2666-14-0

Basic information

• Product Name: 1-HYDROXYETHYLIDENE-1,1-DIPHOSPHONIC ACID TRISODIUM SALT
• Synonyms: (1-hydroxyethylidene)bis-phosphonicacitrisodiumsalt;(1-hydroxyethylidene)diphosphonicacid,trisodiumsalt;(1-hydroxyethylidene)-diphosphonicacitrisodiumsalt;ethane-1-hydroxy-1,1-diphosphonicacid,trisodiumsalt;Phosphonicacid,(1-hydroxyethylidene)bis-,trisodiumsalt;trisodiumetidronate;trisodium hydrogen (1-hydroxyethylidene)bisphosphonate;1-Hydroxyethylidene-1,1-bis-(phosphonic acid) trisodium salt
• CAS NO: 2666-14-0
• Molecular Formula: C₂H₄O₇P₂*4Na
• Molecular Weight: 271.973732
• EINECS: 220-200-3
• Mol File: 2666-14-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 578.8°Cat760mmHg
• Flash Point: 303.8°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 8.34E-16mmHg at 25°C
• CAS DataBase Reference: 1-HYDROXYETHYLIDENE-1,1-DIPHOSPHONIC ACID TRISODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: 1-HYDROXYETHYLIDENE-1,1-DIPHOSPHONIC ACID TRISODIUM SALT(2666-14-0)
• EPA Substance Registry System: 1-HYDROXYETHYLIDENE-1,1-DIPHOSPHONIC ACID TRISODIUM SALT(2666-14-0)

Safety Data

• Hazardous Substances Data: 2666-14-0(Hazardous Substances Data)

Usage

General Description

1-Hydroxyethylidene-1,1-diphosphonic acid trisodium salt, also known as HEDP-Na3, is a chemical compound commonly used in the industrial and agricultural sectors. It is a powerful chelating agent and sequestering agent, used to prevent the formation of scale and corrosion in water treatment systems and in metal cleaning applications. HEDP-Na3 is also employed as a stabilizer and sequestrant in various detergent and cleaner formulations. Additionally, it has applications in the oil and gas industry, as well as in the formulation of personal care and cosmetic products. HEDP-Na3 is a low-toxicity, biodegradable chemical making it suitable for a wide range of industrial and consumer applications.

InChI:InChI=1/C2H8O7P2.3Na/c1-2(3,10(4,5)6)11(7,8)9;;;/h3H,1H3,(H2,4,5,6)(H2,7,8,9);;;/q;3*+1/p-3

Upstream product

• 64-19-7 acetic acid 
• 75-36-5 acetyl chloride 
• 30148-50-6 bis(trimethylsilyl)phosphonite 
• 6838-42-2 acetylphosphonic acid di(trimethylsilyl) ester 
• 2809-21-4 1-hydroxyethylene-(1,1-diphosphonic acid) 
• 141-43-5 ethanolamine 
• 106-89-8 epichlorohydrin 
• 109-83-1 (2-hydroxyethyl)(methyl)amine 

Downstream Products

• 34162-79-3 vinylidene-1,1-diphosphonic acid 

Relevant articles and documents

One-pot synthesis of phosphinylphosphonate derivatives and their anti-tumor evaluations

This paper reports on the synthesis of new hydroxymethylene-(phosphinyl)phosphonates (HMPPs). A methodology has been developed to propose an optimized one-pot procedure without any intermediate purifications. Various aliphatic and (hetero)aromatic HMPPs were synthesized in good to excellent yields (53–98%) and the influence of electron withdrawing/donating group substitution on aromatic substrates was studied. In addition, the one-pot synthesis of HMPP was monitored by31P NMR spectroscopy, allowing effective control of the end of the reaction and identification of all phosphorylated intermediate species, which enabled us to propose a reaction mechanism. Optimized experimental conditions were applied to the preparation of biological relevant aminoalkyl-HMPPs. A preliminary study of the complexation to hydroxyapatite (bone matrix) was carried out in order to verify its lower affinity towards bone compared to bisphosphonate molecules. Moreover, in vitro anti-tumor activity study revealed encouraging antiproliferative activities on three human cancer cell lines (breast, pancreas and lung).

Optimized synthesis of etidronate

The synthesis of Etidronate (as the disodium salt) by the reaction of acetic acid with phosphorus trichloride/phosphorus acid in methanesulfonic acid was studied and optimized. We showed that it is enough to use 3.2 equivalents of the phosphorus trichlori

Aminohydroxypropane esters of hydroxyethylidenebisphosphoric acid.

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