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403-43-0

403-43-0

Identification

Synonyms:4-Fluorobenzoylchloride;Benzoyl chloride, p-fluoro-;p-Fluorobenzoic acid chloride;p-Fluorobenzoyl chloride;

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Safety information and MSDS view more

  • Pictogram(s):CorrosiveC

  • Hazard Codes:C

  • Signal Word:Danger

  • Hazard Statement:H314 Causes severe skin burns and eye damage

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

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  • Manufacture/Brand:TRC
  • Product Description:4-Fluorobenzoyl chloride
  • Packaging:50g
  • Price:$ 375
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:4-Fluorobenzoyl Chloride >97.0%(T)
  • Packaging:500g
  • Price:$ 215
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  • Manufacture/Brand:TCI Chemical
  • Product Description:4-Fluorobenzoyl Chloride >97.0%(T)
  • Packaging:100g
  • Price:$ 159
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  • Manufacture/Brand:TCI Chemical
  • Product Description:4-Fluorobenzoyl Chloride >97.0%(T)
  • Packaging:25g
  • Price:$ 40
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:4-Fluorobenzoyl chloride 98%
  • Packaging:250 g
  • Price:$ 95
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:4-Fluorobenzoyl chloride 98%
  • Packaging:100 g
  • Price:$ 55
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:4-Fluorobenzoyl chloride 98%
  • Packaging:25 g
  • Price:$ 30
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:4-Fluorobenzoyl chloride 98%
  • Packaging:1 kg
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:4-Fluorobenzoyl chloride 98%
  • Packaging:100g
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:4-Fluorobenzoyl chloride 98%
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Relevant articles and documentsAll total 144 Articles be found

Branched-arm macromolecule liquid crystals-containing fluorine and isosorbide-structure and properties

He, Xiao-Zhi,Zhang, Fang-Di,Jia, Ying,Meng, Fan-Bao,Jia, Ying-Gang

, p. 96 - 103 (2015)

A new series of cholesteric fluorated branched-arm liquid crystals (CHFBALCs) compound (MFA1-MFA4), with isosorbide as chiral core, was synthesized. Four precursors of branched-arm FA1-FA4 were obtained firstly

Microwave-assisted synthesis and in vitro antibacterial activity of novel steroidal 1,2,4-triazole Schiff base derivatives

Wang, Xiaohong,Liu, Xingli,Jiang, Yujia,Zhao, Zhigang

, p. 300 - 303 (2014)

A series of novel Schiff bases containing both a 1,2,4-triazole and deoxycholic acid skeleton have been synthesised in excellent yields and in high purity by means of microwave irradiation. The structures of the target compounds were characterised by MS, IR and NMR as well as elemental analysis. All the products were evaluated for their in vitro antibacterial activities against Gram positive (Staphylococcus aureus and Bacillus subtilis) and Gram negative bacteria (Pseudomonas seruginosa and Escherichia coli). Four of the compounds displayed varying levels of antibacterial activity against P. aeruginosa and S. aureus, but none of the compounds showed any activity against E. coli and B. subtilis.

Synthesis and Characterization of Two Chiral Pyrrolyl α-Nitronyl Nitroxide Radicals and Determination of their Cytotoxicity and Radioprotective Properties in C6 Cells and Mice under Ionizing Radiation

Tian, Min,Lan, Ting,Gao, Min,Li, Bo,Zhang, Gai,Wang, Hai-Bo

, p. 492 - 500 (2019)

In this study, two chiral nitronyl nitroxyl radicals, L1 and D1, were synthesized and evaluated for their potential radioprotective properties in vitro and in vivo. We synthesized the new stable nitronyl nitroxide radicals, L1 and D1, according to Ullman'

PCl3-mediated transesterification and aminolysis of tert-butyl esters via acid chloride formation

Wu, Xiaofang,Zhou, Lei,Li, Fangshao,Xiao, Jing

, p. 491 - 497 (2021/01/20)

A PCl3-mediated conversion of tert-butyl esters into esters and amides in one-pot under air is developed. This novel protocol is highlighted by the synthesis of skeletons of bioactive molecules and gram-scale reactions. Mechanistic studies revealed that this transformation involves the formation of an acid chloride in situ, which is followed by reactions with alcohols or amines to afford the desired products.

Photochemical Activation of Aromatic Aldehydes: Synthesis of Amides, Hydroxamic Acids and Esters

Nikitas, Nikolaos F.,Apostolopoulou, Mary K.,Skolia, Elpida,Tsoukaki, Anna,Kokotos, Christoforos G.

supporting information, p. 7915 - 7922 (2021/05/03)

A cheap, facile and metal-free photochemical protocol for the activation of aromatic aldehydes has been developed. Utilizing thioxanthen-9-one as the photocatalyst and cheap household lamps as the light source, a variety of aromatic aldehydes have been activated and subsequently converted in a one-pot reaction into amides, hydroxamic acids and esters in good to high yields. The applicability of this method was highlighted in the synthesis of Moclobemide, a drug against depression and social anxiety. Extended and detailed mechanistic studies have been conducted, in order to determine a plausible mechanism for the reaction.

4,4 ’ - Difluorobenzophenone and preparation method and application thereof

-

, (2021/11/21)

The 4, 4 ’ difluorobenzophenone and the preparation method thereof comprise: mixing a molecular sieve and hydrogen peroxide and with fluorobenzaldehyde to form a mixed solution, oxidizing fluorobenzaldehyde into p-fluorobenzoic acid, wherein the molecular sieve is a catalyst. Hydrochloric acid and zinc chloride are added to the mixed solution to generate p-fluorobenzoyl chloride under the condition that the molecular sieve is used as a catalyst. Fluorobenzene was added to the mixed solution containing the p-fluorobenzoyl chloride to obtain the 4, 4 ’ - difluorobenzophenone. Thus, the synthetic method has the following advantages: 4, the yield of 4 ’ - difluorobenzophenone is not lower 98%, the purity is not lower than 99.999%, and the purity makes it available for preparation of medical grade polyether ether ketone. Reaction conditions are easy to control, and the risk of explosion is reduced to a certain extent.

Remarkably Efficient Iridium Catalysts for Directed C(sp2)-H and C(sp3)-H Borylation of Diverse Classes of Substrates

Chattopadhyay, Buddhadeb,Hassan, Mirja Md Mahamudul,Hoque, Md Emdadul

supporting information, p. 5022 - 5037 (2021/05/04)

Here we describe the discovery of a new class of C-H borylation catalysts and their use for regioselective C-H borylation of aromatic, heteroaromatic, and aliphatic systems. The new catalysts have Ir-C(thienyl) or Ir-C(furyl) anionic ligands instead of the diamine-type neutral chelating ligands used in the standard C-H borylation conditions. It is reported that the employment of these newly discovered catalysts show excellent reactivity and ortho-selectivity for diverse classes of aromatic substrates with high isolated yields. Moreover, the catalysts proved to be efficient for a wide number of aliphatic substrates for selective C(sp3)-H bond borylations. Heterocyclic molecules are selectively borylated using the inherently elevated reactivity of the C-H bonds. A number of late-stage C-H functionalization have been described using the same catalysts. Furthermore, we show that one of the catalysts could be used even in open air for the C(sp2)-H and C(sp3)-H borylations enabling the method more general. Preliminary mechanistic studies suggest that the active catalytic intermediate is the Ir(bis)boryl complex, and the attached ligand acts as bidentate ligand. Collectively, this study underlines the discovery of new class of C-H borylation catalysts that should find wide application in the context of C-H functionalization chemistry.

Photo-on-Demand Synthesis of Vilsmeier Reagents with Chloroform and Their Applications to One-Pot Organic Syntheses

Liang, Fengying,Eda, Kazuo,Okazoe, Takashi,Wada, Akihiro,Mori, Nobuaki,Konishi, Katsuhiko,Tsuda, Akihiko

, p. 6504 - 6517 (2021/05/06)

The Vilsmeier reagent (VR), first reported a century ago, is a versatile reagent in a variety of organic reactions. It is used extensively in formylation reactions. However, the synthesis of VR generally requires highly toxic and corrosive reagents such as POCl3, SOCl2, or COCl2. In this study, we found that VR is readily obtained from a CHCl3 solution containing N,N-dimethylformamide or N,N-dimethylacetamide upon photo-irradiation under O2 bubbling. The corresponding Vilsmeier reagents were obtained in high yields with the generation of gaseous HCl and CO2 as byproducts to allow their isolations as crystalline solid products amenable to analysis by X-ray crystallography. With the advantage of using CHCl3, which bifunctionally serves as a reactant and a solvent, this photo-on-demand VR synthesis is available for one-pot syntheses of aldehydes, acid chlorides, formates, ketones, esters, and amides.

Process route upstream and downstream products

Process route

4-fluoro-1-iodobenzene
352-34-1

4-fluoro-1-iodobenzene

4-nitro-benzoyl chloride
122-04-3

4-nitro-benzoyl chloride

p-nitrobenzene iodide
636-98-6

p-nitrobenzene iodide

4-fluorobenzoyl chloride
403-43-0

4-fluorobenzoyl chloride

Conditions
Conditions Yield
With (Xantphos)Pd(4-C6H4NO2)(I); In benzene; at 90 ℃; for 20h; Sealed tube; Inert atmosphere;
91%
1-(4-Fluoro-benzoyl)-3-methyl-3H-imidazol-1-ium; chloride
93342-79-1

1-(4-Fluoro-benzoyl)-3-methyl-3H-imidazol-1-ium; chloride

1-methyl-1H-imidazole
616-47-7

1-methyl-1H-imidazole

4-fluorobenzoyl chloride
403-43-0

4-fluorobenzoyl chloride

Conditions
Conditions Yield
In dichloromethane; at 25 ℃; Rate constant; Equilibrium constant;
tert-butyl 4-fluorobenzoate
58656-98-7

tert-butyl 4-fluorobenzoate

4-fluorobenzoyl chloride
403-43-0

4-fluorobenzoyl chloride

Conditions
Conditions Yield
With phosphorus trichloride; In acetonitrile; at 80 ℃; for 3h; Time; Schlenk technique;
91%
With thionyl chloride; water; at 23 ℃; for 16h; Sealed tube;
With phosphorus trichloride; In acetonitrile; at 80 ℃; for 3h; Schlenk technique; Sealed tube;
1-(4-fluorophenyl)ethanone
403-42-9

1-(4-fluorophenyl)ethanone

4-fluorobenzoyl chloride
403-43-0

4-fluorobenzoyl chloride

Conditions
Conditions Yield
1-(4-fluorophenyl)ethanone; With pyridine; disulfur dichloride; In chlorobenzene; at 20 ℃; for 2h;
With sulfuryl dichloride; In chlorobenzene; at 20 - 132 ℃; for 15.5h;
83%
With pyridine; disulfur dichloride; at 137 ℃; for 20h;
81 %Spectr.
4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

4-fluorobenzoyl chloride
403-43-0

4-fluorobenzoyl chloride

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: aqueous KOH
2: PCl5
With potassium hydroxide; phosphorus pentachloride;
With azobisisobutyronitrile; chlorine;
With trichloroisocyanuric acid; In dichloromethane; at 20 ℃; for 120h; Inert atmosphere;
With tert.-butylhydroperoxide; N-chloro-succinimide; tris(2,2'-bipyridyl)ruthenium dichloride; In acetonitrile; at 20 ℃; for 24h; Sealed tube; Irradiation;
With trichloroisocyanuric acid; In dichloromethane; at 20 ℃; Inert atmosphere;
With trichloroisocyanuric acid; In dichloromethane; at 20 ℃; Inert atmosphere;
With trichloroisocyanuric acid; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere; Irradiation;
Multi-step reaction with 2 steps
1: acetic acid; chromium(VI) oxide / 1.5 h / 70 °C
2: thionyl chloride / tetrachloromethane; N,N-dimethyl-formamide / 5 h / Reflux
With chromium(VI) oxide; thionyl chloride; acetic acid; In tetrachloromethane; N,N-dimethyl-formamide; 2: |Friedel-Crafts Acylation;
With N-chloro-succinimide; thio-xanthene-9-one; In acetonitrile; at 20 ℃; for 7h; Irradiation;
Multi-step reaction with 2 steps
1: dihydrogen peroxide / 1 h / 10 - 40 °C
2: hydrogenchloride; zinc(II) chloride / water / 60 °C
With hydrogenchloride; dihydrogen peroxide; zinc(II) chloride; In water;
4-fluorobenzylic alcohol
459-56-3

4-fluorobenzylic alcohol

4-fluorobenzoyl chloride
403-43-0

4-fluorobenzoyl chloride

Conditions
Conditions Yield
With trichloroisocyanuric acid; In dichloromethane; at 20 ℃; for 120h; Inert atmosphere;
With trichloroisocyanuric acid; In dichloromethane; at 20 ℃; Inert atmosphere;
With trichloroisocyanuric acid; In dichloromethane; at 20 ℃; Inert atmosphere;
4-Fluorobenzoic acid
456-22-4

4-Fluorobenzoic acid

4-fluoro-1-trichloromethylbenzene
402-42-6

4-fluoro-1-trichloromethylbenzene

4-fluorobenzoyl chloride
403-43-0

4-fluorobenzoyl chloride

Conditions
Conditions Yield
With iron(III) oxide; at 140 ℃; for 2.5h; Autoclave;
97.3%
4-Amino-2-chloropyridine
14432-12-3

4-Amino-2-chloropyridine

4-Fluorobenzoic acid
456-22-4

4-Fluorobenzoic acid

4-fluorobenzoyl chloride
403-43-0

4-fluorobenzoyl chloride

Conditions
Conditions Yield
With thionyl chloride; In toluene; at 0 - 20 ℃; for 1h; Inert atmosphere;
N,N-dimethyl-4-fluorobenzamide
24167-56-4

N,N-dimethyl-4-fluorobenzamide

4-fluorobenzoyl chloride
403-43-0

4-fluorobenzoyl chloride

Conditions
Conditions Yield
With iodine; N,N-dimethyl-formamide; phosphorus trichloride; In 1,2-dichloro-ethane; at 100 ℃; for 12h; Schlenk technique; Sealed tube;
92%
2-amino-4-methoxy-benzothiazole-7-carboxylic acid methyl ester

2-amino-4-methoxy-benzothiazole-7-carboxylic acid methyl ester

2-(4-fluoro-benzoylamino)-4-methoxy-benzothiazole-7-carboxylic acid methyl ester

2-(4-fluoro-benzoylamino)-4-methoxy-benzothiazole-7-carboxylic acid methyl ester

4-fluorobenzoyl chloride
403-43-0

4-fluorobenzoyl chloride

Conditions
Conditions Yield
91%

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