Welcome to LookChem.com Sign In|Join Free

Cas Database

23190-16-1

23190-16-1

Identification

  • Product Name:(1R,2S)-2-Amino-1,2-diphenylethanol

  • CAS Number: 23190-16-1

  • EINECS:

  • Molecular Weight:213.279

  • Molecular Formula: C14H15NO

  • HS Code:29221990

  • Mol File:23190-16-1.mol

Synonyms:(1R,2S)-(-)-2-Amino-1,2-diphenylethanol;(1R,2S)-2-Amino-1,2-diphenyl-ethanol;(1R, 2S)-(-)-2-Amino-1,2-Diphenylethanol;

Post Buying Request Now
Entrust LookChem procurement to find high-quality suppliers faster

Safety information and MSDS view more

  • Pictogram(s):IrritantXi

  • Hazard Codes:Xi

  • Signal Word:Warning

  • Hazard Statement:H315 Causes skin irritationH319 Causes serious eye irritation H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:(1R,2S)-(-)-2-Amino-1,2-diphenylethanol
  • Packaging:25g
  • Price:$ 625
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TRC
  • Product Description:(1R,2S)-(-)-2-Amino-1,2-diphenylethanol
  • Packaging:1g
  • Price:$ 50
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TCI Chemical
  • Product Description:(1R,2S)-(-)-2-Amino-1,2-diphenylethanol >99.0%(GC)(T)
  • Packaging:1g
  • Price:$ 19
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TCI Chemical
  • Product Description:(1R,2S)-(-)-2-Amino-1,2-diphenylethanol >99.0%(GC)(T)
  • Packaging:5g
  • Price:$ 53
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:(1R,2S)-2-Amino-1,2-diphenylethan-1-ol
  • Packaging:1 g
  • Price:$ 55
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:(1R,2S)-2-Amino-1,2-diphenylethan-1-ol
  • Packaging:250 mg
  • Price:$ 25
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:(1R,2S)-2-Amino-1,2-diphenylethan-1-ol
  • Packaging:5 g
  • Price:$ 95
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Strem Chemicals
  • Product Description:(1R,2S)-2-Amino-1,2-diphenylethanol, min. 98%
  • Packaging:25g
  • Price:$ 398
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Strem Chemicals
  • Product Description:(1R,2S)-2-Amino-1,2-diphenylethanol, min. 98%
  • Packaging:5g
  • Price:$ 100
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:(1R,2S)-(?)-2-Amino-1,2-diphenylethanol 99%
  • Packaging:5g
  • Price:$ 93.8
  • Delivery:In stock
  • Buy Now

Relevant articles and documentsAll total 56 Articles be found

Double Asymmetric Hydrogenation of α-Iminoketones: Facile Synthesis of Enantiopure Vicinal Amino Alcohols

Lin, Xin,Shao, Pan-Lin,Song, Jingyuan,Wang, Jiang,Wen, Jialin,Zhang, Xumu

, p. 12729 - 12735 (2021/10/29)

This study presents an Rh/DuanPhos-catalyzed double asymmetric hydrogenation of α-iminoketones for accessing chiral vicinal amino alcohols, which are privileged motifs in pharmaceuticals, agrochemicals, fine chemicals, chiral auxiliaries, organocatalysts, etc. Compared with existing methods, this methodology has the following advantages, such as one-pot operation, high efficiency, operational simplicity, limited waste, broad reaction scope, and high yields (90 to 96%) and stereoselectivities (up to >99:1 dr; >99.9% ee). In addition, the mechanism of the transformation was revealed to be a stepwise reaction by isolating and analyzing reaction intermediates.

Site-Specific C(sp3)–H Aminations of Imidates and Amidines Enabled by Covalently Tethered Distonic Radical Anions

Fang, Yuanding,Fu, Kang,Shi, Lei,Zhao, Rong,Zhou, Jia

, p. 20682 - 20690 (2020/09/07)

The utilization of N-centered radicals to synthesize nitrogen-containing compounds has attracted considerable attention recently, due to their powerful reactivities and the concomitant construction of C?N bonds. However, the generation and control of N-centered radicals remain particularly challenging. We report a tethering strategy using SOMO-HOMO-converted distonic radical anions for the site-specific aminations of imidates and amidines with aid of the non-covalent interaction. This reaction features a remarkably broad substrate scope and also enables the late-stage functionalization of bioactive molecules. Furthermore, the reaction mechanism is thoroughly investigated through kinetic studies, Raman spectroscopy, electron paramagnetic resonance spectroscopy, and density functional theory calculations, revealing that the aminations likely involve direct homolytic cleavage of N?H bonds and subsequently controllable 1,5 or 1,6 hydrogen atom transfer.

NOVEL METHOD FOR PREPARING (2R)-2-(2-METHOXYPHENYL)-2-(OXANE-4-YLOXY)ETHANE-1-OL COMPOUND, AND INTERMEDIATE USED THEREIN

-

Paragraph 0097-0101, (2020/09/22)

A novel method for preparing a compound of Chemical Formula 1 is disclosed. The method includes a step of obtaining a compound of Chemical Formula 1 by performing a reduction reaction on a compound of Chemical Formula 2; and an intermediate used therein. According to the preparation method of the present invention, the compound of Chemical Formula 1, which is useful for the production of an acetyl-CoA carboxylase (ACC) inhibitor, can be mass-produced more simply and efficiently than that of a conventional method:

Stereoinversion of Unactivated Alcohols by Tethered Sulfonamides

Marcyk, Paul T.,Jefferies, Latisha R.,AbuSalim, Deyaa I.,Pink, Maren,Baik, Mu-Hyun,Cook, Silas P.

, p. 1727 - 1731 (2019/01/21)

The direct, catalytic substitution of unactivated alcohols remains an undeveloped area of organic synthesis. Moreover, catalytic activation of this difficult electrophile with predictable stereo-outcomes presents an even more formidable challenge. Described herein is a simple iron-based catalyst system which provides the mild, direct conversion of secondary and tertiary alcohols to sulfonamides. Starting from enantioenriched alcohols, the intramolecular variant proceeds with stereoinversion to produce enantioenriched 2- and 2,2-subsituted pyrrolidines and indolines, without prior derivatization of the alcohol or solvolytic conditions.

Large-scale preparation of key building blocks for the manufacture of fully synthetic macrolide antibiotics

Hogan, Philip C.,Chen, Chi-Li,Mulvihill, Kristen M.,Lawrence, Jonathan F.,Moorhead, Eric,Rickmeier, Jens,Myers, Andrew G.

, p. 318 - 325 (2018/03/21)

Key building blocks for the production of fully synthetic macrolides have been scaled-up in first time pilot plant and kilo-lab campaigns. These building blocks have supported the discovery of new macrolide antibiotics as well as ongoing preclinical studies.

Process route upstream and downstream products

Process route

(S)-2-phenylglycine
2935-35-5

(S)-2-phenylglycine

(+/-)-α-phenylglycine hydrochloride
71849-99-5

(+/-)-α-phenylglycine hydrochloride

Conditions
Conditions Yield
Conditions
Conditions Yield
2-amino-1,2-diphenylethanol; With L-glutamic acid; In ethanol; at 72 ℃;
In water; at 90 ℃;
72%
With L-Pyroglutamic acid; In water; at 20 ℃;
(1R,2S)-2-azido-1,2-diphenylethan-1-ol
133522-22-2

(1R,2S)-2-azido-1,2-diphenylethan-1-ol

(1R,2S)-2-Amino-1,2-diphenylethanol
23190-16-1

(1R,2S)-2-Amino-1,2-diphenylethanol

Conditions
Conditions Yield
With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 12h; atmospheric pressure;
95%
With lithium aluminium tetrahydride; In tetrahydrofuran; Yield given; Heating;
With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; for 40h; Ambient temperature;
172.3 g
C<sub>14</sub>H<sub>15</sub>NO*C<sub>14</sub>H<sub>18</sub>O<sub>5</sub>

C14H15NO*C14H18O5

(1R,2S)-2-Amino-1,2-diphenylethanol
23190-16-1

(1R,2S)-2-Amino-1,2-diphenylethanol

(R)-2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)acetic acid

(R)-2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)acetic acid

Conditions
Conditions Yield
With hydrogenchloride; water; In dichloromethane; pH=1 - 2;
84%
94%
(1R,2S)-1,2-diphenyl-2-(4-methoxy-anilino)-ethan-1-ol

(1R,2S)-1,2-diphenyl-2-(4-methoxy-anilino)-ethan-1-ol

(1R,2S)-2-Amino-1,2-diphenylethanol
23190-16-1

(1R,2S)-2-Amino-1,2-diphenylethanol

Conditions
Conditions Yield
With ammonium cerium (IV) nitrate; In methanol; water;
85%
Conditions
Conditions Yield
With sodium amalgam; ethanol; acetic acid;
With hydrogen; palladium on activated charcoal; In tetrahydrofuran; under 2206.52 Torr;
N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]formamide
301191-47-9

N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]formamide

(1R,2S)-2-Amino-1,2-diphenylethanol
23190-16-1

(1R,2S)-2-Amino-1,2-diphenylethanol

Conditions
Conditions Yield
N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]formamide; With thionyl chloride; at -15 - 20 ℃;
With water; for 3h; Heating;
88%
(1S)-2-benzyloxyimino-1,2-diphenylethane-1-ol

(1S)-2-benzyloxyimino-1,2-diphenylethane-1-ol

(1S,2R)-2-Amino-1,2-diphenylethanol
23364-44-5

(1S,2R)-2-Amino-1,2-diphenylethanol

(1R,2S)-2-Amino-1,2-diphenylethanol
23190-16-1

(1R,2S)-2-Amino-1,2-diphenylethanol

Conditions
Conditions Yield
With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 25h; Title compound not separated from byproducts;

Global suppliers and manufacturers

Global( 144) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
  • Simagchem Corporation
  • Business Type:Manufacturers
  • Contact Tel:+86-592-2680277
  • Emails:sale@simagchem.com
  • Main Products:110
  • Country:China (Mainland)
  • Chemwill Asia Co., Ltd.
  • Business Type:Manufacturers
  • Contact Tel:021-51086038
  • Emails:sales@chemwill.com
  • Main Products:30
  • Country:China (Mainland)
  • Amadis Chemical Co., Ltd.
  • Business Type:Lab/Research institutions
  • Contact Tel:86-571-89925085
  • Emails:sales@amadischem.com
  • Main Products:29
  • Country:China (Mainland)
  • Shaanxi BLOOM TECH Co.,Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-29-86470566
  • Emails:sales@bloomtechz.com
  • Main Products:80
  • Country:China (Mainland)
  • Shanghai Upbio Tech Co.,Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-21-52196435
  • Emails:upbiocn@hotmail.com
  • Main Products:88
  • Country:China (Mainland)
close
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 23190-16-1
Post Buying Request Now
close
Remarks: The blank with*must be completed