40843-46-7

Basic information

• Product Name: 1-CHLORO-4-(4-METHOXYPHENOXY)BENZENE
• Synonyms: 1-CHLORO-4-(4-METHOXYPHENOXY)BENZENE;4-(4-Chlorophenoxy)Methoxybenzene
• CAS NO: 40843-46-7
• Molecular Formula: C₁₃H₁₁ClO₂
• Molecular Weight: 234.67824
• Mol File: 40843-46-7.mol
• Article Data: 25

Chemical Properties

• Boiling Point: 325.174°C at 760 mmHg
• Flash Point: 121.603°C
• Appearance: /
• Density: 1.198g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.57
• CAS DataBase Reference: 1-CHLORO-4-(4-METHOXYPHENOXY)BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CHLORO-4-(4-METHOXYPHENOXY)BENZENE(40843-46-7)
• EPA Substance Registry System: 1-CHLORO-4-(4-METHOXYPHENOXY)BENZENE(40843-46-7)

Safety Data

• Hazardous Substances Data: 40843-46-7(Hazardous Substances Data)

Usage

Synonyms

4-Chloro-2-(4-methoxyphenoxy)chlorobenzene

Chemical Class

Chlorinated aromatic compound

Functional Groups

Chloro and methoxy

Structure

A phenyl ring with a chloro group at the 1st position and a methoxy group attached to a second phenyl ring at the 4th position

Applications

a. Intermediate in the synthesis of pharmaceuticals and agrochemicals
b. Precursor in the manufacturing of dyes, pigments, and polymers

Hazards

a. Harmful if ingested
b. Prolonged exposure may cause skin and eye irritation

Safety Precautions

Handle with care and follow proper safety protocols to minimize exposure risks

InChI:InChI=1/C13H11ClO2/c1-15-11-6-8-13(9-7-11)16-12-4-2-10(14)3-5-12/h2-9H,1H3

Upstream product

• 104-92-7 1-bromo-4-methoxy-benzene 
• 1121-74-0 potassium 4-chlorophenoxide 
• 106-48-9 4-chloro-phenol 
• 106-46-7 para-dichlorobenzene 
• 150-76-5 4-methoxy-phenol 
• 104-94-9 4-methoxy-aniline 
• 584-08-7 potassium carbonate 
• 12775-96-1 copper 
• 637-87-6 1-Chloro-4-iodobenzene 
• 696-62-8 para-iodoanisole 
• 100-66-3 methoxybenzene 
• 59696-06-9 bis(4-chlorophenyl)iodonium tosylate 
• 1428064-54-3 4-chlorophenyl(2,4-dimethoxyphenyl)iodonium tosylate 
• 73178-07-1 -p-chlorobenzene 

Downstream Products

• 21567-18-0 4-(4-chlorophenoxy)phenol 
• 1198149-99-3 4-{(2S)-2-[4-(4-chlorophenoxy)phenoxymethyl]pyrrolidin-1-yl}butyric acid p-toluenesulfonate 
• 1198149-97-1 ethyl 4-{(2S)-2-[4-(4-chlorophenoxy)phenoxymethyl]pyrrolidin-1-yl}butyrate 
• 929915-58-2 4-{(S)-2-(4-(4-chlorophenoxy)phenoxymethyl)pyrrolidin-1-yl}-1-butyric acid hydrochloride 
• 929917-42-0 (S)-2-[4-(4-chlorophenoxy)phenoxymethyl]pyrrolidine-1-carboxylic acid tert-butyl ester 
• 26129-31-7 4-(4-Chlorophenoxy)-phenoxyacetic acid 
• 59621-52-2 2-[4-(4-chloro-phenoxy)-phenoxy]-ethanol 
• 65560-93-2 2-(4-(4-Chlorphenoxy)-phenoxy)-ethylamin 
• 59621-66-8 2-[4-(4-Chloro-phenoxy)-phenoxy]-N-(2-hydroxy-ethyl)-2-methyl-propionamide 
• 59621-54-4 Methanesulfonic acid 2-[4-(4-chloro-phenoxy)-phenoxy]-2-methyl-propyl ester 
• 59621-59-9 2-[4-(4-Chlorophenoxy)-phenoxy]-ethyl mesylate 
• 59621-73-7 4-(4-Chlorphenoxy)-phenoxy-acetamidoxim 
• 59621-72-6 2-{2-[4-(4-Chloro-phenoxy)-phenoxy]-ethylamino}-ethanol 
• 59621-82-8 4-(4-chlorophenoxy)phenoxyacetic acid chloride 

Relevant articles and documents

CoII Immobilized on Aminated Magnetic-Based Metal–Organic Framework: An Efficient Heterogeneous Nanostructured Catalyst for the C–O Cross-Coupling Reaction in Solvent-Free Conditions

Abstract: In this paper, we report the synthesis of Fe3O4?AMCA-MIL53(Al)-NH2-CoII NPs based on the metal–organic framework structures as a magnetically separable and environmentally friendly heterogeneous nanocatalyst. The prepared nanostructured catalyst efficiently promotes the C–O cross-coupling reaction in solvent-free conditions without the need for using toxic solvents and/or expensive palladium catalyst. Graphic Abstract: [Figure not available: see fulltext.].

Cu(I)-PNF, an organic-based nanocatalyst, catalyzed C-O and C-S cross-coupling reactions

Peptide nanofiber has been prepared via a self-assembly protocol and decorated with Cu(I) to prepare a nanostructural catalyst. The catalytic activity of this prepared nanomaterial (Cu(I)-PNF) was examined in C-O and C-S cross-coupling reactions. Compared with conventional copper-ligand catalytic systems, CuNP-PNF has unique advantages such as water solubility, high efficiency, and low cost, which makes it a highly efficient and beneficial catalyst to reuse in cross-coupling reactions.

Simple N-Heterocyclic Carbenes as Ligands in Ullmann-Type Ether and Thioether Formations

A simple N-heterocyclic carbene (NHC) derived from 1-methyl-3-ethylimidazolium tetrafluoroborate was found to be an efficient ligand for a range of copper-catalyzed cross-coupling reactions, leading to the formation of aromatic ethers and thioethers. (Figure presented.) .