192704-56-6Relevant articles and documents
A steroid compound derivative having, its preparation process and its use in the preparation of Eplerenone
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, (2020/05/05)
The invention relates to a canrenone derivative steroid compound, a preparation method and an application in the medicine field, and particularly relates to 7alpha-nitro methyl-11alpha,17beta-dihydroxy-3-oxo-17alpha-pregna-4-ene-21-carboxylic acid-gamma-lactone (a compound shown in formula 2), a preparation method and an application in eplerenone preparation. The key steps of the invention are that nitromethane is used as a nucleophilic reagent; the alpha-nitro methyl group is introduced to the C-7 position stereoselectively so as to further construct a carboxylic acid methyl ester structure with a C-7alpha position configuration of eplerenone; the method of the invention has the characteristics of short steps, mild conditions, and low cost.
A chemobiological synthesis of eplerenone
Wuts, Peter G. M.,Anderson, Andrew M.,Ashford, Scott W.,Goble, Michael P.,White, Michael J.,Beck, Doris,Gilbert, Ivan,Hrab
, p. 418 - 422 (2008/09/17)
This paper will describe an approach to the synthesis of eplerenone, which is being marketed for the treatment of hypertension. The synthesis begins with DHEA available from wild yams and uses a combination of microbiological and chemical transformations to build eplerenone. Georg Thieme Verlag Stuttgart.
Processes for preparing C-7 substituted steroids
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Page/Page column 4-6; 11-12, (2008/06/13)
This invention relates to processes for the preparation of novel 7-carboxy substituted steroid compounds of Formula I,