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328-39-2

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328-39-2 Usage

Chemical Properties

White crystalline powder

Uses

DL-Leucine is a racemic mixture of the D- and L- enantiomers of Leucine. DL-Leucine is used to form benzimidazole and pyrimidine hydroxy azo dyes with various transition metals. DL-Leucine may be used for the evaluation of chiral amino acid separation techniques.DL-Leucine is used for the following applications:Used as a standard for the measurement of free amino acidsUsed in the process of tritiated leucine uptakeUsed in solution preparation (various organics were used in different combinations and concentrations to model complex surface tension effects, DL-Leucine is one of them). It is chosen due to its presence in atmospheric aerosols and ice nucleation activity as well as for its surfactant character

Definition

ChEBI: A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isobutyl group.

Check Digit Verification of cas no

The CAS Registry Mumber 328-39-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,2 and 8 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 328-39:
(5*3)+(4*2)+(3*8)+(2*3)+(1*9)=62
62 % 10 = 2
So 328-39-2 is a valid CAS Registry Number.
InChI:InChI=1/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)

328-39-2 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (L0028)  DL-Leucine  >98.0%(T)

  • 328-39-2

  • 25g

  • 270.00CNY

  • Detail
  • Alfa Aesar

  • (A10590)  DL-Leucine, 99%   

  • 328-39-2

  • 50g

  • 502.0CNY

  • Detail
  • Alfa Aesar

  • (A10590)  DL-Leucine, 99%   

  • 328-39-2

  • 250g

  • 2022.0CNY

  • Detail
  • Alfa Aesar

  • (A10590)  DL-Leucine, 99%   

  • 328-39-2

  • 1000g

  • 6621.0CNY

  • Detail
  • Sigma

  • (L7875)  DL-Leucine  ≥99% (HPLC)

  • 328-39-2

  • L7875-25G

  • 480.87CNY

  • Detail
  • Sigma

  • (L7875)  DL-Leucine  ≥99% (HPLC)

  • 328-39-2

  • L7875-50G

  • 882.18CNY

  • Detail
  • Sigma

  • (L7875)  DL-Leucine  ≥99% (HPLC)

  • 328-39-2

  • L7875-100G

  • 1,518.66CNY

  • Detail
  • Vetec

  • (V900376)  DL-Leucine  Vetec reagent grade, 99%

  • 328-39-2

  • V900376-50G

  • 170.82CNY

  • Detail
  • Vetec

  • (V900376)  DL-Leucine  Vetec reagent grade, 99%

  • 328-39-2

  • V900376-250G

  • 749.97CNY

  • Detail

328-39-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name leucine

1.2 Other means of identification

Product number -
Other names 2-Amino-4-methylpentanoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:328-39-2 SDS

328-39-2Relevant articles and documents

Rational engineering ofAcinetobacter tandoiiglutamate dehydrogenase for asymmetric synthesis ofl-homoalanine through biocatalytic cascades

Diao, Shiqing,Jiang, Shuiqin,Liu, Yan,Sun, Yangyang,Wang, Hualei,Wang, Liuzhu,Wei, Dongzhi

, p. 4208 - 4215 (2021/06/30)

l-Homoalanine, a useful building block for the synthesis of several chiral drugs, is generally synthesized through biocascades using natural amino acids as cheap starting reactants. However, the addition of expensive external cofactors and the low efficiency of leucine dehydrogenases towards the intermediate 2-ketobutyric acid are two major challenges in industrial applications. Herein, a dual cofactor-dependent glutamate dehydrogenase fromAcinetobacter tandoii(AtGluDH) was identified to help make full use of the intracellular pool of cofactors when using whole-cell catalysis. Through reconstruction of the hydrophobic network between the enzyme and the terminal methyl group of the substrate 2-ketobutyric acid, the strict substrate specificity ofAtGluDH towards α-ketoglutarate was successfully changed, and the activity obtained by the most effective mutant (K76L/T180C) was 17.2 times higher than that of the wild-type protein. A three-enzyme co-expression system was successfully constructed in order to help release the mass transfer restriction. Using 1 Ml-threonine, which is close to the solubility limit, we obtained a 99.9% yield ofl-homoalanine in only 3.5 h without adding external coenzymes to the cascade, giving 99.9% ee and a 29.2 g L?1h?1space-time yield. Additionally, the activities of the engineeredAtGluDH towards some other hydrophobic amino acids were also improved to 1.1-11.2 fold. Therefore, the engineering design of some dual cofactor-dependent GluDHs could not only eliminate the low catalytic activity of unnatural substrates but also enhance the cofactor utilization efficiency of these enzymes in industrial applications.

Synthesis of Unprotected 2-Arylglycines by Transamination of Arylglyoxylic Acids with 2-(2-Chlorophenyl)glycine

Inada, Haruki,Shibuya, Masatoshi,Yamamoto, Yoshihiko

, p. 11047 - 11059 (2020/10/12)

The transamination of α-keto acids with 2-phenylglycine is an effective methodology for directly synthesizing unprotected α-amino acids. However, the synthesis of 2-arylglycines by transamination is problematic because the corresponding products, 2-arylglycines, transaminate the starting arylglyoxylic acids. Herein, we demonstrate the use of commercially available l-2-(2-chlorophenyl)glycine as the nitrogen source in the transamination of arylglyoxylic acids, producing the corresponding 2-arylglycines without interference from the undesired self-transamination process.

Direct Synthesis of Free α-Amino Acids by Telescoping Three-Step Process from 1,2-Diols

Inada, Haruki,Shibuya, Masatoshi,Yamamoto, Yoshihiko

supporting information, p. 709 - 713 (2019/01/25)

A practical telescoping three-step process for the syntheses of α-amino acids from the corresponding 1,2-diols has been developed. This process enables the direct synthesis of free α-amino acids without any protection/deprotection step. This method was also effective for the preparation of a 15N-labeled α-amino acid. 1,2-Diols bearing α,β-unsaturated ester moieties afforded bicyclic α-amino acids through intramolecular [3 + 2] cycloadditions. A preliminary study suggests that the resultant α-amino acids are resolvable by aminoacylases with almost complete selectivity.

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