2177-62-0

Basic information

• Product Name: 4-Methyl hydrogen L-aspartate
• Synonyms: H-ASP(OME)-OH;L-ASPARTIC ACID BETA-METHYL ESTER;L-ASPARTIC-BETA-METHYL ESTER;Aspartic acid 4-methyl ester;(2s)-2-amino-4-methoxy-4-oxobutanoic acid;4-methyl hydrogen l-aspartate;L-Aspartic Acid-Methyl Ester;L-ASPARTIC ACID-4-METHYLESTER
• CAS NO: 2177-62-0
• Molecular Formula: C₅H₉NO₄
• Molecular Weight: 148.14
• EINECS: 218-540-2
• Product Categories: Amino Acids Derivatives
• Mol File: 2177-62-0.mol
• Article Data: 11

Chemical Properties

• Melting Point: 193-195 °C
• Boiling Point: 301.7 °C at 760 mmHg
• Flash Point: 136.3 °C
• Appearance: /
• Density: 1.299 g/cm₃
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 2.16±0.23(Predicted)
• CAS DataBase Reference: 4-Methyl hydrogen L-aspartate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methyl hydrogen L-aspartate(2177-62-0)
• EPA Substance Registry System: 4-Methyl hydrogen L-aspartate(2177-62-0)

Safety Data

• Hazardous Substances Data: 2177-62-0(Hazardous Substances Data)

Usage

Uses

β-Methyl Aspartate is a useful chemical reagent for the preparation of other amino acid derivatives. It is also reported to be fully compatible with enzymic tRNA acylation and subsequent ribosomal synthesis of modified peptides.

InChI:InChI=1/C5H9NO4/c1-10-4(7)2-3(6)5(8)9/h3H,2,6H2,1H3,(H,8,9)/t3-/m0/s1

Upstream product

• 67-56-1 methanol 
• 56-84-8 L-Aspartic acid 
• 6384-18-5 L-Aspartic acid dimethyl ester 
• 16856-13-6 (+)-β-methyl-L-aspartate hydrochloride 
• 3160-47-2 N-(benzyloxycarbonyl)-L-aspartic acid 4-methyl ester 

Downstream Products

• 137428-31-0 (S)-N,N-dibenzylaspartic acid β-methyl ester 
• 439803-74-4 2-(4-methylbenzoylamino)butane-1,4-dioic acid 4-methyl ester 
• 496060-65-2 3-acetyl-3-(4-methylbenzoylamino)propanoic acid methyl ester 
• 714568-86-2 dimethyl (2-nitrophenyl)-L-aspartate 
• 1562416-43-6 C₁₃H₁₅NO₅ 
• 86555-45-5 (2S)-N-benzoyl-L-aspartic acid dimethyl ester 
• 60272-64-2 2-phenyl-4-methoxycarbonylmethyl-5-oxo-4,5-dihydro-1,3-oxazole 
• 39741-26-9 N-benzoyl-L-aspartic acid β-methyl ester 
• 1356003-54-7 (5S)-2-(benzylsulfanyl)-1-tert-butoxycarbonyl-5-(methoxycarbonylmethyl)-4,5-dihydro-1H-imidazol-4-one 
• 1355450-27-9 methyl (2-cyclohexylidenemethyl-5-methyloxazol-4-yl)acetate 
• 1355450-26-8 methyl {2-[(E)-2-cyclohexylvinyl]-5-methyloxazol-4-yl}acetate 
• 6384-18-5 L-Aspartic acid dimethyl ester 

Relevant articles and documents

Multigram-scale and column chromatography-free synthesis of L-azetidine-2-carboxylic acid for the synthesis of nicotianamine and its derivatives

Multigram-scale synthesis of L-azetidine-2-carboxylic acid from L-aspartic acid was achieved in 13 conventional synthetic steps, without the need for purification by silica-gel column chromatography and expensive reagents. Nicotianamine and its fluorescence-labeled derivatives could be obtained from this synthetic strategy.

A PREPARATION METHOD OF SITAGLIPTIN

The present invention relates to a preparation method of sitagliptin, and more particularly, to a method of preparing sitagliptin using L-aspartic acid having a (R)-beta amino acid structure by mild amide formation, by the use of industrially applicable halo isopropylmagnesium, and by removal of amine protecting group using Pd/C and H2 and carbonyl reduction using reducing agent.