252881-73-5

Basic information

• Product Name: N3-PEG3-tBu
• Synonyms: N3-PEG3-tBu;N3-PEG3-CH2CH2COOtBu;3-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]propanoic acid 1,1-dimethylethyl ester;N3-PEG3-CH2CH2COOtBu;tert-butyl 3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoate
• CAS NO: 252881-73-5
• Molecular Formula: C₁₃H₂₅N₃O₅
• Molecular Weight: 303.3547
• Mol File: 252881-73-5.mol
• Article Data: 24

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N3-PEG3-tBu(CAS DataBase Reference)
• NIST Chemistry Reference: N3-PEG3-tBu(252881-73-5)
• EPA Substance Registry System: N3-PEG3-tBu(252881-73-5)

Safety Data

• Hazardous Substances Data: 252881-73-5(Hazardous Substances Data)

Usage

Description

Azido-PEG3-t-butyl ester is a click chemistry reagent. The hydrophilic PEG spacer increases solubility in aqueous media. The azide (N3) group canis reactive with alkyne, such as BCN, DBCO via Click Chemistry. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Upstream product

• 186020-66-6 3-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-propionic acid tert-butyl ester 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 1663-39-4 tert-Butyl acrylate 
• 1024602-74-1 tert-butyl 3-(2-{2-[2-(methanesulphonyloxy)ethoxy]ethoxy}ethoxy)propanoate 
• 217817-01-1 tert-butyl 3-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]propanoate 

Downstream Products

• 867062-95-1 12-{N-[(9H-fluoren-9-yl)methoxycarbonyl]amido}-4,7,10-trioxadodecanoic acid 
• 1610796-02-5 2,5-dioxopyrrolidin-1-yl 3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoate 
• 252881-74-6 tert-butyl 3-(2-(2-(2-aminoethoxyl)ethoxy)ethoxy)propanoate 
• 1814901-03-5 aminobis(4,7,10-trioxadodecanoic acid tert-butyl ester) 
• 1253286-56-4 2,5-dioxopyrrolidin-1-yl 14-oxo-18-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-4,7,10-trioxa-13-azaoctadecanoate 
• 252881-76-8 biotin-PEG₃-acid 

Relevant articles and documents

Amphiphilic Cyclodextrin-Based Liquid Crystals for Proton Conduction

Novel cyclodextrin (CD)-based amphiphilic poly(carboxylic acid)s that self-assemble into highly ordered smectic liquid crystalline mesophases were investigated as a novel class of protonic conductors. These structurally well-defined materials are synthesized from nontoxic and environment-friendly CDs, which possess a unique face-to-face pseudosymmetry. By taking advantage of such geometry, a series of flexible tetraethylene glycol groups terminated with a carboxylic acid functionality were introduced to the CD's secondary face, resulting in the formation of long-range 2D hydrogen-bond networks in the smectic mesophases over a wide temperature window. This new material was found to exhibit impressive proton conductivities in solid states, up to 1.4 × 10-2 S cm-1 at 70 °C and 95% humidity. This constitutes the first report of amphiphilic CD-based liquid crystals applied as proton conductive materials.

CROSS-LINKED PYRROLOBENZODIAZEPINE DIMER (PBD) DERIVATIVE AND ITS CONJUGATES

A novel cross-linked cytotoxic agents, pyrrolobenzo-diazepine dimer (PBD) derivatives, and their conjugates to a cell-binding molecule, a method for preparation of the conjugates and the therapeutic use of the conjugates.

A CONJUGATE OF A CYTOTOXIC AGENT TO A CELL BINDING MOLECULE WITH BRANCHED LINKERS

Provided is a conjugation of cytotoxic drug to a cell-binding molecule with a side-chain linker. It provides side-chain linkage methods of making a conjugate of a cytotoxic molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and immunological disorders.