2454-39-9

Basic information

• Product Name: 2-AMINO-THIOBENZAMIDE
• Synonyms: 4-AMINO THIOBENZAMIDE 98.0%MIN;Thioanthranilamide;2-Aminothiobenzamide,98%;2-Aminobenzene-1-carbothioamide;2-Carbamothioylaniline, 2-Aminobenzenecarbothioamide;2-Aminobenzothioamide;2-AMINO-THIOBENZAMIDE
• CAS NO: 2454-39-9
• Molecular Formula: C₇H₈N₂S
• Molecular Weight: 152.22
• Mol File: 2454-39-9.mol
• Article Data: 13

Chemical Properties

• Melting Point: 120 °C
• Boiling Point: 318.8 °C at 760mmHg
• Flash Point: 146.6 °C
• Appearance: Light yellow to yellow crystalline powder
• Density: 1.286 g/cm³
• Vapor Pressure: 0.000353mmHg at 25°C
• Refractive Index: 1.719
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 12.51±0.29(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 2-AMINO-THIOBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-THIOBENZAMIDE(2454-39-9)
• EPA Substance Registry System: 2-AMINO-THIOBENZAMIDE(2454-39-9)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-43-36-22
• Safety Statements: 26-36/37/39-36/37
• Hazardous Substances Data: 2454-39-9(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow to yellow crystalline powder

Uses

It can be heated to produce 2-trifluoromethyl-3H-quinazoline-4-thione in the presence of reagent molecular sieves and solvent CHCl3 with reaction time of 2 hours. It is an important organic intermediate used in agrochemicals, pharmaceuticals and dyestuff fields.

InChI:InChI=1/C7H8N2S/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H2,9,10)

Upstream product

• 1885-29-6 anthranilic acid nitrile 
• 28144-70-9 anthranilic acid amide 
• 612-24-8 o-nitrobenzonitrile 
• 100698-05-3 2,3-dihydro-2-mercapto-2,1,3-benzophosphadiazine-4(1H)-thione 2-sulphide 
• 100698-06-4 2-mercapto-2-thioxo-2,3-dihydro-1H-2λ⁵-benzo[1,3,2]diazaphosphinine-4-thione pyridinium salt 
• 7783-06-4 hydrogen sulfide 
• 7664-41-7 ammonia 

Downstream Products

• 6484-28-2 2-methyl-4(3H)-quinazolinethione 
• 69729-68-6 2-ethyl-3H-quinazoline-4-thione 
• 91760-82-6 2,2-dimethyl-2,3-dihydro-1H-quinazoline-4-thione 
• 2536-88-1 3H-benzo[1,2,3]triazine-4-thione 
• 37802-50-9 [2-(2-amino-phenyl)-4-oxo-4H-thiazol-5-ylidene]-acetic acid methyl ester 
• 793716-07-1 4-imino-1,4-dihydro-benzo[d][1,3]thiazine-2-thione 
• 33759-66-9 2-oxo-2,3-dihydro-1H-2λ⁴-benzo[1,2,6]thiadiazine-4-thione 
• 100698-06-4 2-mercapto-2-thioxo-2,3-dihydro-1H-2λ⁵-benzo[1,3,2]diazaphosphinine-4-thione pyridinium salt 
• 76164-70-0 Ethyl 3-(2-Thiocarbamoylanilino)methylene-2,4-dioxovalerate 
• 124763-82-2 2-<3-(2-chloroethyl)ureido>thiobenzamide 
• 124763-83-3 2-<3-(3-Chloropropyl)ureido>thiobenzamide 
• 59525-07-4 4-methyl-N-(2-thiocarbamoyl-phenyl)-benzamide 
• 28144-70-9 anthranilic acid amide 
• 27259-73-0 2-(2-aminophenyl)-4(1H)-quinazolone 

Relevant articles and documents

Anithiactins A-C, modified 2-phenylthiazoles from a mudflat-derived streptomyces sp.

Intensive investigation of the chemical components of a Streptomyces sp. isolated from mudflat sediments collected on the southern coast of the Korean peninsula led to the isolation of three new compounds, anithiactins A-C (1-3). The chemical structures of anithiactins A and C were determined by interpretation of NMR data analyses, while the chemical structure of anithiactin B was established from a combination of NMR spectroscopic and crystallographic data analyses. The structure of anithiactin A was also confirmed by total synthesis. These three anithiactins displayed moderate acetylcholinesterase inhibitory activity with no significant cytotoxicity.

Evaluation of thioamides, thiolactams and thioureas as hydrogen sulfide (H2S)donors for lowering blood pressure

Hydrogen sulfide (H2S)is a biologically important gaseous molecule that exhibits promising protective effects against a variety of pathological processes. For example, it was recognized as a blood pressure lowering agent. Aligned with the need for easily modifiable platforms for the H2S supply, we report here the preparation and the H2S release kinetics from a series of structurally diversified thioamides, thiolactams and thioureas. Three different thionation methods based on the usage of a phosphorus pentasulfide and Lawesson reagent were applied to prepare the target thioamides and thiolactams. Furthermore, obtained H2S donors were evaluated both in in vivo and in vitro studies. The kinetic parameters of the liberating H2S was determined and compared with NaHS and GYY4137 using two different detection technics i.e.; fluorescence labeling 7-azido-4-methyl-2H-chromen-2-one and 5,5‘-dithiobis (2-nitrobenzoic acid), sulfhydryl probe, also known as the Ellman's reagent. We have proved that the amount of releasing H2S from these compounds is controllable through structural modifications. Finally, the present study shows a hypotensive response to an intravenous administration of the developed donors in the anesthetized rats.

One-Pot Synthesis of 5-Hydroxy-4H-1,3-thiazin-4-ones: Structure Revision, Synthesis, and NMR Shift Dependence of Thiasporine A

An annulation of arylthioamides with 3-bromopyruvic acid chloride to 5-hydroxy-4H-1,3-thiazin-4-ones has been developed. The initial condensation affords two regioisomeric thiazolinone intermediates in a temperature-dependent manner. The synthesis of the 2-aminophenylthiazinone derivative led to the revision of the previously proposed structure of thiasporine A. Synthesis of the revised structure and NMR analysis revealed that thiasporine A had been isolated as a carboxylate.