26211-73-4

Basic information

• Product Name: 3-BENZOYL-2-METHYLINDOLE
• Synonyms: 3-BENZOYL-2-METHYLINDOLE;3-Benzoyl-2-methyl-1H-indole
• CAS NO: 26211-73-4
• Molecular Formula: C₁₆H₁₃NO
• Molecular Weight: 235.28052
• Mol File: 26211-73-4.mol
• Article Data: 36

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-BENZOYL-2-METHYLINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BENZOYL-2-METHYLINDOLE(26211-73-4)
• EPA Substance Registry System: 3-BENZOYL-2-METHYLINDOLE(26211-73-4)

Safety Data

• Hazardous Substances Data: 26211-73-4(Hazardous Substances Data)

Upstream product

• 110-86-1 pyridine 
• 613-90-1 benzoyl cyanide 
• 95-20-5 2-methyl-1H-indole 
• 67-66-3 chloroform 
• 19798-74-4 2-Ethoxy-2-phenyl-1,3-dioxolane 
• 85239-71-0 (E)-3-(2-Bromo-phenylamino)-1-phenyl-but-2-en-1-one 
• 128942-79-0 (E)-3-(2-Iodo-phenylamino)-1-phenyl-but-2-en-1-one 
• 120-72-9 indole 
• 98-88-4 benzoyl chloride 
• 591-50-4 iodobenzene 
• 13939-06-5 molybdenum hexacarbonyl 
• 63468-90-6 phenylglyoxylic acid potassium salt 
• 98-86-2 acetophenone 
• 101-97-3 Ethyl 2-phenylethanoate 

Downstream Products

• 243-28-7 2,3-benzocarbazole 
• 59411-02-8 (1,2-dimethyl-1H-indol-3-yl)(phenyl)methanone 
• 78593-50-7 (1-ethyl-2-methyl-1H-indol-3-yl)(phenyl)methanone 
• 82595-12-8 (3-Benzoyl-2-bromomethyl-indol-1-yl)-(4-methoxy-phenyl)-methanone 
• 82595-10-6 (3-Benzoyl-2-bromomethyl-indol-1-yl)-(4-bromo-phenyl)-methanone 
• 82595-11-7 (3-Benzoyl-2-bromomethyl-indol-1-yl)-(4-chloro-phenyl)-methanone 
• 82595-31-1 (4-Methoxy-phenyl)-(1-phenyl-selenolo[3,4-b]indol-4-yl)-methanone 
• 82595-23-1 (4-Methoxy-phenyl)-(1-phenyl-thieno[3,4-b]indol-4-yl)-methanone 
• 82595-29-7 (4-Bromo-phenyl)-(1-phenyl-selenolo[3,4-b]indol-4-yl)-methanone 
• 82595-30-0 (4-Chloro-phenyl)-(1-phenyl-selenolo[3,4-b]indol-4-yl)-methanone 
• 82595-21-9 (4-Bromo-phenyl)-(1-phenyl-thieno[3,4-b]indol-4-yl)-methanone 
• 82595-22-0 (4-Chloro-phenyl)-(1-phenyl-thieno[3,4-b]indol-4-yl)-methanone 
• 82595-09-3 1,3-dibenzoyl-2-bromomethylindole 
• 82595-17-3 1-phenyl-4-benzoylthieno<3,4-b>indole 

Relevant articles and documents

3-benzoyl-2-methylindole

The crystal and molecular structure of C16H13NO has been determined. Bond lengths and angles are within normal ranges and molecules are held together in the crystal by intermolecular N-H...O hydrogen bonding.

Lithium-Promoted Cycloaddition of Indole-2,3-dienolates and Carbon Disulfide as a One-Pot Route to Thiopyrano[4,3- b]indole-3(5 H)-thiones

A new approach for the annulation of a thiopyrane ring to an indole core under mild conditions was developed. Treating 2-methyl-3-acylindoles with lithium diisopropyl amide leads to the elimination of a proton from the 2-methyl group. The lithium indole-2,3-dienolates obtained were found to react with CS2 to give the corresponding thiopyrano[4,3-b]indole-3(5H)-thiones. The mechanism represents a stepwise addition through ion-pair formation, according to PCM/B3LYP/6-311++G**, PBE1PBE/6-311++G**, and MP2//HF/6-311++G*? quantum chemical calculations. AIM calculations revealed the essential role of the Li atom at all stages of the process.

Minisci aroylation of N-heterocycles using choline persulfate in water under mild conditions

Metal persulfate mediated thermal oxidative organic transformations invariably require a higher temperature and frequently use an organic solvent. The objective of this work was to develop persulfate mediated oxidative transformations that can be performed nearly at room temperature using water as a solvent. This report describes modified Minisci aroylation of isoquinolines with arylglyoxylic acids using choline persulfate and its pre-composition (choline acetate and K2S2O8) in water at 40 °C. A few other nitrogen heterocycles were also utilized affording various aroylated products in good to excellent yields. Unlike metal persulfate that could produce metal salt byproducts, a key feature of the chemistry reported herein includes the use of environmentally benign choline persulfate containing biodegradable choline as a counter-cation, the Minisci reaction demonstrated at 40 °C in water as the only solvent, and unconventional activation of persulfate. This journal is

Aroylation of Electron-Rich Pyrroles under Minisci Reaction Conditions

The development of Minisci acylation on electron-rich pyrroles under silver-free neutral conditions has been reported featuring the regioselective monoacylation of (NH)-free pyrroles. Unlike conventional Minisci conditions, the avoidance of any acid that could result in the polymerization of pyrroles was the key to success. The umpolung reactivity of the nucleophilic acyl radical, generated in situ from arylglyoxylic acid, could help explain the mechanism of product formation with electron-rich pyrroles. Alternatively, the nucleophilic substitution of the acyl radical on the electron-deficient pyrrole radical cation is proposed.