25408-61-1

Basic information

• Product Name: N,N-DIMETHYL-2,2-DIMETHOXY ACETAMIDE
• Synonyms: 2,2-DIMETHOXY-N,N-DIMETHYL-ACETAMIDE;N,N-DIMETHYL-2,2-DIMETHOXY ACETAMIDE;N,N-Dimethyl-2,2-dimethoxy
• CAS NO: 25408-61-1
• Molecular Formula: C₆H₁₃NO₃
• Molecular Weight: 147.17
• Mol File: 25408-61-1.mol

Chemical Properties

• Boiling Point: 181.478 °C at 760 mmHg
• Flash Point: 63.556 °C
• Appearance: /
• Density: 1.015 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.59±0.70(Predicted)
• CAS DataBase Reference: N,N-DIMETHYL-2,2-DIMETHOXY ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-DIMETHYL-2,2-DIMETHOXY ACETAMIDE(25408-61-1)
• EPA Substance Registry System: N,N-DIMETHYL-2,2-DIMETHOXY ACETAMIDE(25408-61-1)

Safety Data

• Hazardous Substances Data: 25408-61-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Organic Synthesis:
N,N-DIMETHYL-2,2-DIMETHOXY ACETAMIDE is used as a solvent in pharmaceutical and organic synthesis applications for its ability to dissolve a wide range of compounds and facilitate various chemical reactions.
Used in Polymerization of Vinyl Chloride:
N,N-DIMETHYL-2,2-DIMETHOXY ACETAMIDE is used as a stabilizer and inhibitor in the polymerization of vinyl chloride to prevent unwanted side reactions and ensure the production of high-quality polymers.
Used in Metalworking Fluids:
N,N-DIMETHYL-2,2-DIMETHOXY ACETAMIDE is used as a corrosion inhibitor in metalworking fluids to protect metal surfaces from corrosion and extend the life of the equipment.

Upstream product

• 124-41-4 sodium methylate 
• 5468-76-8 2,2-dichloro-N,N-dimethylacetamide 
• 89-91-8 Methyl dimethoxyacetate 
• 124-40-3 dimethyl amine 

Downstream Products

• 266675-81-4 (E)-(3R,6S)-7-(tert-Butyl-diphenyl-silanyloxy)-3-[2-(4-methoxy-benzyloxy)-ethyl]-3,6-dimethyl-hept-4-enoic acid dimethylamide 
• 41421-03-8 5-(4-bromophenyl)-2-methyl-1,3,4-oxadiazole 
• 65370-33-4 C₁₄H₁₆N₄O₂ 
• 52415-29-9 6-bromo-1H-indole 
• 66521-54-8 3-(dimethylamino)-1-(pyridine-2-yl)prop-2-en-1-one 
• 118026-14-5 N,N,6-trimethyl-2-(4-methylphenyl)-imidazo[1,2-α]pyridine-3-α-hydroxyacetamide 

Relevant articles and documents

Preparation method of zolpidem

The invention discloses a preparation method of a zolpidem intermediate. In the process of preparing the zolpidem intermediate N, N, 6-trimethyl-2-(4-methylphenyl)-imidazo [1, 2-alpha] pyridine-3-acetamide hydrochloride by reducing N, N, 6-trimethyl-2-(4-methylphenyl)-imidazo [1, 2-alpha] pyridine-3-acetamide hydrochloride, through process optimization and parameter adjustment, by using a 10% palladium-carbon catalyst and combining the reaction condition of hydrogen pressure of 0.02-0.09 MPa, the conversion effect of the N, N, 6-trimethyl-2-(4-methylphenyl)-imidazo [1, 2-alpha] pyridine-3-chloroacetamide hydrochloride is promoted, side reactions and impurities are reduced, the product yield is increased, the problem of low product synthesis yield in the process of preparing N, N, 6-trimethyl-2-(4-methylphenyl)-imidazo [1, 2-alpha] pyridine-3-acetamide hydrochloride through reduction reaction in zolpidem production is solved, and the production cost of zolpidem tartrate is reduced.

METHOD FOR THE PRODUCTION OF ACETAMIDE ACETALS

The invention relates to a method for production of acetamide acetals of formula (I), where R1 and R2 independently = C1-C6 alkyl, phenyl or benzyl, or together form a C2-C6 alkylene and R3 and R4 independently = H, C1-C6 alkyl or benzyl, or together form a C3-C6 alkylene, whereby a glyoxylate ester diacetal of formula (II), in which R1 and R2 are as above and R5 = C1-C4 alkyl, is reacted with DMF or an amine of formula (III) NHR4R5, where R4 and R5 are as above, in the presence of 0.005 to 3 Mol %, based on the amine of formula (III), of an alcoholate of formula (IV) XOC1-C4, where X = Na, K or Li, at a reaction temperature of 0 to 100 °C to give the corresponding compound of formula (I).

Process for the preparation of imidazopyridines

A process for the preparation of an imidazopyridine which is a compound of formula (I) STR1 in which: Y denotes hydrogen, a halogen or a C1-4 alkyl group; X1 and X2 denote, independently of each other, hydrogen, a halogen or a C1-4 alkoxy, C1-6 alkyl, CF3, CH3 S, CH3 SO2 or NO2 group; and R1 and R2 denote, independently of each other, hydrogen or a C1-5 alkyl group, with the proviso that R1 and R2 do not both denote hydrogen, or a salt thereof; which process comprises reacting a compound of formula (V) STR2 wherein Y, X1, X2, R1 and R2 are as defined above, with a reducing agent and if desired converting the resulting compound of formula (I) into a salt, together with intermediates of formulae: STR3 The final products have useful pharmacological properties, e.g. as anxiolytics.