41373-39-1

Basic information

• Product Name: 2-PiperidineMethanol, (2S)-
• Synonyms: 2-PiperidineMethanol, (2S)-;(S)-Piperidin-2-ylMethanol;(2S)-2-PiperidineMethanol HCl
• CAS NO: 41373-39-1
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 115.17352
• Mol File: 41373-39-1.mol

Chemical Properties

• Melting Point: 66-68 °C
• Boiling Point: 221.2°C at 760 mmHg
• Flash Point: 90.9°C
• Appearance: /
• Density: 0.951g/cm³
• Vapor Pressure: 0.0225mmHg at 25°C
• Refractive Index: 1.451
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 15.08±0.10(Predicted)
• CAS DataBase Reference: 2-PiperidineMethanol, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PiperidineMethanol, (2S)-(41373-39-1)
• EPA Substance Registry System: 2-PiperidineMethanol, (2S)-(41373-39-1)

Safety Data

• Hazardous Substances Data: 41373-39-1(Hazardous Substances Data)

Usage

Uses

Used in Organic Chemistry:
2-Piperidinemethanol, (2S)is used as a building block for the synthesis of various organic compounds. Its unique structure allows for the creation of a wide range of molecules with different properties and applications.
Used in Pharmaceutical Industry:
2-Piperidinemethanol, (2S)is used as an intermediate in the production of pharmaceuticals. Its chiral nature makes it a valuable component in the development of enantiomerically pure drugs, which can have improved efficacy and reduced side effects compared to their racemic counterparts.
Used in Chiral Synthesis:
2-Piperidinemethanol, (2S)is used as a chiral auxiliary in asymmetric synthesis. Its (2S)configuration can be used to induce chirality in other molecules, leading to the formation of enantiomerically pure products. This is particularly important in the synthesis of complex organic molecules and pharmaceuticals, where the stereochemistry of the product can significantly impact its biological activity.

InChI:InChI=1/C6H13NO/c8-5-6-3-1-2-4-7-6/h6-8H,1-5H2/t6-/m0/s1

Upstream product

• 141-78-6 ethyl acetate 
• 3433-37-2 piperidin-2-ylmethanol 
• 171561-66-3 (-)-(2R)-[(2S)-(hydroxymethyl)piperidin-1-yl]-2-phenylethanol 
• 212557-00-1 (S)-2-hydroxymethyl-piperidine-1-carboxylic acid benzyl ester 
• 28697-07-6 N-benzyloxycarbonyl D/L-pipecolinic acid 
• 28697-11-2 (S)-1-(carbobenzyloxy)-2-piperidinecarboxylic acid 
• 76700-85-1 6-Chlor-5-oxo-hexancarbonsaeuremethylester 
• 88817-74-7 (S)-3,4-Dihydro-2H-pyridine-1,2-dicarboxylic acid dimethyl ester 
• 4043-87-2 pipecolic Acid 
• 3105-95-1 pipecolinic acid 
• 929917-69-1 (S)-(+)-piperidine-2-methanol hydrochloride 
• 15890-00-3 dimethyl β-oxopimelate 
• 261963-32-0 (-)-4-[(3S,5R)-6-oxo-5-phenylmorpholin-3-yl]butanoic acid methyl ester 
• 171561-59-4 (-)-5-oxo-6-[(R)-(phenyl)(phenylmethoxycarbonylamino)acetoxy]hexanoic acid methyl ester 

Downstream Products

• 353764-18-8 (S)-2-hydroxymethyl-1-(2-iodobenzoyl)piperidine 
• 353764-19-9 (S,E)-methyl 3-[1-(2-iodobenzoyl)piperidin-2-yl]acrylate 
• 1191240-43-3 ((S)-1-(2-trifluoromethyl-phenylsulfonyl)piperidin-2-yl)methanol 
• 1072354-75-6 {(2S)-1-[(4-methoxy-2,6-dimethylphenyl)sulfonyl]piperidin-2-yl}methanol 
• 212557-00-1 (S)-2-hydroxymethyl-piperidine-1-carboxylic acid benzyl ester 
• 212556-95-1 (S)-N-(benzyloxycarbonyl)-2-formylpiperidine 
• 150521-32-7 (S)-1-N-Boc-piperidine-2-al 
• 1072354-77-8 ({(2S)-1-[(4-methoxy-2,6-dimethylphenyl)sulfonyl]piperidin-2-yl}methoxy)acetic acid 

Relevant articles and documents

Protecting-Group-Directed Regio- and Stereoselective Oxymercuration-Demercuration: Synthesis of Piperidine Alkaloids Containing 1,2- and 1,3-Amino Alcohol Units

An efficient synthesis of naturally occurring 1,2- and 1,3-amino alcohol unit containing 2-substituted piperidine alkaloids and their analogues has been developed from l -pipecolinic acid. The protocol describes the regio- and stereoselective oxymercuration-demercuration of 2-alkenyl piperidines based on protecting groups to give piperidine alkaloids as a key step.

2-(1,2,3-TRIAZOL-2-YL)BENZAMIDE AND 3-(1,2,3-TRIAZOL-2-YL)PICOLINAMIDE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS

The present invention relates to 2-(1,2,3-triazol-2-yl)benzamide and 3-(1,2,3-triazol-2-yl)picolinamide derivatives of formula (I) wherein Ar1, Q, and R1 to R5 are as described in the description, to their preparation, to

2-(1,2,3-TRIAZOL-2-YL)BENZAMIDE AND 3-(1,2,3-TRIAZOL-2-YL)PICOLINAMIDE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS

The present invention relates to 2-(1,2,3-triazol-2-yl)benzamide and 3-(1,2,3-triazol-2- yl)picolinamide derivatives of formula (I) Formula (I) wherein Ar1, Q, and R1 to R5 are as described in the description, to their pre

A concise diastereoselective approach to (+)-dexoxadrol, (-)-epi-dexoxadrol, (-)-conhydrine and (+)-lentiginosine from (-)-pipecolinic acid

A new diastereoselective pathway for the total synthesis of (+)-dexoxadrol, first asymmetric synthesis of (-)-epi-dexoxadrol and formal synthesis of conhydrine and (+)-lentiginosine is presented using commercially available (-)-pipecolinic acid. The key reactions utilized are Sharpless asymmetric dihydroxylation and Wittig reaction. The paper further describes the study of effect of protecting groups on dihydroxylation of a terminal olefin in piperidine ring system.

Henry-Nef reaction: A practical and versatile chiral pool route to 2-substituted pyrrolidine and piperidine alkaloids

The paper describes the synergistic protocol developed by combinatorial Henry and Nef reaction for the synthesis of 2-substituted pyrrolidine and piperidine alkaloids containing 1,3-aminoketone and 1,3-amino alcohol units. The utility of the protocol is demonstrated by asymmetric synthesis of 12 natural products of which asymmetric synthesis of (-)-N-methylpelletierine is presented for the first time. The one-carbon homologation described also provides an alternate route for the synthesis of key intermediates homoprolinol and homopipecolinol used as synthetic precursors for several alkaloids and construction of β-amino acids from α-amino acids.

Stereoselective syntheses of L-pipecolic acid and (2S,3S)-3- hydroxypipecolic acid from a chiral n-imino-2-phenyl-1,2-dihydropyridine intermediate

"Chemical Equation Presented" Stereoselective syntheses of L-pipecolic acid and (2S,3S)3-hydroxypipecolic acid were achieved from a chiral AMmino-2-phenyl-l,2-dihydropyridine intermediate. The 3-hydroxy substituent of the latter amino acid was introduced, by hetero-Diels-Alder reaction of singlet, oxygen with the 1,2-dihydropyridine.

Substituted Pyrimidine and Triazine Compounds

Substituted pyrimidine and triazine compounds corresponding to formula I wherein R1, R2, R3, R4a, R4b, R5a, R5b, R7, R8, R9a, R9b, R10, R11, A, a, b, s, t, V, W1, W2 and W3 have defined meanings, pharmaceutical compositions comprising such compounds, a process for preparing such compounds, and the use of such compounds and compositions to treat or inhibit pain and/or other disorders or disease states.

Substituted Spiroamine Compounds

Substituted spiroamine compounds corresponding to the formula (I) In which m, n, o, p, Q, r, s, t, R1, R2, R3, R4a, R4b, R5a, R5b, R6a, R6b, R7, R8, R9, R10 and R11 have defined meanings; a process for the preparation of such compounds, pharmaceutical compositions containing such compounds and the use of substituted spiroamines for the treatment or inhibition of pain and/or other conditions mediated by the bradykinin 1 receptor.

Substituted Sulfonamide Compounds

Substituted sulfonamide compounds corresponding to the formula I: processes for the preparation thereof, pharmaceutical composition containing these compounds and the use of substituted sulfonamide compounds for the preparation of pharmaceutical compositions.

Substituted Sulfonamide Compounds

Substituted sulfonamide compounds corresponding to formula I: a process for their preparation, pharmaceutical compositions comprising such compounds, and the use of such substituted sulfonamide compounds in pharmaceutical compositions for the treatment of pain or other disorders or diseases that are mediated at least in part by B1R receptors.