2177-63-1

Basic information

• Product Name: L-Aspartic acid 4-benzyl ester
• Synonyms: H-ASP(OBZL)-OH;H-L-ASP(OBZL)-OH;L-ASPARTIC ACID 4-BENZYL ESTER;L-ASPARTIC ACID BETA-BENZYL ESTER;ASPARTIC ACID(OBZL)-OH;BETA-BENZYL L-ASPARTATE;4-BENZYL L-ASPARTATE;benzyl hydrogen beta-L-aspartate
• CAS NO: 2177-63-1
• Molecular Formula: C₁₁H₁₃NO₄
• Molecular Weight: 223.23
• EINECS: 218-541-8
• Product Categories: Amino Acids Derivatives;AMINOACIDS DERIVATIVES;Amino Acids;Aspartic acid [Asp, D];Amino Acids and Derivatives;alpha-Amino Acids;Amino Acid Benzyl Esters;Amino Acids (C-Protected);Biochemistry
• Mol File: 2177-63-1.mol

Chemical Properties

• Melting Point: ~225 °C (dec.)
• Boiling Point: 413.1 °C at 760 mmHg
• Flash Point: 203.6 °C
• Appearance: White/Powder
• Density: 1.283 g/cm³
• Vapor Pressure: 8.17E-07mmHg at 25°C
• Refractive Index: 27 ° (C=1, 1mol/L HCl)
• Storage Temp.: −20°C
• PKA: 2.16±0.23(Predicted)
• Water Solubility: Insoluble in water.
• BRN: 1983183
• CAS DataBase Reference: L-Aspartic acid 4-benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Aspartic acid 4-benzyl ester(2177-63-1)
• EPA Substance Registry System: L-Aspartic acid 4-benzyl ester(2177-63-1)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 2177-63-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
L-Aspartic acid 4-benzyl ester is used as a synthetic intermediate for the development of various pharmaceutical compounds, particularly those with a 1,4-diazepine-2,5-dione ring structure. These compounds have potential applications in the treatment of various medical conditions due to their unique chemical properties and interactions with biological targets.
Used in Polymer Industry:
L-Aspartic acid 4-benzyl ester is also used as a monomer in the development of block copolymers. These copolymers can be utilized in various applications, such as drug delivery systems, where their unique properties can enhance the performance and functionality of the final product. The incorporation of L-aspartic acid 4-benzyl ester into block copolymers can provide specific advantages, such as improved biocompatibility, controlled release of drugs, and enhanced stability.

InChI:InChI=1/C11H13NO4/c12-9(6-10(13)14)11(15)16-7-8-4-2-1-3-5-8/h1-5,9H,6-7,12H2,(H,13,14)/t9-/m0/s1

Upstream product

• 3479-47-8 Z-Asp(OBzl)-OH 
• 56-84-8 L-Aspartic acid 
• 100-51-6 benzyl alcohol 
• 2791-79-9 dibenzyl L-aspartate 
• 2886-33-1 dibenzyl L-aspartate toluene-4-sulphonate 
• 100-39-0 benzyl bromide 
• 4427-49-0 Z(OMe)-Asp-(OBzl)-OH 
• 7536-58-5 BOC-L-aspartic acid 4-benzyl ester 
• 104-15-4 toluene-4-sulfonic acid 
• 51186-58-4 4-benzyl Boc-D-aspartate 
• 1783-96-6 (2R)-aspartic acid 
• 54759-56-7 N-phenacetyl L-aspartic acid β-benzyl ester 

Downstream Products

• 13590-42-6 N-carboxy-L-aspartic anhydride benzyl ester 
• 5513-72-4 4-benzyl hydrogen N-formyl-L-aspartate 
• 94347-11-2 4-benzyl 1-t-butyl L-aspartate 
• 7536-58-5 BOC-L-aspartic acid 4-benzyl ester 
• 4427-49-0 Z(OMe)-Asp-(OBzl)-OH 
• 13155-40-3 N-<2-Nitro-phenylsulfenyl>-L-asparaginsaeure-β-benzyl-ester 
• 3479-47-8 Z-Asp(OBzl)-OH 
• 118174-62-2 N-(Diisopropyloxyphosphoryl)-L-Asp(OBzl)-OH 
• 73535-28-1 Z-Gln-Asp(OBzl)-OH 
• 125709-80-0 (S)-3-Benzyloxycarbonyl-2-(trifluoracetylamino)propansaeure 
• 174276-38-1 Z(OMe)-Gly-Asp(OBzl)-OH 
• 129943-32-4 (S)-2-((E)-3-Pyridin-3-yl-allyloxycarbonylamino)-succinic acid 4-benzyl ester 
• 79141-08-5 Boc-valyl-β-benzylaspartic acid 
• 87016-27-1 N^α-(butyloxycarbonyl)-L-leucyl-L-aspartic acid β-benzyl ester 

Relevant articles and documents

DIPEPTIDE MIMETICS OF NGF AND BDNF NEUROTROPHINS

The invention relates to compounds having either agonist or antagonist activities for the neurotrophins NGF and BDNF and represented by monomeric or dimeric substituted dipeptides that are analogs of the exposed portions of loop 1 or loop 4 regions of these neurotrophins near or at a beta-turn of the respective loop. N-acylated substituents of these dipeptides are biostereoisomers of the amino acid residues preceding these dipeptide sequences in the neurotrophin primary structure. The dimeric structure is produced advantageously by using hexatnethylenediaanine to which dipeptides are attached via their carboxyl groups. The claimed compounds displayed neuroprotective and differentiation-inducing activities in cellular models and enhanced the amount of phosphorylated tyrosine kinase A and the heat shock proteins Hsp32 and Hsp70 in the concentration range of 10 -9 to 10 -5 M. They also displayed neuroprotective, anti-parkinsonian, anti-stroke, anti-ischemic, anti-depressant and anti-amnestic activities in animal models and were active in experimental models of Alzheimer's disease. These in vivo effects of the claimed compounds are displayed in the dose range of 0.01 to 10 mg/kg when administered intraperitoneally.

Tumor intelligent targeting and environmental double responsiveness siRNA delivery system and its preparation method and application

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Preparation method of drug-loaded nano-micelle capable of releasing anti-cancer drug in tumor matrix as well as product and application of drug-loaded nano-micelle

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Thermoresponsive Alignment Media in NMR Spectroscopy: Helix Reversal of a Copolyaspartate at Ambient Temperatures

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Photo-induced reduction of Cr6+ by the hybrid systems “CuII complex with Schiff base and TiO2”: dependence on irradiation wavelength

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N-Pyrrolidine-based α/β-peptides incorporating ABOC, a constrained bicyclic β-amino acid, for asymmetric aldol reaction catalysis

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