351-78-0

Basic information

• Product Name: β-fluorostyrene
• Synonyms: β-fluorostyrene
• CAS NO: 351-78-0
• Molecular Weight: 122.142
• Mol File: 351-78-0.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: β-fluorostyrene(CAS DataBase Reference)
• NIST Chemistry Reference: β-fluorostyrene(351-78-0)
• EPA Substance Registry System: β-fluorostyrene(351-78-0)

Safety Data

• Hazardous Substances Data: 351-78-0(Hazardous Substances Data)

Upstream product

• 591-50-4 iodobenzene 
• 96385-23-8 P-(monofluoromethyl)triphenylphosphonium tetrafluoroborate 
• 68-12-2 N,N-dimethyl-formamide 
• 201230-82-2 carbon monoxide 
• 118559-15-2 (E)-β-bromo-β-fluorostyrene 
• 71-36-3 butan-1-ol 
• 5396-91-8 1,5-diphenyl-3-pentanone 
• 83947-56-2 4,4,5,5-tetramethyl-2-((E)-styryl)-[1,3,2]dioxaborolane 
• 350-90-3 (Z/E)-2-fluoro-3-phenylprop-2-enoic acid 
• 78782-27-1 4,4,5,5-tetramethyl-2-styryl-[1,3,2]dioxaborolane 
• 321-74-4 2-bromo-2-fluoro-1-phenyl-ethanol 
• 321-76-6 2-chloro-2-fluoro-1-phenylethanol 
• 100-52-7 benzaldehyde 
• 2498-46-6 2-phenylacetamidine hydrochloride 

Downstream Products

• 637-50-3 1-phenylpropene 
• 1817-51-2 1-phenyl-1-hexyn-3-ol 
• 1215017-02-9 C₂₀H₁₇F₂NO₄S₂ 
• 917381-61-4 5-(trifluoromethyl)-[1,1′-biphenyl]-2-amine 
• 748785-01-5 N-[(5-trifluoromethyl)biphenyl-2-yl]benzamide 
• 122-78-1 phenylacetaldehyde 

Relevant articles and documents

Olefination via Cu-Mediated Dehydroacylation of Unstrained Ketones

The dehydroacylation of ketones to olefins is realized under mild conditions, which exhibits a unique reaction pathway involving aromatization-driven C-C cleavage to remove the acyl moiety, followed by Cu-mediated oxidative elimination to form an alkene between the α and β carbons. The newly adopted N′-methylpicolinohydrazonamide (MPHA) reagent is key to enable efficient cleavage of ketone C-C bonds at room temperature. Diverse alkyl- and aryl-substituted olefins, dienes, and special alkenes are generated with broad functional group tolerance. Strategic applications of this method are also demonstrated.

FLUORINATION METHOD

The present invention relates to a process for producing an organic compound comprising an 18F atom. The compounds comprising an 18F can be useful as PET ligands for use in diagnostics and/or scanning. The process of the invention comprises treating an organoboron compound, which organoboron compound comprises a boron atom bonded to an sp2 hybridised carbon atom, with (i) 18F – and (ii) a copper compound. The invention also provides the use of an organoboron compound, which organoboron compound comprises a boron atom bonded to an sp2 hybridised carbon atom, in a process for producing an organic compound comprising an 18F atom, which process comprises treating the organoboron compound with (i) 18F – and (ii) a copper compound. The invention also provides a compound of formula (XXXVII): wherein: each PGA is independently H or an alcohol protecting group; PGB is H or a carboxylic acid protecting group; each PGC is independently an amine protecting group; Z is a group selected from a boronic ester group, a boronic acid group, a borate group, and a trifluoroborate group; and a is an integer from 0 to 4.

FLUORINATION OF ORGANIC COMPOUNDS

Methods for fluorinating organic compounds are described herein.