22083-21-2

Basic information

• Product Name: PHENYL-PYRROLIDIN-1-YL-ACETIC ACID ETHYL ESTER
• Synonyms: PHENYL-PYRROLIDIN-1-YL-ACETIC ACID ETHYL ESTER;Ethyl 2-phenyl-2-(pyrrolidin-1-yl)acetate
• CAS NO: 22083-21-2
• Molecular Formula: C₁₄H₁₉NO₂
• Molecular Weight: 0
• Mol File: 22083-21-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: PHENYL-PYRROLIDIN-1-YL-ACETIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: PHENYL-PYRROLIDIN-1-YL-ACETIC ACID ETHYL ESTER(22083-21-2)
• EPA Substance Registry System: PHENYL-PYRROLIDIN-1-YL-ACETIC ACID ETHYL ESTER(22083-21-2)

Safety Data

• Hazardous Substances Data: 22083-21-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
PHENYL-PYRROLIDIN-1-YL-ACETIC ACID ETHYL ESTER is used as a chemical intermediate for the synthesis of various drugs, particularly analgesics and anti-inflammatory medications. Its role in drug production is crucial due to its ability to be incorporated into the molecular structures of these medications, enhancing their therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical sector, PHENYL-PYRROLIDIN-1-YL-ACETIC ACID ETHYL ESTER serves as an intermediate in the production of various agrochemicals. Its application in this industry is essential for the development of effective compounds used in crop protection and other agricultural applications, contributing to increased crop yields and protection against pests and diseases.

Upstream product

• 122826-02-2 Benzotriazol-1-yl-pyrrolidin-1-yl-acetic acid ethyl ester 
• 123-75-1 pyrrolidine 
• 924-44-7 glyoxylic acid ethyl ester 
• 98-80-6 phenylboronic acid 
• 2882-19-1 ethyl 2-phenyl-2-bromoacetate 
• 86517-04-6 4-chlorobutylmagnesium bromide 
• 1603-79-8 phenylglyoxylic acid ethyl ester 
• 101-97-3 Ethyl 2-phenylethanoate 

Downstream Products

• 20245-72-1 2-phenyl-2-pyrrolidin-1-yl-ethanol 
• 100390-49-6 2-phenyl-2-(pyrrolidin-1-yl)acetic acid hydrochloride 
• 1446308-02-6 (3R)-1-(2-oxo-2-phenylethyl)-3-(2-phenyl-2-(pyrrolidin-1-yl)acetoxy)-1-azoniabicyclo[2.2.2]octane chloride 
• 1446308-01-5 (R)-quinuclidin-3-yl 2-phenyl-2-(pyrrolidin-1-yl)acetate 

Relevant articles and documents

Electrochemical Oxidative Coupling between Benzylic C(sp3)-H and N-H of Secondary Amines: Rapid Synthesis of α-Amino α-Aryl Esters

An intermolecular electrochemical coupling between the benzylic C(sp3)-H bond and various secondary amines is reported. The electronic behavior of two electronically rich units viz the α-position of α-aryl acetates and amines was engineered electrochemically, thus facilitating their reactivity for the direct access of α-amino esters. A series of acyclic/cyclic secondary amines and α-aryl acetates were tested to furnish the corresponding α-amino esters with high yields (up to 92%) under mild conditions.

Tandem N, N-Dialkylation Reaction of N-Trimethylsilyl α-Iminoesters Utilizing an Umpolung Reaction and Characteristics of the Silyl Substituent: Synthesis of Pyrrolidine, Piperidine, and Iminodiacetate

Umpolung reactions of N-trimethylsilyl α-iminoester with organometallics gave directly N-alkylaminoesters in high yields without the need for removing a protecting group at the nitrogen atom. Efficient syntheses of pyrrolidines, piperidines, and iminodiacetate derivatives were also developed via tandem N,N- or N,C-dialkylation reactions utilizing characteristics of the silyl substituent. Furthermore, under the influence of silica gel, the addition of an enolate to the imino nitrogen proceeded to give an iminodiacetate derivative.

Copper activation of boronic acids: Factors affecting reactivity

The generation of nucleophiles from the combination of aryl boronic acids and catalytic amounts of copper salt allows a reactivity distinct from other organometallic species, such as organolithiums or Grignard reagents. Here we examine how the electronic

QUINUCLIDINE ESTERS OF 1-AZAHETEROCYCLYLACETIC ACID AS ANTIMUSCARINIC AGENTS, PROCESS FOR THEIR PREPARATION AND MEDICINAL COMPOSITIONS THEREOF

The invention relates to compounds of formula (I), wherein A, R1, R2, X, m and n are as defined in the specification, as selective M3 receptor antagonists, process for their preparation, composition comprising them and the therapeutic use thereof. Said co

QUINUCLIDINE ESTERS OF 1-AZAHETEROCYCLYLACETIC ACID AS ANTIMUSCARINIC AGENTS, PROCESS FOR THEIR PREPARATION AND MEDICINAL COMPOSITIONS THEREOF

Compounds of formula (I): wherein A, R1, R2, X, m, and n are as defined in the specification, are selective M3 receptor antagonists and may be used in the treatment of, inter alia, a respiratory disease such as asthma and COPD.

A copper-catalyzed petasis reaction for the synthesis of tertiary amines and amino esters

We have developed a copper-catalyzed process for the coupling of aldehydes, amines, and boronic acids. This allows greater reactivity with simple aryl boronic acids and allows coupling reactions to proceed that previously failed. Initial mechanistic studi

The Chemistry of N-Substituted Benzotriazoles Part 23. Synthesis of Tertiary α-Amino Esters

2-Dialkylaminoalkanoic esters 6 are prepared in good yield by the reaction of organozinc derivatives 5 with dialkylamino(1-benzotriazolyl)acetic esters 4, obtained from the condensation of secondary amines 3 with ethyl glyoxylate 2 and benzotriazole 1.