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5-METHOXYPYRAZINE-2-CARBOXYLIC ACID, a member of the pyrazine carboxylic acid family, is a derivative of pyrazine. It is a white to off-white powder that is sparingly soluble in water. Known for its earthy, nutty, and green aroma, this chemical compound is utilized in various applications, including the flavor and fragrance industry, pharmaceuticals, and agrochemicals. Additionally, it has been studied for its potential medicinal properties, such as antioxidant and anti-inflammatory effects.

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  • 40155-42-8 Structure
  • Basic information

    1. Product Name: 5-METHOXYPYRAZINE-2-CARBOXYLIC ACID
    2. Synonyms: 5-METHOXYPYRAZINE-2-CARBOXYLIC ACID;2-Carboxy-5-methoxypyrazine, 2-Carboxy-5-methoxy-1,4-diazine;5-Methoxy-pyrazinecarboxylic acid;2-Pyrazinecarboxylicacid, 5-Methoxy-;5-Methoxypyrazine-2-carboxylic;Pyrazinecarboxylic acid, 5-methoxy-
    3. CAS NO:40155-42-8
    4. Molecular Formula: C6H6N2O3
    5. Molecular Weight: 154.12
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 40155-42-8.mol
  • Chemical Properties

    1. Melting Point: 197.5-199.5℃
    2. Boiling Point: 296.8 °C at 760 mmHg
    3. Flash Point: 133.3 °C
    4. Appearance: /Solid
    5. Density: 1.371 g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. PKA: 3.18±0.10(Predicted)
    10. CAS DataBase Reference: 5-METHOXYPYRAZINE-2-CARBOXYLIC ACID(CAS DataBase Reference)
    11. NIST Chemistry Reference: 5-METHOXYPYRAZINE-2-CARBOXYLIC ACID(40155-42-8)
    12. EPA Substance Registry System: 5-METHOXYPYRAZINE-2-CARBOXYLIC ACID(40155-42-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 40155-42-8(Hazardous Substances Data)

40155-42-8 Usage

Uses

Used in Flavor and Fragrance Industry:
5-METHOXYPYRAZINE-2-CARBOXYLIC ACID is used as a flavor or fragrance ingredient for its characteristic earthy, nutty, and green aroma, enhancing the sensory experience of various products.
Used in Pharmaceutical Industry:
5-METHOXYPYRAZINE-2-CARBOXYLIC ACID is used as a building block or intermediate in the production of pharmaceuticals, contributing to the development of new drugs and therapies.
Used in Agrochemical Industry:
5-METHOXYPYRAZINE-2-CARBOXYLIC ACID is used in the formulation of agrochemicals, potentially enhancing crop protection and yield.
Used in Medicinal Research:
5-METHOXYPYRAZINE-2-CARBOXYLIC ACID is used as a subject of study in medicinal research for its potential antioxidant and anti-inflammatory properties, indicating its possible use in the development of treatments for various diseases and conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 40155-42-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,1,5 and 5 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 40155-42:
(7*4)+(6*0)+(5*1)+(4*5)+(3*5)+(2*4)+(1*2)=78
78 % 10 = 8
So 40155-42-8 is a valid CAS Registry Number.

40155-42-8 Well-known Company Product Price

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  • Alfa Aesar

  • (H66826)  5-Methoxypyrazine-2-carboxylic acid, 98%   

  • 40155-42-8

  • 250mg

  • 1400.0CNY

  • Detail
  • Alfa Aesar

  • (H66826)  5-Methoxypyrazine-2-carboxylic acid, 98%   

  • 40155-42-8

  • 1g

  • 4200.0CNY

  • Detail

40155-42-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-Methoxypyrazine-2-Carboxylic Acid

1.2 Other means of identification

Product number -
Other names 5-Methoxypyrazine-2-carboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:40155-42-8 SDS

40155-42-8Downstream Products

40155-42-8Relevant articles and documents

SELECTIVE OCTAHYDRO-CYCLOPENTA[C] PYRROLE NEGATIVE MODULATORS OF NR2B

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, (2015/04/15)

Compounds that selectively negatively modulate NMDA receptors containing an NR1/NR2B subunit, pharmaceutical compositions comprising the compounds, and methods of treating a disease using the compounds are disclosed. Such diseases include, without limitation, neurological dysfunction such as Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, multiple sclerosis, and seizure disorders; emotional disorders; depression; bipolar disorder; obsessive-compulsive disorder; and other anxiety disorders.

SYNTHESIS OF BACE1 INHIBITORS

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Page/Page column 17, (2014/11/13)

The present invention provides a one step carbonylation of a compound of formula II in the presence of water to afford a compound of formula (I), useful in processes to manufacture BACE inhibitors.

FUSED AMINODIHYDROTHIAZINE DERIVATIVES

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Page/Page column, (2014/07/08)

The present invention relates to a fused aminodihydrothiazine derivative of formula (I): wherein X is hydrogen or fluorine; R is monofluoromethyl or difluoromethyl; and pharmaceutically acceptable salts thereof; which compound has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ and typified by Alzheimer-type dementia.

FUSED AMINODIHYDROTHIAZINE DERIVATIVES

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Page/Page column 34, (2012/07/31)

The present invention relates to a fused aminodihydrothiazine derivative of formula (I): wherein X is hydrogen or fluorine;A is CH or N;Y is methyl, ethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, difluoroethyl, methoxy, ethoxy, methoxymethyl or —C≡N; and pharmaceutically acceptable salts thereof; which compound has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ and typified by Alzheimer-type dementia.

FUSED AMINODIHYDROTHIAZINE DERIVATIVES USEFUL AS BACE INHIBITORS

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Page/Page column 67, (2012/08/07)

The present invention relates to a fused aminodihydrothiazine derivative of formula (I): wherein X is hydrogen or fluorine; A is CH or N; Y is methyl, ethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, difluoroethyl, methoxy, ethoxy, methoxymethyl or -C≡N; and pharmaceutically acceptable salts thereof; which compound has an Αβ production inhibitory effect or a BACEl inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Αβ and typified by Alzheimer-type dementia.

FUSED AMINODIHYDROTHIAZINE DERIVATIVES

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Page/Page column 86-87, (2012/08/07)

The present invention relates to a fused aminodihydrothiazine derivative of formula (I): wherein X is hydrogen or fluorine; R is monofluoromethyl or difluoromethyl; and pharmaceutically acceptable salts thereof; which compound has an Αβ production inhibit

NEW COMPOUNDS 806

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Page/Page column 157-158, (2008/12/08)

The present invention relates to new compounds of formula (I) and to pharmaceutical composition containing said compounds and to the use of said compounds in therapy. The present invention further relates to processes for the preparation of said compounds and to new intermediates useful in the preparation thereof.

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