Products Categories
| CAS No.: | 192704-56-6 |
|---|---|
| Name: | 11-a-Hydroxy canrenone methyl ester |
| Article Data: | 6 |
| Cas Database | |
| Molecular Structure: | |
|
|
|
| Formula: | C24H32 O6 |
| Molecular Weight: | 416.514 |
| Synonyms: | 11a,17b-Dihydroxypregn-4-en-3-one 7a,21-dicarboxylic acid g-lactone methyl ester; 11a-Hydroxymexrenone |
| Density: | 1.27±0.1 g/cm3(Predicted) |
| Boiling Point: | 604.5±55.0 °C(Predicted) |
| PSA: | 89.90000 |
| LogP: | 2.96400 |
- 19271-19-3Methyl 6-fluoro-4-hydroxyquinoline-2-carboxylate
- 19271-90-0Acetic acid,2-[2-(1,1-dimethylethyl)phenoxy]-
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- 1927-25-9Homoserine
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- 209253-72-5
9α,11α-epoxy-17β-hydroxypregn-4-en-3-one-7α,21-dicarboxylic acid γ-lactone
- 74-88-4
methyl iodide
- 192704-56-6
11β,17β-dihydroxy-7α-methoxycarbonyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone
| Conditions | Yield |
|---|---|
| With potassium carbonate In acetone at 0 - 20℃; | 80% |
| With potassium carbonate at 0 - 20℃; | 4 g |
- 192704-54-4
4'S(4'α),7'α-hexadecahydro-11'α-hydroxy-10'β,13'β-dimethyl-3',5,20'-trioxospiro[furan-2(3H),17'β-[4,7]metheno(17H)cyclopenta[a]phenanthrene]-5'β(2'H)-carbonitrile
- 124-41-4
sodium methylate
- 192704-56-6
11β,17β-dihydroxy-7α-methoxycarbonyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone
| Conditions | Yield |
|---|---|
| Stage #1: 4'S(4'α),7'α-hexadecahydro-11'α-hydroxy-10'β,13'β-dimethyl-3',5,20'-trioxospiro[furan-2(3H),17'β-[4,7]metheno(17H)cyclopenta[a]phenanthrene]-5'β(2'H)-carbonitrile; sodium methylate for 20h; Heating / reflux; Stage #2: With hydrogenchloride In methanol; water | 78% |
- 67-56-1
methanol
- 192704-54-4
4'S(4'α),7'α-hexadecahydro-11'α-hydroxy-10'β,13'β-dimethyl-3',5,20'-trioxospiro[furan-2(3H),17'β-[4,7]metheno(17H)cyclopenta[a]phenanthrene]-5'β(2'H)-carbonitrile
- 124-41-4
sodium methylate
- 192704-56-6
11β,17β-dihydroxy-7α-methoxycarbonyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone
| Conditions | Yield |
|---|---|
| Heating / reflux; | 77% |
| With zinc(II) iodide |
- 865-33-8
potassium methanolate
- 192704-56-6
11β,17β-dihydroxy-7α-methoxycarbonyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone
| Conditions | Yield |
|---|---|
| In methanol at 62 - 115℃; Product distribution / selectivity; | 68% |
| With Methyl formate In methanol at 60 - 115℃; for 0.05 - 11.5h; Product distribution / selectivity; | 62.6% |
- 192704-54-4
4'S(4'α),7'α-hexadecahydro-11'α-hydroxy-10'β,13'β-dimethyl-3',5,20'-trioxospiro[furan-2(3H),17'β-[4,7]metheno(17H)cyclopenta[a]phenanthrene]-5'β(2'H)-carbonitrile
- 865-33-8
potassium methanolate
- 192704-56-6
11β,17β-dihydroxy-7α-methoxycarbonyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone
| Conditions | Yield |
|---|---|
| In methanol for 23.5h; Heating / reflux; | 2.98 g |
| Stage #1: 4'S(4'α),7'α-hexadecahydro-11'α-hydroxy-10'β,13'β-dimethyl-3',5,20'-trioxospiro[furan-2(3H),17'β-[4,7]metheno(17H)cyclopenta[a]phenanthrene]-5'β(2'H)-carbonitrile; potassium methanolate In methanol at 60℃; for 7.5h; Heating / reflux; Stage #2: With hydrogenchloride In methanol; water for 0.25h; | 25 - 27 g |
- 41020-65-9
Mexrenone
- 192704-56-6
11β,17β-dihydroxy-7α-methoxycarbonyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone
| Conditions | Yield |
|---|---|
| With Beuveria bassiana ATCC 7159 In water | |
| With Absidia coerula ATCC 6647 In water | |
| With Aspergillus niger ATCC 16888 In water |
- 192704-56-6
11β,17β-dihydroxy-7α-methoxycarbonyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone
- 124-63-0
methanesulfonyl chloride
- 192704-58-8
methyl hydrogen 17α-hydroxy-11α-(methylsulfonyl)oxy-3-oxopregn-4-ene-7α,21-dicarboxylate, γ-lactone
| Conditions | Yield |
|---|---|
| With triethylamine In dichloromethane at 10 - 15℃; for 2h; Reagent/catalyst; Temperature; Solvent; Inert atmosphere; | 97.7% |
| With triethylamine In dichloromethane at -5 - 5℃; for 1.5h; | 88% |
| With pyridine at 5 - 20℃; for 2h; | 85% |
- 192704-56-6
11β,17β-dihydroxy-7α-methoxycarbonyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone
- 95716-70-4
17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
| Conditions | Yield |
|---|---|
| With hexafluoropropene-diethylamine adduct; diethyl-(pentafluoro-propenyl)-amine In chloroform at 30℃; for 30h; Solvent; Temperature; Reagent/catalyst; | 90% |
| Stage #1: 11β,17β-dihydroxy-7α-methoxycarbonyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone With methanesulfonyl chloride; triethylamine In dichloromethane at 5℃; for 1h; Stage #2: With formic acid; potassium formate; acetic anhydride at 70 - 95℃; for 5 - 9h; | 77% |
| With 1H-imidazole; sulfuryl dichloride In tetrahydrofuran at -10 - 20℃; for 1.5h; | 71% |
- 192704-56-6
11β,17β-dihydroxy-7α-methoxycarbonyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone
B
- 192704-70-4
7-methyl hydrogen 17α-hydroxy-3-oxopregna-4,11-diene-7α,21-dicarboxylate, γ-lactone
C
- 95716-70-4
17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
| Conditions | Yield |
|---|---|
| Stage #1: 11β,17β-dihydroxy-7α-methoxycarbonyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone With methanesulfonyl chloride; triethylamine In dichloromethane at 0℃; for 1.41667h; Stage #2: With formic acid; potassium formate; acetic anhydride at 40 - 95℃; for 2h; | A 2.27 g B 3.72 g C 68.8% |
| Stage #1: 11β,17β-dihydroxy-7α-methoxycarbonyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone With sulfuryl dichloride In tetrahydrofuran at -70℃; for 0.5h; Stage #2: With 1H-imidazole In tetrahydrofuran at -70 - 20℃; for 2h; | |
| Stage #1: 11β,17β-dihydroxy-7α-methoxycarbonyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone With methanesulfonyl chloride; triethylamine In dichloromethane at -5 - 0℃; for 1.33333h; Stage #2: With sodium acetate; acetic anhydride; acetic acid In dichloromethane at 55 - 135℃; for 1.5 - 2h; |
- 192704-56-6
11β,17β-dihydroxy-7α-methoxycarbonyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone
- 192704-58-8
methyl hydrogen 17α-hydroxy-11α-(methylsulfonyl)oxy-3-oxopregn-4-ene-7α,21-dicarboxylate, γ-lactone
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