26081-03-8

Basic information

• Product Name: (R)-3-AMINOAZEPAN-2-ONE HYDROCHLORIDE
• Synonyms: (R)-3-AMINOAZEPAN-2-ONE HYDROCHLORIDE;2H-Azepin-2-one, 3-aminohexahydro-, hydrochloride (1:1), (3R)-;D-AMino caprolactaM HCL SALT;R-3-AMinohexahydro-2H-azepin-2-one hydrochloride;(3R)-3-Aminohexahydro-2H-azepin-2-one monohydrochloride;D (-)-ALPHA-AMINO-EPSILON-CAPROLACTAM HYDROCHLORIDE
• CAS NO: 26081-03-8
• Molecular Formula: C₆H₁₂N₂O*ClH
• Molecular Weight: 164.635
• Mol File: 26081-03-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO (Slightly, Sonicated), Methanol (Slightly), Water (Slightly)
• CAS DataBase Reference: (R)-3-AMINOAZEPAN-2-ONE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-AMINOAZEPAN-2-ONE HYDROCHLORIDE(26081-03-8)
• EPA Substance Registry System: (R)-3-AMINOAZEPAN-2-ONE HYDROCHLORIDE(26081-03-8)

Safety Data

• Hazardous Substances Data: 26081-03-8(Hazardous Substances Data)

Usage

Description

(R)-3-AMINOAZEPAN-2-ONE HYDROCHLORIDE, also known as (R)-JQ1, is a chemical compound that has demonstrated potential as a therapeutic agent for the treatment of various cancers and diseases. It is a potent and selective inhibitor of the BET family of bromodomain-containing proteins, which play a crucial role in the regulation of gene expression. (R)-3-AMINOAZEPAN-2-ONE HYDROCHLORIDE has been studied for its ability to inhibit the growth of cancer cells, particularly in leukemia, lymphoma, and solid tumors, as well as for its potential in treating certain inflammatory and autoimmune diseases. As a result, (R)-3-AMINOAZEPAN-2-ONE HYDROCHLORIDE has emerged as a promising candidate for the development of novel therapeutic interventions.

Uses

Used in Oncology:
(R)-3-AMINOAZEPAN-2-ONE HYDROCHLORIDE is used as an anticancer agent for its ability to inhibit the growth of cancer cells, particularly in leukemia, lymphoma, and solid tumors. It targets the BET family of bromodomain-containing proteins, which are involved in the regulation of gene expression, and disrupts the processes that contribute to cancer cell proliferation and survival.
Used in the Treatment of Inflammatory and Autoimmune Diseases:
(R)-3-AMINOAZEPAN-2-ONE HYDROCHLORIDE is used as a potential treatment for certain inflammatory and autoimmune diseases due to its ability to modulate the activity of the BET family of proteins. By targeting these proteins, it may help in controlling inflammation and immune responses associated with these conditions.
Used in Drug Development:
(R)-3-AMINOAZEPAN-2-ONE HYDROCHLORIDE is used as a promising candidate for the development of novel therapeutic interventions in various medical fields. Its potential as a therapeutic agent in the treatment of cancers and diseases has garnered interest among researchers and pharmaceutical companies, leading to further studies and exploration of its applications in medicine.

Upstream product

• 6804-88-2 α-nitrocaprolactam 
• 26081-03-8 (-)-3-aminocaprolactam hydrochloride 
• 56-87-1 L-lysine 
• 13515-95-2 lysine methyl ester dihydrochloride 
• 657-27-2 L-Lysine hydrochloride 

Downstream Products

• 26081-03-8 3-Amino-azepan-2-one; hydrochloride 
• 1352127-94-6 (S)-3-(3'-butylbenzoylamino)-azepan-2-one 
• 1352127-95-7 (S)-3-(4'-ethylbenzoylamino)-azepan-2-one 
• 1352127-97-9 (S)-3-(4'-butylbenzoylamino)-azepan-2-one 
• 1352128-06-3 (S)-3-(4'-octylbenzoylamino)-azepan-2-one 
• 1352128-00-7 (S)-3-(4'-tert-butylbenzoylamino)-azepan-2-one 
• 1352128-03-0 (S)-3-(4'-hexylbenzoylamino)-azepan-2-one 
• 1352144-05-8 (S)-3-(4'-octylbenzenesulfonylamino)-azepan-2-one 
• 1352144-01-4 (S)-3-(4'-butylbenzenesulfonylamino)-azepan-2-one 
• 1352143-99-7 (S)-3-(4'-ethylbenzenesulfonylamino)-azepan-2-one 

Relevant articles and documents

Protecting-Group-Free Amidation of Amino Acids using Lewis Acid Catalysts

Amidation of unprotected amino acids has been investigated using a variety of ‘classical“ coupling reagents, stoichiometric or catalytic group(IV) metal salts, and boron Lewis acids. The scope of the reaction was explored through the attempted synthesis of amides derived from twenty natural, and several unnatural, amino acids, as well as a wide selection of primary and secondary amines. The study also examines the synthesis of medicinally relevant compounds, and the scalability of this direct amidation approach. Finally, we provide insight into the chemoselectivity observed in these reactions.

SYNTHESIS OF CAPROLACTAM FROM LYSINE

In various embodiments, the present invention can involve a method of synthesizing α-amino-ε -caprolactam. The method can comprise heating a salt of L-lysine in a solvent comprising an alcohol. In other embodiments, the present invention can involve methods for synthesizing ε-caprolactam. The methods can comprise heating a salt of L-lysine in a solvent comprising an alcohol and deaminating the reaction product. In various embodiments, the invention can include methods of converting biomass into nylon 6. The methods can comprise heating L-lysine in a solvent comprising an alcohol to produce α-amino -ε- caprolactam, deaminating to produce ε-caprolactam and polymerizing into nylon 6, wherein the L-lysine is derived from the biomass. In other embodiments, the present invention can include methods of making nylon 6. The methods can comprise synthesizing ε-caprolactam and then polymerizing, wherein the ε--caprolactam is derived from L-lysine.

CATALYTIC ASYMMETRIC SYNTHESIS OF L-LYSINE

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