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-benzoic acid methyl ester 
• 960401-15-4 2-methoxy-4-[2-(4-methoxy-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-benzoic acid 
• 960402-73-7 (+/-)-pyrrolidine-3-carboxylic acid {4-[2-(4-chloro-phenyl)-7-oxo-7H-thieno[2,3-c]pyridin-6-yl]-phenyl}-amide 
• 960401-12-1 trifluoromethanesulfonic acid 2-methoxy-4-[2-(4-methoxy-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-phenyl ester 

Relevant articles and documents

FUSED THIOPHENE AND THIAZOLE DERIVATIVES AS ROR GAMMA MODULATORS

The present invention provides fused thiophene and thiazole derivatives of formula (I), which may be therapeutically useful, more particularly as RORγ modulators; in which R1, R2, R3, R4, R5, R6, R7, X1, X2, L, m, n and ring A have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention of diseases or disorders, in particular their use in disease(s) or disorder(s) where there is an advantage in modulating RORγ receptor. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the fused thiophene and thiazole derivatives of formula (I), together with a pharmaceutically acceptable carrier, diluent or excipient therefor.

17a-HYDROXYLASE/C17,20-LYASE INHIBITORS

The present invention provides compounds of Formula (I), or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, A and n are as defined herein. A deuteriated derivative of the compound of Formula (I) is also provided.

Synthesis of 3,4-dihydroisoquinolin-1-ones from N-Boc-(β-Arylethyl) carbamates via isocyanate intermediates

Mild reaction conditions for the regioselective synthesis of isoquinolin-1-ones and related fused-ring heterocycles from N-Boc-protected (β-arylethyl)carbamates are described. The reactions involved the use of Tf2O and 2-chloropyridine and isocyanates are likely to be key intermediates. The method was extended to substrates bearing less nucleophilic aryl moieties by using Lewis acid additives, such as BF3· Et2O, to enhance the Friedel-Crafts-type cyclization of the isocyanate intermediates. This method allowed the synthesis of various substituted isoquinolin-1-ones, β-carbolines, thiophene-fused ring systems and tetrahydrobenzoazepin-1-ones in good yields and with high regioselectivities. Copyright

MST1 KINASE INHIBITORS AND METHODS OF THEIR USE

Compounds for the inhibition of mammalian Ste20-like kinase 1 (MST1) are disclosed, along with compositions comprising them and methods of their use in the treatment, management or prevention of an inflammatory or autoimmune diseases or disorders.

17α-HYDROXYLASE/C17,20-LYASE INHIBITORS

The present invention provides compounds of Formula (I), or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, A and n are as defined herein. A deuteriated derivative of the compound of Formula (I) is also provided.

NOVEL MCH RECEPTOR ANTAGONISTS

The present invention relates to a melanin concentrating hormone antagonist compound of formula (I): wherein R1, Ra, Rb, R2, L1, R3, R4 and R5 are as defined, or a pharmaceutically acceptable salt, enantiomer, diastereomer or mixture of diasteromers thereof useful in the treatment, obesity and related diseases.

NOVEL MCH RECEPTOR ANTAGONISTS

The present invention relates to a melanin concentrating hormone antagonist compound of formula (I): wherein R1, Ra, Rb, R2, L1, R3, R4 and R5 are as defined, or a pharmaceutically acceptable salt, enantiomer, diastereomer or mixture of diasteromers thereof useful in the treatment, obesity and related diseases.

Thieno[2,3-c] and [3,2-c]pyridines, process for their preparation and therapeutic applications thereof

This invention relates to compounds having the formulae STR1 in which: R1 represents hydrogen, a halogen atom or a lower alkyl radical, a lower alkoxy radical or a lower alkylthio radical; R2 represents hydrogen or a lower alkyl, ara