284672-84-0Relevant articles and documents
Design, synthesis and biological evaluation: 5-amino-1h-pyrazole-1-carbonyl derivatives as fgfr inhibitors
Zhang, Yan,Yu, Niefang
, p. 1330 - 1341 (2020/10/06)
Background: Fibroblast growth factors (FGFs) and their high affinity receptors (FGFRs) play a major role in cell proliferation, differentiation, migration, and apoptosis. Aberrant FGFR signaling pathway might accelerate development in a broad panel of mal
N-Heterocyclic Carbenes as a Robust Platform for Surface-Enhanced Raman Spectroscopy
Dejesus, Joseph F.,Trujillo, Michael J.,Camden, Jon P.,Jenkins, David M.
supporting information, p. 1247 - 1250 (2018/02/09)
Surface-enhanced Raman spectroscopy (SERS) underpins a wide range of commercial and fundamental applications. SERS often relies on ligands, usually thiols, bound to a noble metal surface. The difficulty of straightforward thiol synthesis combined with their instability on surfaces highlights the need for alternative ligand design. We present the first example of SERS utilizing N-heterocyclic carbene ligands. A general three step synthesis is presented for functionalized NHC-CO2 adducts. These ligands are deposited on SERS-active gold film-over-nanosphere substrates (AuFONs) in solvent-free and base-free conditions, which prevents fouling. The resulting films are found to be robust and capable of postsynthetic modifications.
Soluble polymer-supported synthesis of a benzimidazole library
Chi, Yu-Chung,Sun, Chung-Ming
, p. 591 - 594 (2007/10/03)
The synthesis of benzimidazole 1 using a liquid phase approach is described. Aromatic substitution of immobilized o-fluoronitrobenzene 2 with various amines to o-nitroaniline derivatives 3 is carried out in methylene chloride. Reduction of the aromatic nitro group, followed by subsequent cyclization/elimination gives the benzimidazole skeleton. The crude library members obtained are of high yields and chemical purities after cleavage.
