253222-68-3

Basic information

• Product Name: polyethylene glycol
• CAS NO: 253222-68-3
• Mol File: 253222-68-3.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: polyethylene glycol(CAS DataBase Reference)
• NIST Chemistry Reference: polyethylene glycol(253222-68-3)
• EPA Substance Registry System: polyethylene glycol(253222-68-3)

Safety Data

• Hazardous Substances Data: 253222-68-3(Hazardous Substances Data)

Usage

Chemical Description

Polyethylene glycol is a polymer made from ethylene oxide and water, commonly used as a solvent, lubricant, and thickening agent.

Upstream product

• 108-30-5 succinic acid anhydride 
• 822-06-0 Hexamethylene diisocyanate 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 55750-48-6 N-methoxycarbonylmaleimide 
• 25529-27-5 Z-Lys(Z)-OPfp 
• 56-81-5 glycerol 

Relevant articles and documents

PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) TARGETED NANOPARTICLES FOR THERAPY OF PROSTATE CANCER

The invention provides a nanoparticle composition that is decorated with a urea-based small-molecule peptidomimetic inhibitor of prostate specific membrane antigen (PSMA), which is expressed by almost all solid tumors. This strategy takes advantage of both the avidity of the functionalized nanoparticle for binding to PSMA and the ability of the nanoparticle to be retained for longer periods of time in the tumor due to enhanced leakage via EPR into the tumor interstitium and poor clearance due to underdeveloped or non-existent lymphatics within the tumor.

Method for preparing polymer maleimides

Methods for preparing polymeric reagents bearing a maleimide are provided. Also provided are compositions comprising the polymeric reagents, and conjugates prepared by polymeric reagents obtained by the described methods.

Conjugates of the hydrophilic polymer and the molecules from boxwood extraction, and pharmaceutical compositions of the conjugates

The present invention relates to a group of conjugates of the hydrophilic polymers and the molecules from boxwood extraction. PEGylation process or the process alike was used to generate the conjugates, which have increased water solubility and prolonged the circulation half-life in the body.