23515-44-8Relevant articles and documents
COMPOUNDS AS MODULATORS OF GHRELIN RECEPTOR AND USES THEREOF
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Page/Page column 61, (2008/06/13)
Disclosed herein are compounds of Formula (I) as defined herein, or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, that selectively activate the ghrelin receptor, and pharmaceutical compositions comprising the same. Disclosed herein are also methods of treatment of diseases and disorders comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I).
cis-(±)-5-[2- (Dimethylamino)ethyl]-3-hydroxy-2-(4- methoxyphenyl )-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-one
Kumaradhas,Nirmala,Sridhar
, p. 2595 - 2597 (2007/10/03)
The title compound, C20H24N2O3S, is a drug intermediate of diltiazem. The molecule is stabilized by covalent bonding and weak hydrogen bonding, and the crystal packing is stabilized by hydrogen bonding. The seven-membered ring is distorted showing a twist-boat conformation. The methoxyphenyl and hydroxy groups are cis oriented with respect to one another, with the phenyl ring in an axial position. Intermolecular hydrogen bonding produces dimers in the crystal.
Naphthalene derivatives and method for preparation thereof
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, (2008/06/13)
A naphthalene derivative of the formula: STR1 wherein R1 is hydrogen and R2 is lower alkyl or phenyl-lower alkyl; or R1 and R2 are combined together to form lower alkylene; X is halogen; and the absolute configu