215597-35-6

Basic information

• Product Name: 1-AMINO-CYCLOBUTANECARBOXYLIC ACID METHYL ESTER
• Synonyms: 1-AMINO-CYCLOBUTANECARBOXYLIC ACID METHYL ESTER;1, 1-ACCB(OME);Cyclobutanecarboxylic acid, 1-amino-, methyl ester (9CI);Cyclobutanecarboxylic acid, 1-aMino-, Methyl ester;Methyl 1-aMinocyclobutanecarboxylate
• CAS NO: 215597-35-6
• Molecular Formula: C₆H₁₁NO₂
• Molecular Weight: 129.16
• Product Categories: AMINEPRIMARY;AMINOACID;pharmacetical
• Mol File: 215597-35-6.mol

Chemical Properties

• Boiling Point: 162.311 °C at 760 mmHg
• Flash Point: 36.303 °C
• Appearance: /Solid
• Density: 1.127 g/cm³
• Vapor Pressure: 0.194mmHg at 25°C
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 7.71±0.20(Predicted)
• CAS DataBase Reference: 1-AMINO-CYCLOBUTANECARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 1-AMINO-CYCLOBUTANECARBOXYLIC ACID METHYL ESTER(215597-35-6)
• EPA Substance Registry System: 1-AMINO-CYCLOBUTANECARBOXYLIC ACID METHYL ESTER(215597-35-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 215597-35-6(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
1-AMINO-CYCLOBUTANECARBOXYLIC ACID METHYL ESTER is used as a building block in organic synthesis for the creation of various biologically active molecules. Its cyclic structure and ester functionality contribute to the synthesis of complex organic compounds with potential applications in different industries.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1-AMINO-CYCLOBUTANECARBOXYLIC ACID METHYL ESTER is utilized as a key intermediate in the development of new drugs and pharmaceuticals. Its unique properties allow for the exploration of its potential in treating various medical conditions, although further research is necessary to fully understand its therapeutic potential.
Used in Drug Development:
1-AMINO-CYCLOBUTANECARBOXYLIC ACID METHYL ESTER holds promise in the development of innovative drugs and pharmaceuticals. Its incorporation into drug molecules could potentially enhance their efficacy, selectivity, and pharmacokinetic properties, leading to improved therapeutic outcomes.
Safety Precautions:
Given the potential hazards associated with 1-AMINO-CYCLOBUTANECARBOXYLIC ACID METHYL ESTER, its use and handling should be conducted with appropriate safety measures and under the supervision of trained professionals. This ensures the safe application of the compound in research and development settings, minimizing risks to both individuals and the environment.

InChI:InChI=1/C6H11NO2.ClH/c1-9-5(8)6(7)3-2-4-6;/h2-4,7H2,1H3;1H

Upstream product

• 851662-64-1 methyl 1-azidocyclobutane-1-carboxylate 
• 67-56-1 methanol 
• 120728-10-1 1-[(tert-butoxycarbonyl)amino]cyclobutanecarboxylic acid 
• 70780-84-6 1-aminocyclobutane-1-carbonitrile 
• 22264-50-2 1-aminocyclobutane-1-carboxylic acid 
• 851662-59-4 3'-(p-tolylsulfinyl)spiro[cyclobutane-1,2'-oxirane] 

Downstream Products

• 115572-35-5 1-[(S)-2-((S)-2-Benzyloxycarbonylamino-propionylamino)-propionylamino]-cyclobutanecarboxylic acid methyl ester 
• 1224586-54-2 Methyl 1-(4-methoxy-2,6-dimethylphenylsulfonamido)cyclobutane-carboxylate 
• 180205-34-9 (1-aminocyclobutyl)methanol 
• 1260155-61-0 C₂₂H₂₆N₄O₃ 

Relevant articles and documents

UREA DERIVATIVES AS PYRUVATE KINASE ACTIVATORS

The subject matter described herein is directed to pyruvate kinase activating compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for the treatment of diseases associated with PKR and/or PKM2, such as pyruvate kinase deficiency, sickle cell disease, and beta-thalassemia.

Design and Synthesis of Fsp3-Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening

The exploration of innovative chemical space is a critical step in the early phases of drug discovery. Bis-spirocyclic frameworks occur in natural products and other biologically relevant metabolites and show attractive features, such as molecular compactness, structural complexity, and three-dimensional character. A concise approach to the synthesis of bis-spirocyclic-based compound libraries starting from readily available commercial reagents and robust chemical transformations has been developed. A number of novel bis-spirocyclic scaffold examples, as implemented in the European Lead Factory project, is presented.

Substituted Pyrimidine and Triazine Compounds

Substituted pyrimidine and triazine compounds corresponding to formula I wherein R1, R2, R3, R4a, R4b, R5a, R5b, R7, R8, R9a, R9b, R10, R11, A, a, b, s, t, V, W1, W2 and W3 have defined meanings, pharmaceutical compositions comprising such compounds, a process for preparing such compounds, and the use of such compounds and compositions to treat or inhibit pain and/or other disorders or disease states.

A synthesis of optically active α-quaternary α-amino acids and esters by assembling three components, ketones, (R)-chloromethyl p-tolyl sulfoxide, and sodium azide, via sulfinyloxiranes

Treatment of lithium α-sulfinyl carbanion of chloromethyl p-tolyl sulfoxides with ketones at low temperature afforded adducts in almost quantitative yields, which were exposed to t-BuOK to give sulfinyloxiranes in high yields. The sulfinyloxirane was reac

A novel synthesis, including asymmetric synthesis, of α-quaternary α-amino acid methyl esters from ketones via sulfinyloxiranes

Sulfinyloxiranes were synthesized from ketones and chloromethyl p-tolyl sulfoxide in two steps in almost quantitative yields. The sulfinyloxiranes were treated with NaN3 in the presence of NH4Cl to afford α-azido aldehydes, which wer

Enzymatic resolution of 1-amino-2-vinylcyclopropyl caboxylic acid methyl ester

An enantiomeric-resolving process for obtaining (1R,2S)-1-amino-2-vinylcyclopropyl carboxylic acid methyl ester by use of an esterase, and especially Alcalase?, is disclosed.