3002-01-5

Basic information

• Product Name: Dibenzyltindichloride
• Synonyms: Dibenzyldichlorostannane;Dibenzyltin(IV) dichloride;bis(benzyl)-dichloro-stannane;dichloro-bis(phenylmethyl)stannane
• CAS NO: 3002-01-5
• Molecular Formula: C₁₄H₁₄Cl₂Sn
• Molecular Weight: 371.88
• Mol File: 3002-01-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 395.4°Cat760mmHg
• Flash Point: 193°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 4.19E-06mmHg at 25°C
• CAS DataBase Reference: Dibenzyltindichloride(CAS DataBase Reference)
• NIST Chemistry Reference: Dibenzyltindichloride(3002-01-5)
• EPA Substance Registry System: Dibenzyltindichloride(3002-01-5)

Safety Data

• Hazardous Substances Data: 3002-01-5(Hazardous Substances Data)

Usage

InChI:InChI=1/2C7H7.2ClH.Sn/c2*1-7-5-3-2-4-6-7;;;/h2*2-6H,1H2;2*1H;/q;;;;+2/p-2/rC14H14Cl2Sn/c15-17(16,11-13-7-3-1-4-8-13)12-14-9-5-2-6-10-14/h1-10H,11-12H2

Upstream product

• 10113-29-8 tetrabenzyltin 
• 7440-31-5 stannane 
• 100-44-7 benzyl chloride 
• 7719-09-7 thionyl chloride 
• 7647-01-0 hydrogenchloride 
• 35569-19-8 dibenzyl-diphenyl stannane 
• 67-66-3 chloroform 
• 61726-33-8 dibenzyldibutylstannane 
• 56-23-5 tetrachloromethane 
• 7440-31-5 tin 
• 865-49-6 chloroform-d1 
• 3151-41-5 tribenzyltin(IV) chloride 

Downstream Products

• 113765-52-9 bis(diethyldithiophosphinato)dibenzyltin(IV) 
• 1111-45-1 {(C₆H₅CH₂)2Sn}4 
• 108443-15-8 (C₆H₅CH₂)2Sn(OSO₂C₆H₄CH₃)2 
• 79075-67-5 bisbenzyltin(IV) bistrifluoroacetate 
• 221363-74-2 (C₆F₅)2Sn(CH₂C₆H₅)2 
• 318956-43-3 (C₆H₅CH₂)2Sn(OC(O)CH₂C₆H₄NHC₆H₃Cl₂)2 
• 428507-13-5 [(PhCH₂)2SnCl(S₂CNPh₂)] 
• 428507-14-6 [(PhCH₂)2SnCl(S₂CNPh(COCH₃))] 
• 1066-45-1 trimethyltin(IV)chloride 
• 861242-17-3 (C₆H₅CH₂)2Sn(SC₆H₄CO₂H)2 
• 886973-73-5 [(PhCH₂)2SnCl(S-C₃H₂N₄-S)SnCl(PhCH₂)2] 
• 915772-94-0 bis(monomethyl phthalate)dibenzyltin 

Relevant articles and documents

Diversity of complexes based on p-nitrobenzoylhydrazide, benzoylformic acid and diorganotin halides or oxides self-assemble: Cytotoxicity, the induction of apoptosis in cancer cells and DNA-binding properties

Eight organotin(IV) complexes (C1-C8) have been synthesized and characterized by elemental analysis, fourier transform infrared spectroscopy (FT-IR), multinuclear nuclear magnetic resonance (1H, 13C and 119Sn NMR), high resolution mass spectroscopy (HRMS) and single crystal X-ray structural analysis. Crystallographic data show that C1 was a tetranuclear 16-membered macrocycle complex, C2-C4 and C7 were centrosymmetric dimer distannoxane and there was a Sn2O2 four-membered ring in the middle of the molecule, respectively, C5 and C6 are monoorganotin complexes due to the dehydroalkylation effect during the reaction, while C8 forms a one-dimensional chain structure. The cytotoxicity of all complexes were tested by 3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetrazoliumromide (MTT) assays against three human tumor cell lines NCI-H460, MCF-7 and HepG2. The dibutyltin complex C2 has been shown to be more potent antitumor agents than other complexes and carboplatin. Cell apoptosis study of C2 with the high activity on HepG2 and MCF-7 cancer cell lines was investigated by flow cytometry, it was shown that the antitumor activity of C2 was related to apoptosis, but it has different cell cycle arrest characteristics from platinum compounds, and the proliferation was inhibited by blocking cells in S phase. The DNA binding activity of the C2 was studied by UV–visible absorption spectrometry, fluorescence competitive, viscosity measurements and gel electrophoresis, results shown C2 can be well embedded in the double helix of DNA and cleave DNA.

Alkyl tin compound

An alkyl tin compound having an alkyl group bound to a tin atom, wherein the alkyl group is a branched alkyl group or an alkyl group substituted by a cyclic group, the branched alkyl group is branched at at least one carbon atom among the first to third carbon atoms as counted from the tin atom, and the alkyl group substituted by a cyclic group is an alkyl group in which the cyclic group is bound to at least one carbon atom among the first to third carbon atoms as counted from the tin atom.

Process for the preparation of organotin compounds useful as cytotoxic agents

The present invention is drawn to complexes of dibenzyl-organotin compounds having nitrogen or sulfur containing heterocyclic ligands. Said complexes are useful as cytotoxic agents.