17609-80-2

Basic information

• Product Name: 4-Amino-3-chlorophenol
• Synonyms: AMINO(4-)-3-CHLOROPHENOL;4-AMINO-3-CHLOROPHENOL;3-chloro-4-aminophenol;4-amino-3-chloro-pheno;Brn 2802558;Einecs 241-583-3;Phenol, 4-amino-3-chloro-;lenvaint-G
• CAS NO: 17609-80-2
• Molecular Formula: C₆H₆ClNO
• Molecular Weight: 143.57
• EINECS: 241-583-3
• Mol File: 17609-80-2.mol

Chemical Properties

• Melting Point: 159-160℃
• Boiling Point: 287.3°Cat760mmHg
• Flash Point: 127.6°C
• Appearance: White/Crystalline Powder
• Density: 1.406g/cm³
• Vapor Pressure: 0.00074mmHg at 25°C
• Refractive Index: 1.606
• Storage Temp.: 2-8°C(protect from light)
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 9.26±0.18(Predicted)
• CAS DataBase Reference: 4-Amino-3-chlorophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-3-chlorophenol(17609-80-2)
• EPA Substance Registry System: 4-Amino-3-chlorophenol(17609-80-2)

Safety Data

• RTECS: SJ5710000
• HazardClass: 6.1
• Hazardous Substances Data: 17609-80-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Amino-3-chlorophenol is used as a synthetic reagent for the preparation of Benzothiazole-based ureas. These compounds have potential as modulators for ABAD/17β-HSD10, which are targets in the treatment of Alzheimer's disease. The development of such modulators can contribute to the advancement of therapeutic strategies for this neurodegenerative condition.

InChI:InChI=1S/C6H6ClNO/c7-5-3-4(9)1-2-6(5)8/h1-3,9H,8H2

Upstream product

• 3296-07-9 1-azido-2-chlorobenzene 
• 491-11-2 3-chloro-4-nitrophenol 
• 60144-85-6 4'-acetoxy-2'-chloroacetanilide 
• 88-73-3 2-Chloronitrobenzene 
• 10468-16-3 2-chloro-N-hydroxybenzenamine 
• 74993-54-7 O-(m-chloro-phenyl)-hydroxylamine 
• 20815-53-6 4-(4-chlorophenylazo)pyridine 
• 7664-93-9 sulfuric acid 
• 7758-99-8 copper(II) sulfate 
• 7647-01-0 hydrogenchloride 
• 67-66-3 chloroform 
• 2623-33-8 4-acetoxyacetanilide 
• 7782-50-5 chlorine 
• 123-30-8 4-amino-phenol 

Downstream Products

• 695-99-8 2-Chloro-1,4-benzoquinone 
• 88680-97-1 benzenesulfonic acid-(2-chloro-4-hydroxy-anilide) 
• 122267-40-7 2-chloro-4-[1,1,2-trifluoro-2-(trifluoromethoxy)-ethoxy]-aniline 
• 156079-10-6 4-[Bis-(2-hydroxy-ethyl)-amino]-3-chloro-phenol 
• 156079-17-3 2-[(4-Benzyloxy-2-chloro-phenyl)-(2-hydroxy-ethyl)-amino]-ethanol 
• 156079-23-1 (4-Benzyloxy-2-chloro-phenyl)-bis-(2-chloro-ethyl)-amine 
• 172974-06-0 Carbonic acid 4-[bis-(2-chloro-ethyl)-amino]-3-chloro-phenyl ester 4-nitro-phenyl ester 
• 172974-13-9 (S)-2-{4-[Bis-(2-chloro-ethyl)-amino]-3-chloro-phenoxycarbonylamino}-pentanedioic acid dibenzyl ester 
• 122267-38-3 N-2-chlorobenzoyl-N'-2-chloro-4-[1,1,2-trifluoro-2-(trifluoromethoxy)-ethoxy]-phenyl-urea 
• 122267-36-1 N-(2,6-difluorobenzoyl)-N'-2-chloro-4-[1,1,2-trifluoro-2-(trifluoromethoxy)-ethoxy]-phenyl-urea 
• 88681-00-9 N-(2-chloro-4-oxo-cyclohexa-2,5-dienylidene)-benzenesulfonamide 
• 56074-07-8 4-acetamido-3-chlorophenol 
• 18119-24-9 8-Chlor-6-hydroxychinolin 
• 796848-80-1 phenyl N-(2-chloro-4-hydroxyphenyl)carbamate 

Relevant articles and documents

Hydroxylation of aromatic amines with dioxygen in photooxidation sensitized by substituted phthalocyanines

Photooxidation of aniline and its methyl and chloro derivatives with dioxygen sensitized by substituted zinc (PcZn) and palladium (PcPd) phthalocyanines in solution and on the carrier surface upon visible light irradiation affords selectively the corresponding p-aminophenols. Active and the most stable PcPd derivative adsorbed on Amberlite XAD 7HP provides conversion of 2,6-dimethylaniline with selectivity over 90% without the loss of sensitizer activity at least in 8 repeated cycles, the overall turnover number of the sensitizer being greater than 25,000.

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The present invention relates to a tyrosine kinase inhibitor and a pharmaceutical composition comprising same. The tyrosine kinase inhibitor of the present invention has the structures as shown in the following formula (I) or (II):

Method for synthesizing 4-amino-3-chlorophenol by means of multiple-temperature-zone continuous flow microchannel reactor

The invention relates to a method for synthesizing 4-amino-3-chlorophenol by means of a multiple-temperature-zone continuous flow microchannel reactor, which belongs to the field of organic synthesisof anti-cancer drugs, and solves the problems in the prior art that in a process of synthesizing 4-amino-3-chlorophenol, the product yield is low, the purity is low, the cost is high and the safety property of the product is poor and the like as raw materials are not easily available, the catalyst is high in cost and the synthesized intermediate product is unstable in diazonium salt. By means of the microchannel reactor, sulfanilic acid is taken as an initial raw material, a target product 4-amino-3-chlorophenol is obtained by three steps of diazotization, coupling of diazonium salt and reduction of an azoic compound. The method provided by the invention can be applied to large-scale production of 4-amino-3-chlorophenol.

Synthesis method of important pharmaceutical and chemical intermediate 4-amino-3-chlorophenol

The present invention discloses a synthesis method of important pharmaceutical and chemical intermediate 4-amino-3-chlorophenol, and the method comprises the following steps: acetylation of p-aminophenol, triethylamine and an acylating agent to obtain 4-acetamino phenyl acetate shown as a formula I; chlorination of the formula I compound and a chlorinated reagent to obtain 4-acetamino-3-phenyl chloroacetate shown as a formula II; and reaction of the formula II compound and an alkali at 80-120 DEG C to obtain the 4-amino-3-chlorophenol. The preparation method has the advantages of easy availability of raw materials, low cost, mild condition, high process operability and controllability, high yield and no need of complex post-treatment to obtain the high-purity 4-amino-3-chlorophenol.

One step hair coloring compositions using salts

A hair coloring composition comprising the following two compositions which are mixed just prior to application to the hair: (a) a composition comprising a water-soluble peroxygen oxidizing agent; and (b) a composition comprising one or more oxidative hair coloring agents selected from the group consisting of an aromatic diamine, an amino phenol, a naphthol, a polyhydric phenol, a catechol and mixtures thereof; wherein the composition comprising one or more oxidative hair coloring agents further comprises al least one water soluble carbonate releasing salts; and optionally a water soluble ammonium salt, is described.

Transition metal complexes as dye forming catalysts in hair coloring compositions

A hair coloring composition comprising a first composition which comprises: (a) a dye forming transition metal salt or complex; which is first applied to the hair; and a second composition which comprises the following two compositions which are mixed just prior to application to the hair: (a) a composition comprising a water-soluble peroxygen oxidizing agent; and (b) a composition comprising one or more oxidative hair coloring agents selected from the group consisting of an aromatic diamine, an aminophenol, a polyhydric phenol a catechol and mixtures thereof.

Enhanced color deposition for hair with sequestering agents

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Hair colouring and conditioning compositions

A hair colouring and conditioning composition comprising: (a) a hair colouring agent; and (b) a hair conditioning agent; wherein the composition provides an Average Combing Index Value of greater than 1.2 as measured by the Combing Technical Test Method. The products can provide excellent hair colouring together with excellent conditioning, reduced hair damage, brittleness and dryness, and is convenient and easy to use.

Hair conditioning compositions and their use in hair colouring compositions

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HAIR COLORING COMPOSITIONS

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