34405-42-0

Basic information

• Product Name: 2-AMINO-2-METHYL-1-PHENYL-PROPAN-1-OL
• Synonyms: 2-AMINO-2-METHYL-1-PHENYL-PROPAN-1-OL;USAF CS-8;α-(1-Amino-1-methylethyl)benzenemethanol
• CAS NO: 34405-42-0
• Molecular Formula: C₁₀H₁₅NO
• Molecular Weight: 165.2322
• Mol File: 34405-42-0.mol

Chemical Properties

• Melting Point: 100-101 °C
• Boiling Point: 295°Cat760mmHg
• Flash Point: 132.2°C
• Appearance: /
• Density: 1.05g/cm³
• Vapor Pressure: 0.000709mmHg at 25°C
• Refractive Index: 1.55
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 12.09±0.50(Predicted)
• CAS DataBase Reference: 2-AMINO-2-METHYL-1-PHENYL-PROPAN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-2-METHYL-1-PHENYL-PROPAN-1-OL(34405-42-0)
• EPA Substance Registry System: 2-AMINO-2-METHYL-1-PHENYL-PROPAN-1-OL(34405-42-0)

Safety Data

• Hazardous Substances Data: 34405-42-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
2-AMINO-2-METHYL-1-PHENYL-PROPAN-1-OL is used as a research compound for its role in inducing DNA polymerase β-dependent base excision repair in response to oxidative stress in the liver. This application is significant for understanding the mechanisms of cellular response to oxidative damage and potentially developing treatments for related conditions.
Used in Toxicology Studies:
As a known carcinogen, 2-AMINO-2-METHYL-1-PHENYL-PROPAN-1-OL is utilized in toxicology studies to investigate the effects of carcinogens on biological systems. This helps in the development of preventive measures and treatments for cancer and other diseases associated with oxidative stress.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2-AMINO-2-METHYL-1-PHENYL-PROPAN-1-OL may serve as a starting material or intermediate for the production of other pharmaceuticals or chemical compounds with various applications.

InChI:InChI=1/C10H15NO/c1-10(2,11)9(12)8-6-4-3-5-7-8/h3-7,9,12H,11H2,1-2H3

Upstream product

• 68385-34-2 N-(2-hydroxy-1,1-dimethyl-2-phenylethyl)hydroxylamine 
• 33687-74-0 1-phenyl-2-methyl-2-nitropropanol 
• 91994-63-7 2,2,2-Trifluoro-N-(2-hydroxy-1,1-dimethyl-2-phenyl-ethyl)-acetamide 
• 100-52-7 benzaldehyde 
• 91994-55-7 2,2,2-trifluoro-N-(2-methyl-1-oxo-1-phenylpropaN-2-yl)acetamide 
• 78485-90-2 1,1-Dimethyl-2-phenyl-2-trimethylsilanyloxy-ethylamine 

Downstream Products

• 343225-51-4 2-benzylidenamino-2-methyl-1-phenyl-propan-1-ol 
• 122-09-8 Phentermin 
• 343228-90-0 2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-2-methyl-1-phenyl-propan-1-ol 
• 343817-71-0 2-Methyl-2-{[1-naphthalen-1-yl-meth-(E)-ylidene]-amino}-1-phenyl-propan-1-ol 
• 343814-98-2 N-(4-{[(E)-2-Hydroxy-1,1-dimethyl-2-phenyl-ethylimino]-methyl}-phenyl)-acetamide 
• 343817-67-4 2-Methyl-2-{[1-naphthalen-2-yl-meth-(E)-ylidene]-amino}-1-phenyl-propan-1-ol 
• 343235-27-8 2-{[1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-amino}-2-methyl-1-phenyl-propan-1-ol 
• 77740-66-0 α-<1-methyl-1-<(phenylmethyl)amino>ethyl>benzenemethanol 
• 77740-51-3 1,2,3,4-tetrahydro-3,3-dimethyl-4-phenyl-7-isoquinolinol 
• 77740-54-6 1,2,3,4-tetrahydro-3,3-dimethyl-4-phenyl-6-isoquinolinamine 
• 77740-67-1 α-<1-<<(3-hydroxyphenyl)methyl>amino>-1-methylethyl>benzenemethanol 
• 77740-69-3 α-<1-<<(4-chlorophenyl)methyl>amino>-1-methylethyl>benzenemethanol 
• 77740-80-8 α-<1-<<(2-aminophenyl)methyl>amino>-1-methylethyl>benzenemethanol 
• 77740-63-7 1,2,3,4-tetrahydro-2,2-dimethyl-1-phenylbenzisoquinoline 

Relevant articles and documents

Benzenesulfonyl-Asymmetric Ureas and Medical Uses Thereof

Benzenesulfonyl-asymmetric ureas are provided for the treatment of conditions modulated by the ghrelin receptor.

INDOZALYL SULPHONAMIDE DERIVATIVES USEFUL AS GLUCOCORTICOID MODULATORS

Compounds of formula (I) or a pharmaceutically acceptable salt thereof; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating the glucocorticoid receptor in a warm blooded animal).

Friedel-Crafts Acylation with N-(Trifluoroacetyl)-α-amino Acid Chlorides. Application to the Preparation of β-Arylalkylamines and 3-Substituted 1,2,3,4-Tetrahydroisoquinolines

Several N-(trifluoroacetyl)-α-amino acid chlorides have been reacted with benzene, anisole, and veratrole in the presence of AlCl3 or SnCl4 to produce the corresponding aromatic ketones in fair to high yields.The products are reductible under neutral or acidic conditions to the corresponding N-(trifluoroacetyl)-β-hydroxy-β-arylakylamines or N-(trifluoroacetyl)-β-arylalkylamines.The latter can be readily detrifluoroacetylated by mild basic hydrolysis and thence converted to the corresponding 3-substituted 1,2,3,4-tetrahydroisoquinolines by condensation with formaldehyde.

Electrochemical Reduction of Tertiary Nitroalkanes to Amines

Electrochemical reduction of tertiary nitroalkanes, 2-substituted-1,1-dimethyl-1-nitroethanes (1), was investigated in aqueous buffer solutions.In polarography, 1 with a phenyl group and/or a hydroxyl group at the 2-position showed an ill-defined wave in the weakly acidic and neutral pH region at relatively high negative potentials, in addition to a well-defined wave arising from the reduction of 1 to the corresponding hydroxylamine (2).Controlled potential electrolysis of 1 at the potential of the former wave gave the 1,1-dimethylethylamines (3) as well as the hydroxylamines 2.The amines 3 are formed exclusively from 2, probably via the O-protonated form.It is suggested that a phenyl group at the 2-position facilitates the reduction of 2 to 3 by enhancing the adsorption of 2 at the mercury cathode and that a hydroxyl group, while it interferes with the adsorption, assists the reduction by intramolecular hydrogen-bonding to stabilize the O-protonated form of 2.Keywords - tertiary nitroalkane; alkylhydroxylamine; electrochemical reduction; polarography; controlled potential electrolysis.

Improved Nitroaldol Reactions and Reductive Routes to Vicinal Aminoalcohols

Regioselective and flexible procedures are described for the preparation of a variety of protected vicinal nitroalcohols 1, 3, and 5 (see Scheme 5), as is an efficient method for their reduction to the corresponding vicinal aminoalcohols 2, 4 and 6.