33216-52-3

Basic information

• Product Name: 3,4,5-Trichloropyridine
• Synonyms: 3,4,5-TRICHLOROPYRIDINE;3,4,5- threechlorine pyridine
• CAS NO: 33216-52-3
• Molecular Formula: C₅H₂Cl₃N
• Molecular Weight: 182.44
• EINECS: -0
• Product Categories: Heterocyclic Series;pharmacetical;Pyridine series;C5Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyridines;Chlorinated heterocyclic series
• Mol File: 33216-52-3.mol

Chemical Properties

• Melting Point: 75-77°C
• Boiling Point: 213-215°C
• Flash Point: 213-215°C
• Appearance: white solid
• Density: 1.539 g/cm³
• Vapor Pressure: 0.29mmHg at 25°C
• Refractive Index: 1.572
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: -0.08±0.10(Predicted)
• BRN: 120542
• CAS DataBase Reference: 3,4,5-Trichloropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4,5-Trichloropyridine(33216-52-3)
• EPA Substance Registry System: 3,4,5-Trichloropyridine(33216-52-3)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 33216-52-3(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
3,4,5-Trichloropyridine is used as a key intermediate in the synthesis of a wide range of organic and pharmaceutical compounds. Its reactivity allows for the formation of various functional groups, making it a versatile building block for the development of new molecules with potential applications in various industries.
Used in Quantitative NMR (qNMR) Studies:
3,4,5-Trichloropyridine is used as a secondary standard in quantitative NMR studies. Its well-defined chemical shifts and stability under NMR conditions make it an ideal reference compound for calibrating NMR instruments and ensuring accurate quantification of other compounds in a sample. This application is particularly important in research and quality control settings, where precise measurements are crucial for understanding chemical structures and properties.

InChI:InChI=1/C5H2Cl3N/c6-3-1-9-2-4(7)5(3)8/h1-2H

Upstream product

• 7647-01-0 hydrogenchloride 
• 26482-55-3 4-(nitroamino)pyridine 
• 110-86-1 pyridine 
• 7782-50-5 chlorine 

Downstream Products

• 22889-78-7 3,5-dichloro-4-aminopyridine 
• 17228-71-6 3,5-dichloro-4-hydroxypyridine 
• 872273-26-2 3,5-dichloro-pyridine-4-sulfonic acid 
• 890664-90-1 4-(3,5-dichloropyridin-4-yloxy)benzenamine 
• 144035-83-6 piclamilast 
• 167888-66-6 4-O-Benzylhydroxylamino-3,5-dichloropyridine hydrochloride 
• 164720-91-6 4-(O-benzylhydroxylamino)-3,5-dichloropyridine 
• 153708-69-1 (3,5-dichloropyridin-4-yl)hydrazine 
• 1224157-80-5 3,5-dichloro-N-cyclohexylpyridin-4-amine 
• 1224157-83-8 3,5-dichloro-N-(4-methoxyphenyl)pyridin-4-amine 
• 1224157-82-7 3,5-dichloro-N-phenylpyridin-4-amine 
• 1224157-81-6 3,5-dichloro-N-(1-phenylethyl)pyridin-4-amine 
• 1247824-86-7 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-N-[4-(3-dimethylamino-propoxy)phenyl]-4-nitrothiophene-2-carboxamide 
• 1247823-27-3 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-N-(4-methoxyphenyl)-4-nitrothiophene-2-carboxamide 

Relevant articles and documents

Lewis Acidic Boranes, Lewis Bases, and Equilibrium Constants: A Reliable Scaffold for a Quantitative Lewis Acidity/Basicity Scale

A quantitative Lewis acidity/basicity scale toward boron-centered Lewis acids has been developed based on a set of 90 experimental equilibrium constants for the reactions of triarylboranes with various O-, N-, S-, and P-centered Lewis bases in dichloromethane at 20 °C. Analysis with the linear free energy relationship log KB=LAB+LBB allows equilibrium constants, KB, to be calculated for any type of borane/Lewis base combination through the sum of two descriptors, one for Lewis acidity (LAB) and one for Lewis basicity (LBB). The resulting Lewis acidity/basicity scale is independent of fixed reference acids/bases and valid for various types of trivalent boron-centered Lewis acids. It is demonstrated that the newly developed Lewis acidity/basicity scale is easily extendable through linear relationships with quantum-chemically calculated or common physical–organic descriptors and known thermodynamic data (ΔH (Formula presented.)). Furthermore, this experimental platform can be utilized for the rational development of borane-catalyzed reactions.