27542-85-4

Basic information

• Product Name: 2-Propenoic acid, 3-[4-(acetyloxy)phenyl]-, (E)-
• Synonyms: p-acetoxy-cinnamic acid;4-acetyloxycinnamic acid;p-Acetoxycinnamic acid;4-acetoxycinnamic acid;3-(4-ACETOXY-PHENYL)-ACRYLIC ACID;3-(4-Acetoxyphenyl)-acrylic acid;(2E)-3-[4-(acetyloxy)phenyl]-2-propenoic acid;4-ACETYLCOUMARIC ACID
• CAS NO: 27542-85-4
• Molecular Formula: C11H10O4
• Molecular Weight: 206.198
• Mol File: 27542-85-4.mol
• Article Data: 63

Chemical Properties

• Melting Point: 208.0 to 212.0 °C
• CAS DataBase Reference: 2-Propenoic acid, 3-[4-(acetyloxy)phenyl]-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-[4-(acetyloxy)phenyl]-, (E)-(27542-85-4)
• EPA Substance Registry System: 2-Propenoic acid, 3-[4-(acetyloxy)phenyl]-, (E)-(27542-85-4)

Safety Data

• Hazardous Substances Data: 27542-85-4(Hazardous Substances Data)

Usage

General Description

2-Propenoic acid, 3-[4-(acetyloxy)phenyl]-, (E)- is a chemical compound that belongs to the class of 2-propenoic acids. It is also known as 3-(4-acetoxyphenyl) acrylic acid. 2-Propenoic acid, 3-[4-(acetyloxy)phenyl]-, (E)- is characterized by its E configuration and a phenyl group, as well as an acetyloxy group attached to the phenyl ring. It has potential applications in various fields such as pharmaceuticals, polymers, and materials science. Additionally, it is important to handle this compound with care as it may have hazardous properties.

Upstream product

• 127-09-3 sodium acetate 
• 108-24-7 acetic anhydride 
• 123-08-0 4-hydroxy-benzaldehyde 
• 463-51-4 Ketene 
• 67-64-1 acetone 
• 7400-08-0 para-coumaric acid 
• 64-19-7 acetic acid 
• 7361-92-4 ethyl 3-(4-hydroxyphenyl)prop-2-enoate 
• 7400-08-0 p-Coumaric Acid 
• 71-43-2 benzene 
• 878-00-2 4-formylphenyl acetate 
• 141-82-2 malonic acid 
• 75-36-5 acetyl chloride 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 

Downstream Products

• 53901-95-4 p-acetoxycinnamoyl chloride 
• 50363-92-3 cis-p-Acetoxyzimtsaeure 
• 377047-67-1 (E)-3-(4-Acetoxy-phenyl)-acrylic acid (E)-4-(4-hydroxy-3-methoxy-phenyl)-2-oxo-but-3-enyl ester 
• 2628-17-3 4-Vinylphenol 
• 1202495-53-1 1-hydroxy-3-(4-acetoxyphenyl)-2-propen 
• 66432-08-4 C₁₁H₁₁NO₃ 

Relevant articles and documents

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TRPV3 inhibitor and preparation method thereof

The invention discloses a TRPV3 inhibitor. The TRPV3 inhibitor is formed by sequentially connecting an R1 group, an R group and an R2 group, and the molecular structural general formula of the TRPV3 inhibitor is shown as a formula 1, wherein the structural formula of the R1 group is represented by a formula 2, R3 is selected from any one of -H, -OAc, -OH, a halogen group, -F3CO or a group containing a benzenesulfonyloxy group, and R4 is selected from any one of -H, -OAc or -OH; R1 and R2 are selected from alkyl or formula 3, R5 is selected from C or N, R6 is selected from any one of hydrogen, alkyl, halogen group or trifluoromethyl, R7 is selected from any one of hydrogen, halogen group, cyano group, nitro group or trifluoromethoxy group, and R8 is selected from hydrogen or halogen group. The invention also discloses a preparation method and application of the TRPV3 inhibitor. The TRPV3 inhibitor disclosed by the invention can specifically inhibit a TRPV3 ion channel and has huge scientific research and clinical values.

Dual Nickel/Ruthenium Strategy for Photoinduced Decarboxylative Cross-Coupling of α,β-Unsaturated Carboxylic Acids with Cycloketone Oxime Esters

Herein, a dual nickel/ruthenium strategy is developed for photoinduced decarboxylative cross-coupling between α,β-unsaturated carboxylic acids and cycloketone oxime esters. The reaction mechanism is distinct from previous photoinduced decarboxylation of α,β-unsaturated carboxylic acids. This reaction might proceed through a nickelacyclopropane intermediate. The C(sp2)-C(sp3) bond constructed by the aforementioned reaction provides an efficient approach to obtaining various cyanoalkyl alkenes, which are synthetically valuable organic skeletons in organic and medicinal chemistry, under mild reaction conditions. The protocol tolerates many critical functional groups and provides a route for the modification of complex organic molecules.