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ethyCyclopropanamine, 2-(3,4-difluorophenyl)-, (1R,2S)- (REACH) is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 220352-38-5 Structure
  • Basic information

    1. Product Name: ethyCyclopropanamine, 2-(3,4-difluorophenyl)-, (1R,2S)- (REACH)
    2. Synonyms: (1R,2S)-2-(3,4-Difluorophenethyl)cyclopropanamine;(1R,2S)-2-(3,4-Difluoro-phenyl)-cyclopropylamine;ethyCyclopropanamine, 2-(3,4-difluorophenyl)-, (1R,2S)- (REACH);(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine;Cyclopropanamine, 2-(3,4-difluorophenyl)-, (1R,2S)-;ethyCyclopropanaMine, 2-(3,4-difluorophenyl)-, (1R,2S)-;(1R,2S)-2-(3,4-Difluorophenyl)-cyclopropanamine mandelate
    3. CAS NO:220352-38-5
    4. Molecular Formula: C17H17F2NO3
    5. Molecular Weight: 321.3185864
    6. EINECS: 1308068-626-2
    7. Product Categories: N/A
    8. Mol File: 220352-38-5.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 212℃
    3. Flash Point: 103℃
    4. Appearance: /
    5. Density: 1.268
    6. Vapor Pressure: 0.172mmHg at 25°C
    7. Refractive Index: 1.539
    8. Storage Temp.: 2-8°C(protect from light)
    9. Solubility: N/A
    10. PKA: 8.07±0.70(Predicted)
    11. CAS DataBase Reference: ethyCyclopropanamine, 2-(3,4-difluorophenyl)-, (1R,2S)- (REACH)(CAS DataBase Reference)
    12. NIST Chemistry Reference: ethyCyclopropanamine, 2-(3,4-difluorophenyl)-, (1R,2S)- (REACH)(220352-38-5)
    13. EPA Substance Registry System: ethyCyclopropanamine, 2-(3,4-difluorophenyl)-, (1R,2S)- (REACH)(220352-38-5)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 220352-38-5(Hazardous Substances Data)

220352-38-5 Usage

Uses

(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine is a useful building block

Check Digit Verification of cas no

The CAS Registry Mumber 220352-38-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,0,3,5 and 2 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 220352-38:
(8*2)+(7*2)+(6*0)+(5*3)+(4*5)+(3*2)+(2*3)+(1*8)=85
85 % 10 = 5
So 220352-38-5 is a valid CAS Registry Number.
InChI:InChI=1/C9H9F2N/c10-7-2-1-5(3-8(7)11)6-4-9(6)12/h1-3,6,9H,4,12H2/t6-,9+/m0/s1

220352-38-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (1R,2S)-2-(3,4-difluorophenyl)cyclopropan-1-amine

1.2 Other means of identification

Product number -
Other names CYC027

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:220352-38-5 SDS

220352-38-5Relevant articles and documents

Preparation method of phenyl-containing compound

-

, (2022/01/04)

The present invention discloses a method for preparing an phenyl-containing compound. The present invention provides a method for preparing a compound shown in formula I, comprising the following steps: in the presence of formamide or acetamide, in the pr

Preparation method of chiral aromatic cyclopropylamine and salt thereof and intermediate used in preparation method

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, (2020/06/20)

The embodiment of the invention provides a preparation method of a compound as shown in a formula I or salt thereof, which comprises the following steps: (1) reacting a compound as shown in a formulaVI with a compound as shown in a formula VII in a first

Preparation method of ticagrelor chiral intermediate

-

Paragraph 0031; 0052;0053, (2019/04/06)

The invention discloses a preparation method of a ticagrelor chiral intermediate. The ticagrelor chiral intermediate is trans-(1R, 2S)-2-(3, 4-difluorophenyl) cyclopropylamine. The method includes thesteps: taking cyclopropylamine as a raw material; perfo

Synthetic method for ticagrelor intermediate (1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine

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, (2018/07/30)

The invention discloses a synthetic method for a ticagrelor intermediate (1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine. The method comprises the following steps: (5H)-furan-2-one is taken as a starting raw material, the (5H)-furan-2-one and a 3,4-difluor

(1 R, 2 S) - 2 - (3, 4 - difluorophenyl) amine ·D - mandelic acid salt preparation method

-

, (2018/02/04)

The invention discloses a preparation method of (1R,2S)-2-(3,4-difluorophenyl) rolicyprine.D-mandelate. The preparation method comprises the following steps: carrying out cyclopropanation on a compound shown in a formula V to obtain a compound shown in a formula IV; carrying out amide generation and Hofmann degradation to obtain a compound shown in a formula II; and performing salification with D-mandelic acid to obtain a compound shown in a formula I. The compound shown in the formula V is prepared in a way that a compound shown in a structure formula VI is subjected to CBS asymmetric reduction reaction, wherein a catalyst for the CBS asymmetric reduction reaction is a compound shown in a structural formula VII, and a reduction agent for the CBS asymmetric reduction reaction can be borane-tetrahydrofuran or borane-N,N-diethyl phenylamine.

A process for preparing (1 R, 2 S) - 2 - (3, 4 - difluorophenyl) amine method

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, (2018/01/11)

The invention relates to a method for preparation of (1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine represented by the formula I. The method adopts 1-(3,4-difluorophenyl)ethylene as a raw material, a dextro-laevo isomer of the formula I is obtained succes

Method for synthesizing (1R,2S)-1-amino-(3,4-difluorophenyl)-cyclopropane

-

, (2017/08/28)

The present invention relates to a method for synthesizing (1R,2S)-1-amino-(3,4-difluorophenyl)-cyclopropane. The method is characterized by comprising: 1) mixing 3,4-difluorobenzaldehyde and bis(pinacolato)diboron in tetrahydrofuran to obtain a mixture A

Synthetic method of ticagrelor midbody

-

Paragraph 0017; 0018, (2017/10/13)

The invention provides a novel synthetic method of a ticagrelor midbody (1). The synthetic method comprises the following steps: enabling a compound (2) and a compound (3) to have asymmetric tertiary cyclization reaction under the catalysis of rhodium (a

for standard auspicious Luo river intermediate preparation method

-

, (2017/08/25)

The inventiondiscloses a preparation method of ticagrelor. The method comprises the following steps: (1) reducing a compound shown in a formula III in the presence of a proton source provided by sodium borohydride or potassium borohydride and diethyl aniline hydrochloride to obtain a compound shown in a formula IV; (2) reacting the compound IV in the presence of alkali to generate a compound VI; (3) hydrolyzing the compound VI without purification to generate a compound VII; (4) reacting the compound VII to generate acyl chloride, reacting the acyl chloride to generate formamide, thus obtaining a compound shown in a formula IX; and (5) carrying out Hofmann rearrangement on the compound IX to obtain a compound shown in a formula II. Regents used in the method are nontoxic, harmless, environmentally friendly and low in price; the used key reagents can be recycled. Therefore, the method is applicable to industrial production.

Intermediate for standard auspicious Luo river (1R, 2S) - 2 - (2,3-difluorophenyl) method for the preparation of cyclopropylamines (by machine translation)

-

, (2017/03/23)

The invention discloses a method for preparing ticagrelor midbody (1R,2S)-2-(2,3-difluorophenyl) cyclopropylamine, belonging to the technical fields of organic synthesis route design and preparation of raw material medicines and midbodies. The method comprises the following steps: performing alcoholysis on succinic anhydride, thereby obtaining mono-methyl succinate, performing acylating chlorination reaction on mono-methyl succinate, thereby obtaining a compound methyl 4-chloro-4-oxobutyrate, performing Fridel-Crafts reaction on methyl 4-chloro-4-oxobutyrate and o-difluorobenzene, thereby obtaining a compound methyl 4-ketone-4-(3,4-difluorophenyl) butyrate (IV), and further performing asymmetric reduction reaction, cyclization reaction and Hoffman degradation on the compound IV, thereby obtaining the compound (1R,2S)-2-(2,3-difluorophenyl) cyclopropylamine. Initial raw materials used in the method are low in cost and easy to obtain, the reaction condition is gentle, the operation is safe, simple and convenient, the environment pollution is small, and the key ticagrelor midbody prepared by using the method is simple and convenient in after treatment, and is beneficial to on-scale production.

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