3886-80-4

Basic information

• Product Name: N-DODECYL-ACETAMIDE
• Synonyms: N-DODECYL-ACETAMIDE
• CAS NO: 3886-80-4
• Molecular Formula: C₁₄H₂₉NO
• Molecular Weight: 227.39
• Mol File: 3886-80-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 51 °C
• Boiling Point: 369.11°C (rough estimate)
• Flash Point: 185.1°C
• Appearance: /
• Density: 0.9035 (rough estimate)
• Vapor Pressure: 0.000865mmHg at 25°C
• Refractive Index: 1.4640 (estimate)
• Storage Temp.: Room Temperature, under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 16.51±0.46(Predicted)
• CAS DataBase Reference: N-DODECYL-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-DODECYL-ACETAMIDE(3886-80-4)
• EPA Substance Registry System: N-DODECYL-ACETAMIDE(3886-80-4)

Safety Data

• Hazardous Substances Data: 3886-80-4(Hazardous Substances Data)

Usage

General Description

N-dodecyl-acetamide is a long-chain fatty amide compound with the chemical formula C14H29NO. It is commonly used as an emollient and conditioning agent in various cosmetic and personal care products such as lotions, creams, and shampoos. N-dodecyl-acetamide acts as a surfactant, helping to reduce the surface tension of liquids and allowing them to spread more easily. It also has emulsifying properties, helping to blend oil and water-based ingredients in personal care formulations. Additionally, N-dodecyl-acetamide has moisturizing and smoothing properties, making it a popular ingredient in skincare products.

InChI:InChI=1/C14H29NO/c1-3-4-5-6-7-8-9-10-11-12-13-15-14(2)16/h3-13H2,1-2H3,(H,15,16)

Upstream product

• 17448-65-6 dodecylamine propionate 
• 830-03-5 4-nitrophenol acetate 
• 112-53-8 1-dodecyl alcohol 
• 98-88-4 benzoyl chloride 
• 75-05-8 acetonitrile 
• 124-22-1 n-Dodecylamine 
• 13053-88-8 2-acetylaminopyrimidine 
• 122-79-2 Phenyl acetate 
• 13031-41-9 4-cyanophenyl acetate 
• 1200-06-2 4-methoxyphenyl acetate 
• 140-39-6 1-acetoxy-4-methylbenzene 
• 1927-95-3 4-bromophenyl acetate 

Downstream Products

• 143-07-7 lauric acid 
• 112-37-8 undecylenic acid 
• 124-22-1 n-Dodecylamine 

Relevant articles and documents

Systematic Evaluation of Sulfoxides as Catalysts in Nucleophilic Substitutions of Alcohols

Herein, a method for the nucleophilic substitution (SN) of benzyl alcohols yielding chloro alkanes is introduced that relies on aromatic sulfoxides as Lewis base catalysts (down to 1.5 mol-%) and benzoyl chloride (BzCl) as reagent. A systematic screening of various sulfoxides and other sulfinyl containing Lewis bases afforded (2-methoxyphenyl)methyl sulfoxide as optimal catalyst. In contrast to reported formamide catalysts, sulfoxides also enable the application of plain acetyl chloride (AcCl) as reagent. In addition, it was demonstrated that weakly electrophilic carboxylic acid chlorides like BzCl promote Pummerer rearrangement of sulfoxides already at room temperature. This side-reaction also provided the explanation, why sulfoxide catalyzed SN-reactions of alcohols do not allow the effective production of aliphatic and electron deficient chloro alkanes. Comparison experiments provided further insight into the reaction mechanism.

Pyridine-derived heterocycles as potential photoacylating reagents

We prepared several pyridine-derived heterocycles and investigated their photoacylating properties. Among representatives of 4 families of compounds (1-acetyl-7-azaindole, 1-acetyl-7-azaindoline, 2-acetamindpyridine and 2-amidopyrimidines), the 2-aminopyrimidine derivatives were the most promising candidates. Photoacylation of dodecylamine yields up to 47% were obtained, upon irradiation with UV light at 254 nm.