26172-55-4Relevant articles and documents
Preparation method of 2-methyl-4-isothiazoline-3-one aqueous solution
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Paragraph 0045-0047, (2020/12/31)
The invention provides a preparation method of a 2-methyl-4-isothiazoline-3-one aqueous solution. The method comprises the following concrete steps: uniformly mixing N,N'-dimethyl-3,3'-dithiodipropionamide or N-methyl-3-mercaptopropionamide with a solvent; adding a halogenating agent into the mixed solution, and carrying out a halogenation ring closing reaction; filtering to obtain a product, washing a filter cake with ethyl acetate, and drying to obtain a 2-methyl-4-isothiazoline-3-one hydrochloride solid; and dissolving the 2-methyl-4-isothiazoline-3-one hydrochloride solid by using a sodiumcarbonate aqueous solution to obtain an aqueous solution of which the pH value is 5.0-7.0 and the mass fraction of 2-methyl-4-isothiazoline-3-one is 50%. According to the invention, the purity of the2-methyl-4-isothiazoline-3-one obtained by the method reaches 99.9% or above, and the content of 5-chlorine-2-methyl-4-isothiazoline-3-one can be controlled to be 100 ppm or below.
Pipeline type continuous production method of 3-isothiazolinone compound
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Paragraph 0018, (2019/12/02)
The invention discloses a pipeline type continuous production method of a 3-isothiazolinone compound, which comprises the following steps: carrying out mixed reaction on a thioamide compound, a catalyst, a solvent and chlorine through a pipeline reactor system, and carrying out after-treatment after the reaction is completed to obtain the 3-isothiazolinone compound. According to the method, the defects of large occupied area, small productivity, low efficiency, high energy consumption and small safety coefficient caused by existing batch production of the 3-isothiazolinone compound are overcome; the invention provides a mode for continuously producing the 3-isothiazolinone compound, so that the reaction process is easy to control, energy consumption is reduced, the production efficiency and the safety coefficient of the production process are improved, and the process is an efficient and energy-saving safe production process.
MICROBICIDE
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Paragraph 0065; 0067, (2016/12/07)
5-chloro-2-methyl-4-isothiazolin-3-yn as an active ingredient together with an, used in process for manufacturing a product of the co-organic solvent, in the residue and hydrolysates content of reduced for providing immunomodulated microbicidal, and ring alcoholic beverage group id amide 3-isothiazolone with a lactam-type including halogenation anger hydrogen salt neutralizing process device in manufacturing process, ring process moisture content as reaction solvent, the amount of acetic acid, ester and 0.1 weight % hereinafter, neutralizing step before the halogen anger hydrogen salt an ester of acetic acid dispersions obtained to filter out moisture content 0.1 weight % hereinafter in anger hydrogen salt halogen said hydrocarbon is added catalyst and a stabilizing agent to provide access to the filtration for solvent of exchanging and, moisture content collect the blood and to easily solvent exchange from process ring in addition 0.1 weight % hereinafter in an atmosphere of embodiment obtained with the device, which are in 5-chloro-2-methyl-4-isothiazoline-3-on as the active ingredient and, 10% weight concentration active ingredient when organic solvents and the Singer and total content of hydrolysate is microbicidal microbicides 200 888000000088 8 hereinafter.