17342-08-4

Basic information

• Product Name: L-Pyroglutaminol
• Synonyms: 2-Pyrrolidinone, 5-(hydroxyMethyl)-, (5S)-;L-Pyr-OL;(S)-5-(Hydroxymethyl)-2-pyrrolidinone,99%e.e.;(S)-(+)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE;(S)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE;TIMTEC-BB SBB004302;PYROGLUTAMINOL;PGLU-OL
• CAS NO: 17342-08-4
• Molecular Formula: C₅H₉NO₂
• Molecular Weight: 115.13
• EINECS: -0
• Product Categories: pharmacetical;Pyrrolidine series;Heterocyclic Compounds;Amides (Chiral);Chiral Building Blocks;Synthetic Organic Chemistry;Heterocycles;Miscellaneous Reagents
• Mol File: 17342-08-4.mol
• Article Data: 69

Chemical Properties

• Melting Point: 79-80 °C(lit.)
• Boiling Point: 147-149°C 0,06mm
• Flash Point: 147-149°C/0.06m
• Appearance: White to light yellow/Crystals or Crystalline Powder
• Density: 1.1808 (rough estimate)
• Refractive Index: 31 ° (C=5, EtOH)
• Storage Temp.: Store at 0-5°C
• Solubility: DMSO, Ethanol, Methanol
• PKA: 14.35±0.10(Predicted)
• Water Solubility: Soluble in water.
• BRN: 4657914
• CAS DataBase Reference: L-Pyroglutaminol(CAS DataBase Reference)
• NIST Chemistry Reference: L-Pyroglutaminol(17342-08-4)
• EPA Substance Registry System: L-Pyroglutaminol(17342-08-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• F: 3-10
• Hazardous Substances Data: 17342-08-4(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystals or

Uses

(S)-Pyroglutaminol (cas# 17342-08-4) is a compound useful in organic synthesis.

Upstream product

• 56-86-0 L-glutamic acid 
• 7149-65-7 ethyl (S)-pyroglutamate 
• 4931-66-2 methyl (S)-pyroglutamate 
• 98-79-3 L-Pyroglutamic acid 
• 74936-93-9 (S)-5-oxopyrrolidine-2-carbonyl chloride 
• 6525-53-7 L-glutamic acid dimethyl ester 
• 4931-66-2 (S)-5-Hydroxy-3,4-dihydro-2H-pyrrole-2-carboxylic acid methyl ester 
• 1118-89-4 diethyl-L-glutamate hydrochloride 
• 142-47-2 glutamic acid sodium salt 

Downstream Products

• 141694-95-3 S-1-trimethylsilyl-5-trimethylsilyloxymethyl-2-pyrrolidinone 
• 170885-02-6 (S)-5-(trimethylsilyloxymethyl)-2-pyrrolidinone 
• 355387-81-4 (S)-N-(2,2'-biphenoxyphosphino)-2-(2,2'-biphenoxyphosphinoxymethyl)pyrrolidin-5-one 
• 515863-25-9 (S)-tert-butyl 2-(azidomethyl)-5-oxopyrrolidine-1-carboxylate 
• 533923-40-9 (S)-2-Azidomethyl-5-oxo-pyrrolidine-1-carboxylic acid benzyl ester 
• 533923-41-0 (3R,5S)-5-Azidomethyl-3-(tert-butyl-dimethyl-silanyloxy)-2-oxo-pyrrolidine-1-carboxylic acid benzyl ester 
• 533923-42-1 (3S,5S)-5-Azidomethyl-3-(tert-butyl-dimethyl-silanyloxy)-2-oxo-pyrrolidine-1-carboxylic acid benzyl ester 

Relevant articles and documents

INHIBITORS OF APOL1 AND METHODS OF USING SAME

The disclosure provides at least one entity chosen from compounds of formula (I), solid state forms of the same, compositions comprising the same, and methods of using the same, including use in treating focal segmental glomerulosclerosis (FSGS) and/or non-diabetic kidney disease (NDKD).

Biphenyl compound as well as preparation method and medical application thereof

The invention discloses a biphenyl compound as well as a preparation method and medical application thereof, the structure of the biphenyl compound is shown as a formula (I) or a formula (II), and thebiphenyl compound or pharmaceutically acceptable salt, tautomer, meso-isomer, raceme, stereoisomer, metabolite, metabolite precursor, prodrug or solvate thereof is a PD-L1 inhibitor. The compound hasa remarkable inhibiting effect on the interaction of PD-1 and PD-L1 protein, so that the compound can be applied to the preparation of PD-L1 inhibitors and immunomodulator drugs for preventing or treating tumors, autoimmune diseases, organ transplant rejection, infectious diseases and inflammatory diseases.

5-HT7 Receptor Antagonists with an Unprecedented Selectivity Profile

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