27317-59-5

Basic information

• Product Name: ethyl 3-ethoxy-3-iminopropionate
• Synonyms: ethyl 3-ethoxy-3-iminopropionate;ethyl-ethoxy-imido-propionate;3-Ethoxy-3-iminopropionic acid ethyl ester;3-Imino-3-ethoxypropionic acid ethyl ester;Ethyl β-imino-β-ethoxypropionate;Ethyl-β-imino-β-ethoxypropionate;β-Imino-β-ethoxypropionic acid ethyl ester;Einecs 248-400-6
• CAS NO: 27317-59-5
• Molecular Formula: C₇H₁₃NO₃
• Molecular Weight: 159.18302
• EINECS: 248-400-6
• Mol File: 27317-59-5.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 185.7 °C at 760 mmHg
• Flash Point: 66.1 °C
• Appearance: /
• Density: 1.05 g/cm³
• Vapor Pressure: 0.688mmHg at 25°C
• Refractive Index: 1.444
• Storage Temp.: 2-8°C
• PKA: 6.46±0.70(Predicted)
• CAS DataBase Reference: ethyl 3-ethoxy-3-iminopropionate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-ethoxy-3-iminopropionate(27317-59-5)
• EPA Substance Registry System: ethyl 3-ethoxy-3-iminopropionate(27317-59-5)

Safety Data

• Hazardous Substances Data: 27317-59-5(Hazardous Substances Data)

Usage

General Description

Ethyl 3-ethoxy-3-iminopropionate is a chemical compound with the molecular formula C8H17NO3. It is a derivative of ethyl iminopropionate, containing an ethoxy group attached to the third carbon of the propionate chain. ethyl 3-ethoxy-3-iminopropionate is commonly used in organic synthesis as a building block for the preparation of various pharmaceuticals and agrochemicals. It can also be used as a reagent in the production of fine chemicals and specialty materials. Additionally, ethyl 3-ethoxy-3-iminopropionate has potential applications in the field of medicinal chemistry, serving as a precursor for the design and synthesis of small molecule drugs targeting specific biological pathways.

InChI:InChI=1/C7H13NO3/c1-3-10-6(8)5-7(9)11-4-2/h8H,3-5H2,1-2H3/b8-6-

Upstream product

• 64-17-5 ethanol 
• 105-56-6 ethyl 2-cyanoacetate 
• 2318-25-4 ethyl 3-ethoxy-3-iminopropanoate hydrochloride 

Downstream Products

• 1162-85-2 3-ethoxy-5-(4-nitro-anilino)-isothiazole-4-carboxylic acid ethyl ester 
• 1238-08-0 diethyl (4-nitrophenyl)thiocarbamoylmalonate 
• 767-16-8 4-amino-6-hydroxy-2-methylpyrimidine 
• 57508-48-2 carbethoxyacetamidine hydrochloride 
• 63012-90-8 7-amino-2,3-dihydro-5H-thiazolo<3,2-a>-pyrimidin-5-one 
• 50551-10-5 ethyl amidinoacetate 
• 105-53-3 diethyl malonate 
• 96335-42-1 5-Amino-pyrazolo<1,5-a>pyrimidin-7(4H)-on 
• 129027-71-0 3-Amino-3-(phenylacetyl-hydrazono)-propionic acid ethyl ester 
• 126650-44-0 C₁₂H₁₄N₄O₄ 
• 126650-43-9 C₁₂H₁₄N₄O₄ 
• 126650-45-1 C₁₂H₁₃Cl₂N₃O₂ 
• 126650-42-8 C₁₂H₁₄ClN₃O₂ 
• 126650-41-7 C₁₃H₁₇N₃O₂ 

Relevant articles and documents

The structure modification of seven-membered aza-brigded neonicotinoids in order to investigate their impact on honey bees

In order to explore the relationship between the structure and the toxicity to honey bees of seven-membered aza-bridged neonicotinoids, 16 novel seven-membered aza-bridged neonicotinoid analogues are synthesized by replacing the pyridine ring, and changing the substituents on the pyridine ring, the electron-withdrawing group NO2 and the imidazole ring of our previously developed aza-bridged neonicotinoid 1-[(6-chloropyridin-3-yl)methyl)]-10-(2,5-dimethylphenyl)-9-nitro-2,3,5,6,7,8-hexahydro-1H-5,8-epiminoimidazo azepine (C-29). The insecticidal bioactivities against cowpea aphid (Aphis craccivora) and the bee toxicities of these compounds are tested. Some of the title compounds present good insecticidal activities against cowpea aphid. The results also show that some of the title compounds exhibit lower bee toxicity than that of C-29 and imidacloprid. This suggests that changing the substituents on the neonicotinoids can influence the toxicity toward honey bees of these analogues.

A New Synthesis of 2-Aminoindoles and 6-Aminopyrrolo[3,2- d ]pyrimidines from π-Deficient 1,2-Dihaloarenes and Geminal Enediamines

An efficient approach for the synthesis of fused 2-aminopyrroles via geminal enediamines and π-deficient 1,2-dihaloarenes is presented. The two-step methodology includes aromatic nucleophilic substitution of the activated halogen of dihaloarene with enediamine C-nucleophilic center followed by Cu-catalyzed intramolecular N-arylation. This approach allows access to a variety of 2-amino-6-nitroindoles and 6-aminopyrrolo[3,2-d]pyrimidines (including N-mono- and N,N-disubstituted) in moderate and good yields under mild conditions.

SUBSTITUTED HYDRAZIDE COMPOUNDS AND USE THEREOF

The invention relates to substituted hydrazide compounds as shown by general formula I, including geometrical isomers, pharmaceutically acceptable salts, hydrates, solvates or prodrugs thereof, and use of the same, wherein the substitutents Ar and R have the same meanings as given in the Description. The invention further relates to the use of compounds of general formula I in the preparation of medicament for the treatment and/or prevention of cancer and other proliferative diseases.