20232-39-7

Basic information

• Product Name: 6,7-Dimethoxy-3,4-dihydroisoquinoline hydrochloride
• Synonyms: 3,4-dihydro-6,7-dimethoxyisoquinolinehydrochloride;3,4-dihydro-6,7-dimethoxy-isoquinolinhydrochloride;6,7-DIMETHOXY-3,4-DIHYDROISOQUINOLINE HYDROCHLORIDE;6,7-Dimethoxy-3,4-dihydroisoquinoline hydrochloride hydrate;6,7-Dimethoxy-3,4-dihydroisoquinolineHClhydrate;6,7-DIMETHOXY-3,4-DIHYDROISOQUINOLINE HYDROCHLORIDE HYDRATE 99+%;6,7-Dimethoxy-3,4-dihydroisoquinolin-2-ium chloride;6,7-Dimethoxy-3,4-dihydroisoquinoline, HCl
• CAS NO: 20232-39-7
• Molecular Formula: C₁₁H₁₃NO₂*ClH
• Molecular Weight: 227.69
• EINECS: 213-573-9
• Product Categories: API intermediates;Building Blocks/Intermediates
• Mol File: 20232-39-7.mol

Chemical Properties

• Melting Point: 198-202 °C
• Boiling Point: 322.9 °C at 760 mmHg
• Flash Point: 122 °C
• Appearance: Pale yellow/Solid
• Density: 1.13g/cm³
• Vapor Pressure: 0.000513mmHg at 25°C
• Refractive Index: 1.548
• Storage Temp.: Room temperature.
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Water Solubility: soluble
• CAS DataBase Reference: 6,7-Dimethoxy-3,4-dihydroisoquinoline hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-Dimethoxy-3,4-dihydroisoquinoline hydrochloride(20232-39-7)
• EPA Substance Registry System: 6,7-Dimethoxy-3,4-dihydroisoquinoline hydrochloride(20232-39-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 24/25
• RTECS: NW7625000
• Hazardous Substances Data: 20232-39-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6,7-Dimethoxy-3,4-dihydroisoquinoline hydrochloride is used as a key intermediate in the synthesis of Tetrabenazine (T284000), a drug used for the treatment of chorea associated with Huntington's disease and other similar conditions. Its role in the synthesis process is crucial for the production of this medication, highlighting its importance in the pharmaceutical sector.

InChI:InChI=1/C11H13NO2/c1-13-10-5-8-3-4-12-7-9(8)6-11(10)14-2/h5-7H,3-4H2,1-2H3

Upstream product

• 64-18-6 formic acid 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 14301-36-1 N-[2-(3,4-dimethoxyphenyl)ethyl]formamide 
• 88-95-9 Phthaloyl dichloride 

Downstream Products

• 86457-14-9 (3S,11bS)-9,10-Dimethoxy-3-phenyl-1,3,4,6,7,11b-hexahydro-pyrido[2,1-a]isoquinolin-2-one 
• 841-95-2 9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-benzo[a]quinolizin-2-one 
• 94882-60-7 N-(2-formyl-4,5-dimethoxyphenetyl)crotonamide 
• 94882-61-8 (E)-N-[2-(2-Formyl-4,5-dimethoxy-phenyl)-ethyl]-3-phenyl-acrylamide 
• 94882-59-4 N-(2-formyl-4,5-dimethoxyphenethyl)acrylamide 
• 23359-42-4 N-(2-formyl-4,5-dimethoxyphenethyl)benzamide 
• 203806-36-4 N-[2-(2-formyl-4,5-dimethoxy-phenyl)-ethyl]-acetamide 
• 132557-22-3 (1S,2R,3R,10bS)-8,9-Dimethoxy-1-nitro-2-(3,4,5-trimethoxy-phenyl)-1,2,3,5,6,10b-hexahydro-pyrrolo[2,1-a]isoquinoline-3-carboxylic acid methyl ester 

Relevant articles and documents

DEHYDROHELIAMINE, A TRACE ALKALOID FROM THE SAGUARO, CARNEGIEA GIGANTEA (CACTACEAE)

Extraction of Carnegiea gigantea yielded a new 3,4-dihydroisoquinoline alkaloid, dehydroheliamine; the structure was confirmed by synthesis.Key Word Index-Cornegiea gigantea; Cactaceae; cactus alkaloids; dehydroheliamine; 3,4-dihydroisoquinolines.

Synthesis method of tetrabenazine intermediate

The invention relates to the field of organic synthesis, in particular to a synthesis method of a tetrabenazine intermediate 6, 7-dimethoxy-3, 4-dihydroisoquinoline hydrochloride. The method comprises: mixing 3, 4-dimethoxyphenylethylamine with ethyl formate, carrying out an aminolysis reaction of ester to obtain N-(3, 4-dimethoxyphenethyl) formamide, then dissolving an N-(3, 4-dimethoxyphenethyl)formamide crude product in an organic solvent, adding phthaloyl chloride, and carrying out a ring closing reaction to obtain a product 6, 7-dimethoxy-3, 4-dihydroisoquinoline hydrochloride. The invention provides the synthesis method of a tetrabenazine intermediate 6, 7-dimethoxy-3, 4-dihydroisoquinoline hydrochloride, and aims to solve the problems of high reaction cost, low yield, difficulty intreatment of byproducts and low product quality in the prior art.