32316-46-4

Basic information

• Product Name: Cyclohexanone, 2-(1-oxopropyl)-
• CAS NO: 32316-46-4
• Molecular Formula: C9H14O2
• Molecular Weight: 154.209
• Mol File: 32316-46-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Cyclohexanone, 2-(1-oxopropyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanone, 2-(1-oxopropyl)-(32316-46-4)
• EPA Substance Registry System: Cyclohexanone, 2-(1-oxopropyl)-(32316-46-4)

Safety Data

• Hazardous Substances Data: 32316-46-4(Hazardous Substances Data)

Upstream product

• 670-80-4 4-cyclohexen-1-ylmorpholine 
• 67-66-3 chloroform 
• 79-03-8 propionyl chloride 
• 121-44-8 triethylamine 
• 108-94-1 cyclohexanone 
• 105-37-3 Ethyl propionate 
• 6651-36-1 1-(Trimethylsilyloxy)cyclohexene 
• 123-62-6 propionic acid anhydride 
• 123-75-1 pyrrolidine 
• 4513-77-3 2-cyanocyclohexanone 
• 925-90-6 ethylmagnesium bromide 

Downstream Products

• 1189582-78-2 methyl 4-[(3-ethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)methyl]benzoate 
• 107292-65-9 2-(4,9-Dihydro-3H-pyrido<3,4-b>indol-1-yl)-1-ethylcyclohexanol 
• 108-94-1 cyclohexanone 
• 1919-00-2 4,5,6,7-tetrahydro-3-methylbenzofuran 
• 88267-99-6 2-(4-Benzyl-piperazin-1-yl)-4-ethyl-5,6,7,8-tetrahydro-quinazoline; compound with (Z)-but-2-enedioic acid 
• 853301-00-5 N-[1-(2-oxocylohexylidene)propyl]-L-valine diethylamide 
• 853300-93-3 N-(2-propionyl-1-cyclohexenyl)-L-valine diethylamide 
• 95546-70-6 (1-Amino-5-ethyl-6,7,8,9-tetrahydro-thieno[2,3-c]isoquinolin-2-yl)-phenyl-methanone 
• 95546-61-5 (4-Cyano-1-ethyl-5,6,7,8-tetrahydro-isoquinolin-3-ylsulfanyl)-acetic acid 
• 380491-63-4 N²-(4-ethyl-5,6,7,8-tetrahydroquinazolin-2-yl)-1,3-benzothiazol-2-amine 
• 99564-83-7 2-Trimethylsiloxy-3-<1-(trimethylsiloxy)propyliden>-1-cyclohexen 
• 95546-97-7 1-ethyl-4-cyano-5,6,7,8-tetrahydro-3(2H)-isoquinolinethione 
• 107292-41-1 1-<2-<<2-(1H-Indol-3-yl)ethyl>amino>-1-cyclohexen-1-yl>propanone 

Relevant articles and documents

Pyrazolyl-pyrimidones inhibit the function of human solute carrier protein SLC11A2 (hDMT1) by metal chelation

Solute carrier proteins (SLCs) control fluxes of ions and molecules across biological membranes and represent an emerging class of drug targets. SLC11A2 (hDMT1) mediates intestinal iron uptake and its inhibition might be used to treat iron overload diseases such as hereditary hemochromatosis. Here we report a micromolar (IC50 = 1.1 μM) pyrazolyl-pyrimidone inhibitor of radiolabeled iron uptake in hDMT1 overexpressing HEK293 cells acting by a non-competitive mechanism, which however does not affect the electrophysiological properties of the transporter. Isothermal titration calorimetry, competition with calcein, induced precipitation of radioactive iron and cross inhibition of the unrelated iron transporter SLC39A8 (hZIP8) indicate that inhibition is mediated by metal chelation. Mapping the chemical space of thousands of pyrazolo-pyrimidones and similar 2,2′-diazabiaryls in ChEMBL suggests that their reported activities might partly reflect metal chelation. Such metal chelating groups are not listed in pan-assay interference compounds (PAINS) but should be checked when addressing SLCs.

New bicyclic dioxanes, their preparation and their use as organoleptic compounds

The present invention relates to novel 1,3-dioxane derivatives of formula (I) wherein each of R1 and R2 is a hydrogen atom, R3 and R4 are independently a hydrogen atom, a linear or branched C1-C6 alkyl group, or a linear or branched C2-C6 alkenyl group, and R5 is a linear or branched C1-C6 alkyl group, a linear or branched C2-C6 alkenyl group or a (CH2)0-2 - aryl group, and R6 and R7 are independently a hydrogen atom, a linear or branched C1-C6 alkyl group, a linear or branched C2-C6 alkenyl group or a (CH2)0-2 - aryl group, or R6 and R7 together with the carbon atom to which they are attached form a C5-C6 cycloalkyl group or a C5-C6 cycloalkenyl group, substituted or not; their preparation and their use as organoleptic compounds.

Palladium-catalyzed intramolecular addition of 1,3-diones to unactivated olefins [1]

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