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Cas Database

33695-59-9

33695-59-9

Identification

  • Product Name:2-methoxypropanenitrile

  • CAS Number: 33695-59-9

  • EINECS:

  • Molecular Weight:85.1057

  • Molecular Formula: C4H7NO

  • HS Code:2926909090

  • Mol File:33695-59-9.mol

Synonyms:Methyl isopropyl ether;Isopryl;Ether,isopropyl methyl;2-methoxy-propionitrile;methyl 2-propyl ether;Propanenitrile, 2-methoxy-;O-Methyl-milchsaeure-nitril;isopropyl methyl ether;isopropenyl methyl ether;2-Methoxy-propionitril;Propane,2-methoxy;

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:2-Methoxypropanenitrile
  • Packaging:1g
  • Price:$ 525
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Matrix Scientific
  • Product Description:2-Methoxypropanenitrile
  • Packaging:500mg
  • Price:$ 420
  • Delivery:In stock
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  • Manufacture/Brand:ChemBridge Corporation
  • Product Description:2-methoxypropanenitrile 95%
  • Packaging:1 g
  • Price:$ 46
  • Delivery:In stock
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  • Manufacture/Brand:AK Scientific
  • Product Description:2-Methoxypropanenitrile
  • Packaging:500mg
  • Price:$ 617
  • Delivery:In stock
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Relevant articles and documentsAll total 5 Articles be found

Zhulin,Volchek

, (1977)

Side-chain fragmentation of arylalkanol radical cations. Carbon-carbon and carbon-hydrogen bond cleavage and the role of α- and β-OH groups

Baciocchi, Enrico,Bietti, Massimo,Putignani, Lorenza,Steenken, Steen

, p. 5952 - 5960 (2007/10/03)

A product analysis and kinetic study of the one-electron oxidation of a number of 1-arylpropanols, 1,2-diarylethanols, and some of their methyl ethers by potassium 12-tungstocobaltate(III) (abbreviated as Co(III)W) in aqueous acetic acid was carried out and complemented by pulse radiolysis experiments. The oxidations occur via radical cations which undergo side-chain fragmentation involving the C(α)-H and/or C(α)-C(β) bond. With 1-(4-methoxyphenyl)-2-methoxypropane (1), only deprotonation of the radical cation is observed. In contrast, removing the ring methoxy group leads to exclusive C-C bond cleavage in the radical cation. Replacing the side-chain β-OMe by β-OH, the radical cation undergoes both C-C and C-H bond cleavage, with both pathways being base catalyzed. C-C bond breaking in the radical cation is also enhanced by an α-OH group, as shown by 1-(4-methoxyphenyl)-2,2-dimethyl-1-propanol (7), where this pathway, which is also base catalyzed, is the only one observed. Interestingly, α- and β-OH groups exhibit a very similar efficiency in assisting the C-C bond cleavage route in the radical cations, as is evident from the kinetic and products study of the oxidation of 1-phenyl-2-(4-methoxyphenyl)ethanol (5) and 1-(4-methoxyphenyl)-2-phenylethanol (6) by Co(III)W, and from pulse radiolysis experiments on 5 and 6. C-C bond cleavage is the main reaction for both radical cations which exhibit a very similar rate of fragmentation (k = 2.0 and 3.2 x 104 s-1, respectively). In both fragmentation reactions a small solvent isotope effect, k(H2O)/k(D2O) (1.4 for 5.+ and 1.2 for 6.+) and negative activation entropies are observed. These data suggest that a key role in the assistance by α- or β-OH groups to C-C bond cleavage is played by hydrogen bonding or specific solvation of these groups. The kinetic study of the oxidations promoted by Co(III)W has also shown that when only one group, OH or OMe, is present in the side chain (either on C(α) or C(β)), the fragmentation step or both the electron transfer and fragmentation steps contribute to the overall oxidation rate. However, with an OH group on both carbons of the scissile bond, as in 1-(4-methoxyphenyl)-1,2-propanediol (9), the rate of C-C bond cleavage is so fast that the electron transfer step becomes rate determining.

The Influence of Borate Buffers on the Hydration Rate of Cyanohydrins: Evidence for an Intramolecular Mechanism

Jammot, Jacqueline,Pascal, Robert,Commeyras, Auguste

, p. 157 - 162 (2007/10/02)

The effects of borate buffers on the pseudo first-order rate constants for the hydration of hydroxyacetonitrile (1) have been examined on the pH range 8.6-10.3 at 80 deg C.Kinetic results are compatible with a reaction of the neutral cyanohydrin with borate anion or any other kinetically equivalent mechanism.Cyanohydrin structural effects are consistent with a pathway involving the pre-equilibrium formation of a borate-substrate adduct, followed by a rate-determining intramolecular nucleophilic attack on the nitrile group.Phenylboronate ion has also been shown to act as an efficient catalyst, but it was not possible to detect any influence due to disubstituted borate ions.Thus, it is suggested that a trigonal borate anion actually acts as a nucleophile.

CYANOTRIMETHYLSILANE AS A VERSATILE REAGENT FOR INTRODUCING CYANIDE FUNCTIONALITY

Utimoto, Kiitiro,Wakabayashi, Yukio,Horiie,Takafumi,Inoue, Masaharu,Shishiyama, Yuho,et al.

, p. 967 - 974 (2007/10/02)

Cyanotrimethylsilane adds to some α,β-unsaturated ketones in conjugate manner under the catalytic action of Lewis acids such as triethylaluminium, aluminium chloride, and SnCl2.Hydrolysis of the products gives β-cyano ketones which are identical to the hydrocyanated products of the starting enones.The title silicon reagent reacts with acetals and orthoesters under the catalytic action of SnCl2 or BF3*OEt2 affording 2-alkoxy- and 2,2-dialkoxyalkanenitriles.Application of the reaction to O-protected β-D-ribofuranoses gives selectively β-D-ribofuranosyl cyanide in excellent yield.

Synthetic Methods and Reactions; 114. General Procedure for the Conversion of Acetals and Ketone Acetals into 2-Alkoxyalkanenitriles using Cyanotrimethylsilane

Kirchmeyer, Stephan,Mertens, Alfred,Arvanaghi, Massoud,Olah, George A.

, p. 498 - 500 (2007/10/02)

-

2-ALKOXY AND 2,2-DIALKOXY NITRILES FROM ACETALS AND ORTHOESTERS --- EXCHANGE OF ALKOXY INTO CYANO GROUP BY MEANS OF CYANOTRIMETHYLSILANE

Utimoto, Kiitiro,Wakabayashi, Yukio,Shishiyama, Yuho,Inoue, Masaharu,Nozaki, Hitosi

, p. 4279 - 4280 (2007/10/02)

Title transformation is accomplished by the catalytic action of SnCl2 or BF3*OEt2.Lithio derivative of 2,2-dimethoxyacetonitrile is used as synthetic equivalent of methyl lithioformate.

Process route upstream and downstream products

Process route

1,1-dimethoxyethane
534-15-6

1,1-dimethoxyethane

trimethylsilyl cyanide
7677-24-9

trimethylsilyl cyanide

2-methoxy-propanenitrile
33695-59-9

2-methoxy-propanenitrile

Conditions
Conditions Yield
boron trifluoride diethyl etherate; for 3h; Ambient temperature;
73%
boron trifluoride diethyl etherate; at 0 ℃; for 2h;
73%
zinc(II) iodide; at 25 ℃; for 0.25h;
63%
With boron trifluoride diethyl etherate;
2-methoxy-propionic acid amide
22543-21-1,336111-21-8,336111-20-7

2-methoxy-propionic acid amide

2-methoxy-propanenitrile
33695-59-9

2-methoxy-propanenitrile

Conditions
Conditions Yield
With thionyl chloride; In chloroform; for 2h; Heating;
72%
methyl 1-chloroethyl ether
1538-87-0

methyl 1-chloroethyl ether

2-methoxy-propanenitrile
33695-59-9

2-methoxy-propanenitrile

Conditions
Conditions Yield
methoxyethene
107-25-5,9003-09-2

methoxyethene

hydrogen cyanide
74-90-8

hydrogen cyanide

2-methoxy-propanenitrile
33695-59-9

2-methoxy-propanenitrile

Conditions
Conditions Yield
With pyridine; at 200 ℃;
methyl 1-chloroethyl ether
1538-87-0

methyl 1-chloroethyl ether

2-methoxy-propanenitrile
33695-59-9

2-methoxy-propanenitrile

Conditions
Conditions Yield
With diethyl ether;
methanol
67-56-1

methanol

1-cyanoethyl benzenesulfonate
10531-15-4

1-cyanoethyl benzenesulfonate

2-methoxy-propanenitrile
33695-59-9

2-methoxy-propanenitrile

Conditions
Conditions Yield
With sodium hydroxide;
potassium cyanide
151-50-8

potassium cyanide

acetaldehyde
75-07-0,9002-91-9

acetaldehyde

dimethyl sulfate
77-78-1

dimethyl sulfate

2-methoxy-propanenitrile
33695-59-9

2-methoxy-propanenitrile

Conditions
Conditions Yield
With water;
2-methoxy-propanenitrile
33695-59-9

2-methoxy-propanenitrile

Conditions
Conditions Yield
methyl 1-chloroethyl ether
1538-87-0

methyl 1-chloroethyl ether

copper(I) cyanide
544-92-3

copper(I) cyanide

2-methoxy-propanenitrile
33695-59-9

2-methoxy-propanenitrile

Conditions
Conditions Yield
2-hydroxy-propionitrile
78-97-7

2-hydroxy-propionitrile

2-methoxy-propanenitrile
33695-59-9

2-methoxy-propanenitrile

Conditions
Conditions Yield

Global suppliers and manufacturers

Global( 1) Suppliers
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  • ChemBridge Corporation
  • Business Type:Trading Company
  • Contact Tel:(800) 964-6143
  • Emails:support@chembridge.com
  • Main Products:1
  • Country:United States
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