33884-41-2

Basic information

• Product Name: 3-(ETHOXYMETHYLENE)-2,4-PENTANEDIONE
• Synonyms: AKOS MSC-0742;3-(ETHOXYMETHYLENE)-2,4-PENTANEDIONE;3-(ETHOXYMETHYLENE)ACETYLACETONE;3-ETHOXY METHYLENE PENTANE-2,4-DIONE;3-Ethoxymethylene-2,4-pentanedione, 98+%;3-(Ethoxymethylene)-2,4-pentanedione,97%;3-Ethoxymethylene-2,4-pentandione;3-(EthoxyMethylene)-2,4-pentanedione, 97% 1GR
• CAS NO: 33884-41-2
• Molecular Formula: C₈H₁₂O₃
• Molecular Weight: 156.18
• Mol File: 33884-41-2.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 140-142 °C (16 mmHg)
• Flash Point: 140-142°C/15mm
• Appearance: Clear yellow liquid
• Density: 1.01 g/cm³
• Vapor Pressure: 0.00094mmHg at 25°C
• Refractive Index: 1.483-1.485
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(ETHOXYMETHYLENE)-2,4-PENTANEDIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(ETHOXYMETHYLENE)-2,4-PENTANEDIONE(33884-41-2)
• EPA Substance Registry System: 3-(ETHOXYMETHYLENE)-2,4-PENTANEDIONE(33884-41-2)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 33884-41-2(Hazardous Substances Data)

Usage

Chemical Properties

clear yellow liquid

InChI:InChI=1/C8H12O3/c1-4-11-5-8(6(2)9)7(3)10/h5H,4H2,1-3H3

Upstream product

• 123-54-6 acetylacetone 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 109516-00-9 6-acetyl-5-methyl-1-phenyl-1H-pyrido[2,3-d]pyrimidine-2,4-dione 
• 124135-54-2 6-[1-(2,6-dioxo-3-phenyl-1,2,3,6-tetrahydro-pyrimidin-4-ylimino)-ethyl]-5-methyl-1-phenyl-1H-pyrido[2,3-d]pyrimidine-2,4-dione 
• 55933-85-2 acetyl-5 dimethyl-2,4 pyrimidine 
• 21699-40-1 1-[1-(3,5-bis-trifluoromethyl-phenyl)-5-methyl-1H-pyrazol-4-yl]-ethanone 
• 173678-25-6 6-Acetyl-2-(1,1-dimethylethyl)-7-methylpyrazolo<1,5-a>pyrimidine 
• 130506-84-2 6-acetyl-7-methyl-3-phenylpyrazolo<1,5-a>pyrimidine 
• 71591-87-2 3-(aminomethylene)pentane-2,4-dione 
• 105224-04-2 1-(3-methyl-1H-pyrazol-4-yl)ethanone 
• 165283-95-4 5-acetyl-6-methyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile 
• 5078-58-0 1-(4-fluorophenyl)-4-acetyl-5-methylpyrazole 
• 667866-04-8 1-(1-(4-chlorophenyl)-5-methyl-1H-pyrazol-4-yl)ethan-1-one 
• 112599-50-5 N³,N⁵-bis-(2-acetyl-3-oxo-but-1-enyl)-1-phenyl-1H-[1,2,4]triazole-3,5-diyldiamine 
• 52773-23-6 1-(1,3-dimethyl-1H-pyrazol-4-yl)ethan-1-one 

Relevant articles and documents

Synthesis and properties of water-soluble 2-aminomethylidene derivatives of 1,3-dicarbonyl compounds

A series of [(2-dimethylamino)ethylamino]methylidene-1,3-dicarbonyl compounds was synthesized for the first time starting from the corresponding 2-ethoxymethylidene derivatives and N,N-dimethylethylenediamine. It was shown that further alkylation of aminomethylidene derivatives with methyl iodide occurs regioselectively at the tertiary nitrogen atom. Quaternization products obtained exhibit high corrosion inhibition of mild steel in hydrochloric acid medium.

Development of DHQ-based chemical biology probe to profile cellular targets for HBV

Chronic hepatitis B virus (HBV) infection has been a serious public health burden worldwide. Current anti-HBV therapies could not eliminate HBV ultimately. Considering the characteristics of HBV, it is impossible to be entirely cured based on current therapies. Therefore, it is urgently needed to develop novel therapeutic agents with new mechanism of action. The dihydroquinolizinone (DHQ) derivatives exhibited potent anti-HBV activity by decreasing HBV DNA and HBsAg level in an obscure mechanism of action. In this study, we have optimized the DHQ scaffold, developed the photoaffinity probe, with which to identify potential binding proteins.

PYRIDINONE- AND PYRIDAZINONE-BASED COMPOUNDS AND MEDICAL USES THEREOF

The various examples presented herein are directed to compounds of the formula A-L1-Het1-L2-Cy1 or a pharmaceutical acceptable salt, polymorph, prodrug, solvate or clathrate thereof, wherein: A is cycloalkyl, aryl, arylalkyl or heterocyclyl; Het1 is heterocyclyl containing at least two heteroatoms; Cy1 is a heterocyclyl; L1 is a bond, alkyl, alkenyl or alkynyl linker; L2 is an acyl or alkyl linker; and A and Cy1 are different. The compounds are useful in the treatment of fibrotic diseases, abnormal vascular leak and pathological angiogenesis.

SUBSTITUTED PYRIMIDINE COMPOUNDS AS mPGES-1 INHIBITORS

The present disclosure is directed to substituted pyrimidine compounds of formula (I), and pharmaceutically acceptable salts thereof, as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and a