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2973-19-5

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2973-19-5 Usage

Chemical Properties

Off-White Solid

Check Digit Verification of cas no

The CAS Registry Mumber 2973-19-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,9,7 and 3 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 2973-19:
(6*2)+(5*9)+(4*7)+(3*3)+(2*1)+(1*9)=105
105 % 10 = 5
So 2973-19-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H6ClNO3/c8-4-5-3-6(9(11)12)1-2-7(5)10/h1-3,10H,4H2

2973-19-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(Chloromethyl)-4-nitrophenol

1.2 Other means of identification

Product number -
Other names 2-(chloromethyl)-4-nitrophenol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2973-19-5 SDS

2973-19-5Relevant articles and documents

A Ligand-Directed Nitrophenol Carbonate forTransient in situ Bioconjugation and Drug Delivery

Burt, Anthony J.,Ahmadvand, Parvaneh,Opp, Larissa K.,Ryan, Austin T.,Kang, ChulHee,Mancini, Rock J.

supporting information, p. 2004 - 2009 (2020/10/19)

Here we report the first use of ligand-directed proximity accelerated bioconjugation chemistry in the tandem delivery and release of a therapeutic payload. To do this, we designed a nitrophenol carbonate for ligand-directed in situ bioconjugation of a prodrug payload to a protein. The transient nature of our conjugation chemistry renders the protein a depot for time-dependent release of active drug following hydrolysis and self-immolation. In our model system, using an immunostimulant prodrug, biotin ligand, and avidin protein, we observe release of bioavailable immunostimulant both spectroscopically and with an immune cell line over 48 h. Avidin co-crystalized with the nitrophenolate directing group verified the binding pose of the ligand and offered insight into the mechanism of in situ bioconjugation. Overall, this scaffold warrants further investigation for the time-dependent delivery of therapeutics and use in protein ligand pairs beyond biotin and avidin used for this work.

Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell Lines

Yang, Eugene Guorong,Mustafa, Nurulhuda,Tan, Eng Chong,Poulsen, Anders,Ramanujulu, Pondy Murugappan,Chng, Wee Joo,Yen, Jeffrey J. Y.,Dymock, Brian W.

, p. 8233 - 8262 (2016/10/03)

Blockage of more than one oncoprotein or pathway is now a standard approach in modern cancer therapy. Multiple inhibition is typically achieved with two or more drugs. Herein, we describe a pharmacophore merging strategy combining the JAK2/FLT3 inhibitor pacritnib with the pan-HDAC inhibitor, vorinostat, to create bispecific single molecules with both JAK and HDAC targeted inhibition. A preferred ether hydroxamate, 51, inhibits JAK2 and HDAC6 with low nanomolar potency, is 50-fold selective for JAK2 in a panel of 97 kinases. Broad cellular antiproliferative potency is supported by demonstration of JAK-STAT and HDAC pathway blockade in several hematological cell lines, inhibition of colony formation in HEL cells, and analysis of apoptosis. This study provides new tool compounds for further exploration of dual JAK-HDAC pathway inhibiton achieved with a single molecule.

Vanadium(V) complexes of polydentate amino alcohols: Fine-tuning complex properties

Crans, Debbie C.,Boukhobza, Iman

, p. 8069 - 8078 (2007/10/03)

In aqueous solution, the stability, the structure, and the lability of 12 vanadium(V) complexes were determined and related to the amino alcohol ligand properties. The amino alcohols were chosen to maintain a five- coordinate vanadium geometry in the vanadium complex and were based on diethanolamine as the parent ligand. Apparent and composite stability constants were determined for all 12 complexes. Selected complexes were further examined to determine solution structure, lability, and thermodynamic properties. We empirically show that the formation constants for the series of 12 complexes, when plotted as a function of the pK(a) value for the protonated amino alcohol, generate a curve that initially increases as the pK(a) value increases and then decreases as the pK(a) value continues to increase. The observed associations suggest that the electron-donating capacity of the amino alcohol plays a major role in complex stability; however, metal coordination number, sterics in the amino alcohol, and solvation also are found to affect the stability. Determination of the thermodynamic parameters of selected complexes showed that the enthalpic component was the major contributor to the stability of the complex, but that the entropic component opposed this term. A series of studies was conducted to examine whether the lability of these complexes varied from the parent complexes. Unfortunately, the variation in the lability of these complexes was much less than the variation in complex stability. In summary, these studies describe quantitatively the variation in complex stability and lability as the structure of amino alcohol is modified and explain why some complexes show less stability than predicted on the basis of the pK(a) value. In short, this study provides valuable information for the design of additional vanadium complexes with specific properties.

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