331810-10-7

Basic information

• Product Name: 31-(trimethylsilylether)rapamycin
• Synonyms: 31-(trimethylsilylether)rapamycin
• CAS NO: 331810-10-7
• Molecular Weight: 986.369
• Mol File: 331810-10-7.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: 31-(trimethylsilylether)rapamycin(CAS DataBase Reference)
• NIST Chemistry Reference: 31-(trimethylsilylether)rapamycin(331810-10-7)
• EPA Substance Registry System: 31-(trimethylsilylether)rapamycin(331810-10-7)

Safety Data

• Hazardous Substances Data: 331810-10-7(Hazardous Substances Data)

Upstream product

• 53123-88-9 sirolimus 
• 331810-13-0 31,42-bis(trimethylsilylether)rapamycin 
• 75-77-4 chloro-trimethyl-silane 

Downstream Products

• 179076-04-1 31-(triethylsilylether)rapamycin 
• 572924-54-0 Ridaforolimus 
• 331810-13-0 31,42-bis(trimethylsilylether)rapamycin 
• 155435-45-3 31,42-bis(triethylsilylether)rapamycin 
• 53123-88-9 sirolimus 
• 143030-02-8 C₄₀-TBS-rap 
• 1217343-53-7 Y₃₁-1 
• 1217343-52-6 Y₈₆ 

Relevant articles and documents

Synthesis and anticancer activity of novel rapamycin C-28 containing triazole moiety compounds

Rapamycin is an mTOR allosteric inhibitor with multiple functions such as immunosuppressive, anticancer, and lifespan prolonging activities. Its C-43 semi-synthetic derivatives temsirolimus and everolimus have been used as mTOR targeting anticancer drugs

Preparation method of everolimus

The invention discloses a preparation method of everolimus. The preparation method comprises the following step of performing deprotection reaction on an everolimus intermediate C. The preparation method of everolimus adopts a manner of regioselective protection of rapamycin 28-hydroxyl, so that the selectivity of a 40-hydroxyl alkylation reaction is improved; side reactions are reduced; a total yield of everolimus calculated from rapamycin can reach above 70%; compared with yields reported in available literatures, the yield is greatly increased; a technical operation procedure is simplified;the product quality is ensured; and the preparation method has better industrial application and popularization prospects.

Intermediate of temsirolimus and preparation method thereof

The invention provides an intermediate of temsirolimus. The intermediate has better selectivity and higher yield when used for preparation of the temsirolimus. The intermediate provided by the invention has a structural formula which is described in the specification.