317-46-4

Basic information

• Product Name: 2-FLUORO-3-NITROBENZOIC ACID
• Synonyms: Benzoic acid,2-fluoro-3-nitro-;2-FLUORO-3-NITROBENZOIC ACID;2-Fluoro-3-nitrobenzoic acid+B244;2-Fluoro-3-nitrobenzoic acid 99%;3-Carboxy-2-fluoronitrobenzene;3-Pyridinecarboxylic acid, 4-aMino-
• CAS NO: 317-46-4
• Molecular Formula: C₇H₄FNO₄
• Molecular Weight: 185.11
• EINECS: 1312995-182-4
• Product Categories: Fluorine series;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 317-46-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 347.6 °C at 760 mmHg
• Flash Point: 164 °C
• Appearance: /Solid
• Density: 1.568 g/cm³
• Vapor Pressure: 2.01E-05mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: 2-8°C
• Solubility: DMSO (Sparingly), Methanol (Slightly)
• PKA: 2.32±0.20(Predicted)
• Water Solubility: Slightly soluble in water.
• Sensitive: Air Sensitive
• Stability: Hygroscopic
• CAS DataBase Reference: 2-FLUORO-3-NITROBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-3-NITROBENZOIC ACID(317-46-4)
• EPA Substance Registry System: 2-FLUORO-3-NITROBENZOIC ACID(317-46-4)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25
• Hazardous Substances Data: 317-46-4(Hazardous Substances Data)

Usage

Description

2-Fluoro-3-nitrobenzoic acid is a light yellow crystalline powder that serves as a crucial intermediate in the synthesis of various organic compounds, pharmaceuticals, agrochemicals, and dyes due to its unique chemical properties.

Uses

Used in Organic Synthesis:
2-Fluoro-3-nitrobenzoic acid is used as a key intermediate for the production of various organic compounds. Its fluorinated and nitro-substituted aromatic structure makes it a versatile building block in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-fluoro-3-nitrobenzoic acid is utilized as a starting material for the development of new drugs. Its unique chemical structure allows for the creation of novel therapeutic agents with potential applications in treating various diseases and medical conditions.
Used in Agrochemicals:
2-Fluoro-3-nitrobenzoic acid is employed as a vital component in the formulation of agrochemicals, such as pesticides and herbicides. Its chemical properties contribute to the effectiveness of these products in controlling pests and promoting crop growth.
Used in Dye Industry:
In the dye industry, 2-fluoro-3-nitrobenzoic acid is used as a raw material for the production of various dyes. Its light yellow crystalline form and chemical properties enable the creation of a wide range of colorants for use in different applications, including textiles, plastics, and printing inks.

InChI:InChI=1/C7H4FNO4/c8-6-4(7(10)11)2-1-3-5(6)9(12)13/h1-3H,(H,10,11)

Upstream product

• 124-38-9 carbon dioxide 
• 1493-27-2 ortho-nitrofluorobenzene 
• 13073-29-5 2-methyl-6-nitrophenol 
• 95-48-7 ortho-cresol 
• 1214328-20-7 2-fluoro-3-nitrobenzonitrile 
• 96516-29-9 2-fluoro-3-nitrobenzaldehyde 
• 437-86-5 2-fluoro-3-nitrotoluene 
• 95-52-3 2-Fluorotoluene 
• 445-29-4 o-fluoro-benzoic acid 

Downstream Products

• 1254567-33-3 (3-amino-2-fluorophenyl)(5-bromo-1H-pyrrolo[2,3-b]pyridin- 3-yl)methanone 
• 1312942-00-9 (5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)(2-fluoro-3-nitrophenyl)methanone 
• 1312942-01-0 N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-fluoro-phenyl]-2-fluoro-benzenesulfonamide 
• 1312940-70-7 2-fluoro-N-{2-fluoro-3-[5-(2-methoxy-pyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-phenyl}-benzenesulfonamide 
• 1352609-95-0 1-(2-fluoro-3-nitrophenyl)-N,N-dimethylmethanamine 
• 1307272-00-9 N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(4-methyltetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-1-propanesulfonamide 
• 1307271-99-3 {3-[5-(2-chloro-4-pyrimidinyl)-2-(4-methyltetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}amine 
• 1307271-98-2 2-propen-1-yl {3-[5-(2-chloro-4-pyrimidinyl)-2-(4-methyltetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}carbamate 
• 1307271-96-0 1,1-dimethylethyl 4-(4-{2-fluoro-3-[(propylsulfonyl)amino]phenyl}-5-{2-[(2-hydroxyethyl)amino]-4-pyrimidinyl}-1,3-thiazol-2-yl)-4-methyl-1-piperidinecarboxylate 
• 1307271-95-9 N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1,4-dimethyl-4-piperidinyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-1-propanesulfonamide trifluoroacetate 
• 1307271-93-7 N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(4-methyl-4-piperidinyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-1-propanesulfonamide 
• 1307271-92-6 1,1-dimethylethyl 4-(5-(2-amino-4-pyrimidinyl)-4-{2-fluoro-3-[(propylsulfonyl)amino]phenyl}-1,3-thiazol-2-yl)-4-methyl-1-piperidinecarboxylate 
• 1307271-91-5 1,1-dimethylethyl 4-(5-(2-chloro-4-pyrimidinyl)-4-{2-fluoro-3-[(propylsulfonyl)amino]phenyl}-1,3-thiazol-2-yl)-4-methyl-1-piperidinecarboxylate 
• 1307271-90-4 N-{3-[(2-chloro-4-pyrimidinyl)acetyl]-2-fluorophenyl}-1-propanesulfonamide 

Relevant articles and documents

Synthesis method of 2-fluoro-3-nitrobenzoic acid intermediate raw material

The invention discloses a synthesis method of a 2-fluoro-3-nitrobenzoic acid intermediate raw material. The invention provides a novel synthesis route, and an important medical intermediate can be rapidly and conveniently prepared from cheap and easily available raw materials. The process method comprises the following steps: starting from o-methylphenol, carrying out nitration reaction to selectively generate a key intermediate 2-methyl-6-nitrophenol, carrying out hydroxyl chlorination to generate 2-chloro-3-nitrotoluene, then carrying out fluorination reaction to generate 2-fluoro-3-nitrotoluene, and finally oxidizing methyl under the action of an oxidant to generate 2-fluoro-3-nitrobenzoic acid. The method is not only high in yield, but also suitable for large-scale production.

IMINOTETRAHYDROPYRIMIDINONE DERIVATIVES AS PLASMEPSIN V INHIBITORS

A series of 2-imino-6-methyltetrahydropyrimidin-4(lH)-one derivatives, substituted in the 6-position by a phenyl moiety which in turn is meta-substituted by an optionally substituted unsaturated fused bicyclic ring system containing at least one nitrogen atom, being selective inhibitors of plasmepsin V activity, are beneficial as pharmaceutical agents, especially in the treatment of malaria.

COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR

Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on each of B-Raf, B-Raf V600E and c-Raf-1 protein kinase. In certain aspects and embodiments, the described compounds are active in inhibiting proliferation of a Ras mutant cell line. Also described are methods of use thereof to treat diseases and conditions, including melanoma, glioma, glioblastoma, pilocytic astrocytoma, liver cancer, biliary tract cancer, cholangiocarcinoma, colorectal cancer, lung cancer, bladder cancer, gallbladder cancer, breast cancer, pancreatic cancer, thyroid cancer, kidney cancer, ovarian cancer, adrenocortical cancer, prostate cancer, gastrointestinal stromal tumors, medullary thyroid cancer, tumor angiogenesis, acute myeloid leukemia, chronic myelomonocytic leukemia, childhood acute lymphoblastic leukemia, plasma cell leukemia, and multiple myeloma.