31560-20-0Relevant articles and documents
PYRROLO PYRIMIDINONE COMPOUND
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, (2021/09/01)
PROBLEM TO BE SOLVED: To provide a novel compound that has inhibitory action on prolyl hydroxylases (PHDs) and is useful as a treatment agent for inflammatory bowel diseases such as ulcerative colitis. SOLUTION: This invention relates to a pyrrolo pyrimidinone compound represented by the formula (I) or a pharmacologically acceptable salt thereof. The compound or a pharmacologically acceptable salt thereof has inhibitory action on prolyl hydroxylases and is useful as a treatment agent for inflammatory bowel diseases such as ulcerative colitis. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT
Cyclopropenone catalyzed substitution of alcohols with mesylate ion
Nacsa, Eric D.,Lambert, Tristan H.
supporting information, p. 38 - 41 (2013/03/28)
The cyclopropenone catalyzed nucleophilic substitution of alcohols by methanesulfonate ion with inversion of configuration is described. This work provides an alternative to the Mitsunobu reaction that avoids the use of azodicarboxylates and generation of hydrazine and phosphine oxide byproducts. This transformation is shown to be compatible with a range of functionality. A cyclopropenone scavenge strategy is demonstrated to aid purification.
Asymmetric synthesis of α-branched primary amines on solid support via novel hydrazine resins
Enders, Dieter,Kirchhoff, Jan H.,Koebberling, Johannes,Peiffer, Thomas H.
, p. 1241 - 1244 (2007/10/03)
Matrix presented Two novel chiral hydrazine resins for asymmetric solid-phase synthesis have been developed. The enantiopure β-methoxyamino auxiliaries, derived from frans-4-hydroxy-(S) -proline and (R) -leucine, were attached to Merrifield resin and transformed into their corresponding hydrazines. Immobilization of various aldehydes, followed by 1,2-addition of organolithium reagents to the resulting enantiopure hydrazones and reductive cleavage from the solid support, furnished α-branched amines, which were isolated as their corresponding amides in good overall yields and enantiomeric excesses of up to 86%.