1522-25-4Relevant academic research and scientific papers
Significant enhancement in radical-scavenging activity of curcuminoids conferred by acetoxy substituent at the central methylene carbon
Kim, Mi Kyoung,Jeong, Wooseong,Kang, Jihoon,Chong, Youhoon
experimental part, p. 3793 - 3800 (2011/08/06)
For a compound to be a radical-trapping antioxidant, the antioxidant-derived radical must be sufficiently inert to molecular oxygen as this would generate harmful chain-propagating peroxyl radicals. Curcumin has a unique structure with phenolic hydroxyl g
SUBSTITUENT EFFECTS IN KETO-ENOL TAUTOMERISM. PART 3. INFLUENCE OF SUBSTITUTION ON THE EQUILIBRIUM COMPOSITION OF β-DICARBONYL COMPOUNDS.
Bassetti, M.,Cerichelli, G.,Floris, B.
, p. 2997 - 3004 (2007/10/02)
The enol content and equilibrium free energies for the keto-enol tautomerism have been determined for a series of 1,3-diketones, at 40 deg C, in deuterochloroform and dimethylsulfoxide-d6 (DMSO), by (1)H n.m.r..Compounds containing methyl, phenyl, t-butyl, 2-thienyl, trifluoromethyl and ethoxy groups have been examined.The equilibrium free energies in DMSO are characterized by a linear additivity effect, and substituent parameters, representing the variation produced by the substituent, have been calculated.Equilibrium enthalpy and entropy have been obtained in the range of temperature 20-60 deg C.A correlation between enolic 1J-CH= coupling constants and equilibrium free energies in DMSO is discussed in terms of substituent effects on the energy of the enol.
