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2-Fluoro-6-methoxybenzaldehyde is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 146137-74-8 Structure
  • Basic information

    1. Product Name: 2-Fluoro-6-methoxybenzaldehyde
    2. Synonyms: RARECHEM AK VD 0022;6-FLUORO-O-ANISALDEHYDE;2-FLUORO-6-METHOXYBENZALDEHYDE;2-METHOXY-6-FLUOROBENZALDEHYDE;Benzaldehyde, 2-fluoro-6-methoxy- (9CI);2-Fluoro-6-mehoxybenzaldehyde;2-Fluoro-6-methoxybenzaldehyde 99%;2-Fluoro-6-methoxybenzaldehyde99%
    3. CAS NO:146137-74-8
    4. Molecular Formula: C8H7FO2
    5. Molecular Weight: 154.14
    6. EINECS: 1312995-182-4
    7. Product Categories: HALIDE;ALDEHYDE;Aromatic Aldehydes & Derivatives (substituted)
    8. Mol File: 146137-74-8.mol
  • Chemical Properties

    1. Melting Point: 59-63 °C(lit.)
    2. Boiling Point: 218.5 °C at 760 mmHg
    3. Flash Point: >230 °F
    4. Appearance: White to tan/5 wt.% in methanol
    5. Density: 0.807 g/mL at 25 °C
    6. Vapor Pressure: 0.011mmHg at 25°C
    7. Refractive Index: n20/D 1.339
    8. Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
    9. Solubility: N/A
    10. Sensitive: Air Sensitive
    11. CAS DataBase Reference: 2-Fluoro-6-methoxybenzaldehyde(CAS DataBase Reference)
    12. NIST Chemistry Reference: 2-Fluoro-6-methoxybenzaldehyde(146137-74-8)
    13. EPA Substance Registry System: 2-Fluoro-6-methoxybenzaldehyde(146137-74-8)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 36/37/38
    3. Safety Statements: 26-36
    4. RIDADR: UN 1230 3/PG 2
    5. WGK Germany: 3
    6. RTECS:
    7. HazardClass: IRRITANT
    8. PackingGroup: N/A
    9. Hazardous Substances Data: 146137-74-8(Hazardous Substances Data)

146137-74-8 Usage

Chemical Properties

off-white crystalline

Check Digit Verification of cas no

The CAS Registry Mumber 146137-74-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,6,1,3 and 7 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 146137-74:
(8*1)+(7*4)+(6*6)+(5*1)+(4*3)+(3*7)+(2*7)+(1*4)=128
128 % 10 = 8
So 146137-74-8 is a valid CAS Registry Number.
InChI:InChI=1/C7H4FIO/c8-7-2-1-6(9)3-5(7)4-10/h1-4H

146137-74-8 Well-known Company Product Price

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  • Alfa Aesar

  • (H26086)  2-Fluoro-6-methoxybenzaldehyde, 98%   

  • 146137-74-8

  • 250mg

  • 505.0CNY

  • Detail
  • Alfa Aesar

  • (H26086)  2-Fluoro-6-methoxybenzaldehyde, 98%   

  • 146137-74-8

  • 1g

  • 985.0CNY

  • Detail

146137-74-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Fluoro-6-methoxybenzaldehyde

1.2 Other means of identification

Product number -
Other names 2-fluoro-6-methoxy benzaldehyde

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:146137-74-8 SDS

146137-74-8Relevant articles and documents

List fluoro Radicamine compounds and their use and preparation method

-

Paragraph 0086-0088, (2017/12/02)

The invention discloses a mono-fluorinated Radicamine compound which has a structure as shown in a formula (1), and further provides a preparation method for the mono-fluorinated Radicamine compound with the structure as shown in the formula (1) and an application of the mono-fluorinated Radicamine compound or the mono-fluorinated Radicamine compound prepared with the method to preparation of drugs for preventing and/or treating diabetes, drugs for preventing and/or treating Gaucher's diseases, drugs for preventing and/or treating tumors or antiviral drugs. The mono-fluorinated Radicamine compound provided by the invention is good in glycosidase inhibition activity.

Discovery of New 2-[(4,6-Dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(substituted phenoxy)benzoic Acids as Flexible Inhibitors of Arabidopsis thaliana Acetohydroxyacid Synthase and Its P197L Mutant

Qu, Ren-Yu,Yang, Jing-Fang,Devendar, Ponnam,Kang, Wei-Ming,Liu, Yu-Chao,Chen, Qiong,Niu, Cong-Wei,Xi, Zhen,Yang, Guang-Fu

, p. 11170 - 11178 (2018/01/10)

In the search for new antiresistance acetohydroxyacid synthase (AHAS, EC 2.2.1.6) inhibitors to combat weed resistance associated with AHAS mutations, a series of 2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(substituted phenoxy)benzoic acids 11-38 were de

Fluorinated Radicamine A and B: Synthesis and Glycosidase Inhibition

Li, Yi-Xian,Iwaki, Ren,Kato, Atsushi,Jia, Yue-Mei,Fleet, George W. J.,Zhao, Xuan,Xiao, Min,Yu, Chu-Yi

, p. 1429 - 1438 (2016/03/16)

Fluorinated derivatives of radicamine A and radicamine B have been synthesized from D-arabinose-derived cyclic nitrone. Structure-activity relationship studies showed that glycosidase inhibition of these fluorinated derivatives was significantly influenced by the position of the fluorine atom. C-7 or C-11 fluorination of the aromatic ring decreased α-glucosidase inhibition of the derivatives, whereas C-8 or C-10 fluorination preserved glycosidase inhibitory activities. Fluorinated derivatives of radicamine A and B have been synthesized from D-arabinose-derived cyclic nitrone. Structure-activity relationship studies revealed that glycosidase inhibition of these fluorinated derivatives was significantly influenced by the position of the fluorine atom.

The Key Role of the Nonchelating Conformation of the Benzylidene Ligand on the Formation and Initiation of Hoveyda-Grubbs Metathesis Catalysts

Bieszczad, Bartosz,Barbasiewicz, Micha?

supporting information, p. 10322 - 10325 (2015/07/07)

Experimental studies of Hoveyda-Grubbs metathesis catalysts reveal important consequences of substitution at the 6-position of the chelating benzylidene ligand. The structural modification varies conformational preferences of the ligand that affects its exchange due to the interaction of the coordinating site with the ruthenium center. As a consequence, when typical S-chelated systems are formed as kinetic trans-Cl2 products, for 6-substituted benzylidenes the preference is altered toward direct formation of thermodynamic cis-Cl2 isomers. Activity data and reactions with tricyclohexylphosphine (PCy3) support also a similar scenario for O-chelated complexes, which display fast trans-Cl2?cis-Cl2 equilibrium observed by NMR EXSY studies. The presented conformational model reveals that catalysts, which cannot adopt the optimal nonchelating conformation of benzylidene ligand, initiate through a high-energy associative mechanism.

MULTIPLE KINASE PATHWAY INHIBITORS

-

Page/Page column 299-300, (2014/04/17)

Kinase with inhibitory activity against kinases disposed in multiple signaling pathways and their therapeutic uses.

Regioselective formylation of 1,3-disubstituted benzenes through in situ lithiation

Wang, Le,Wang, Yan,Guo, Fangxu,Zheng, Yue,Bhadury, Pinaki S.,Sun, Zhihua

supporting information, p. 6053 - 6056 (2013/10/22)

A facile method of regioselective formylation of disubstituted benzene via in situ deprotonation/metalation using n-BuLi/TMEDA/DIPA has been developed. Effect of different electron withdrawing and electron donating substituents in 1,3-interrelated aromatic system was studied; the metalation mostly occurred at the 2-position to afford the desired products in high yields.

NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES

-

Page/Page column 100, (2012/12/13)

The present invention provides PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.

NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES

-

Page/Page column 100; 101, (2012/11/14)

The present invention provides PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.

Pyrazolopyrimidines as therapeutic agents

-

, (2008/06/13)

The present invention is directed to pyrazolopyrimidine derivatives of formula (I) wherein the substituents are defined herein, which are useful as kinase inhibitors and as such are useful for affecting angiogenesis and diseases and conditions associated with angiogenesis.

4-Substituted (benzo[b]thiophene-2-carbonyl)guanidines as novel Na +/H+ exchanger isoform-1 (NHE-1) inhibitors

Lee, Sunkyung,Lee, Hyunsuk,Kyu, Yang Yi,Byung, Ho Lee,Yoo, Sung-Eun,Lee, Kyunghee,Nam, Sook Cho

, p. 2998 - 3001 (2007/10/03)

A series of 4-substituted (benzo[b]thiophene-2-carbonyl)guanidines was synthesized and evaluated for the NHE-1 inhibitory activity and cardioprotective efficacy both in vitro and in vivo. Several analogs exhibited a strong inhibition on NHE-1, and which was generally well correlated with their cardioprotective efficacy. Especially the 4-nitro 20 and cyano 50 compounds excellently improved the cardiac function and reduced infarct size against ischemia/reperfusion injury.

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