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All total 39 Articles be found
All total 39 Articles be foundSynthesis method of lenvatinib
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, (2021/08/28)
The invention relates to a systhesis method of lenvatinib. The method comprises the following steps: by taking 2-chloro-4-methyl hydroxybenzoate and 4-chloro-7-methoxyquinoline-6-amide as starting raw materials, carrying out substitution reaction to obtain 4-[3-chloro-4-methoxycarbonyl phenoxy]-7-methoxy-6-quinolinecarboxamide, carrying out an alkaline hydrolysis reaction to obtain 4-(3-chloro-4-carboxyphenoxy)-7-methoxy-6-quinolinecarboxamide, carrying out a Curtius rearrangement reaction on the 4-(3-chloro-4-carboxyphenoxy)-7-methoxy-6-quinolinecarboxamide and diphenyl azide phosphate (DPPA), and carrying out a reaction on the obtained product and cyclopropylamine to obtain lenvatinib through a one-pot method. The invention provides a novel method for synthesizing lenvatinib. The method has the advantages of simple reaction steps, simple and easily available raw materials, simple operation and low production cost.
Synthetic method of anti-cancer drug lenvatinib
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Paragraph 0010, (2021/01/25)
The invention provides a synthetic method of an anti-cancer drug lenvatinib. The synthetic method comprises the following steps of synthesis of a compound 2, synthesis of a compound 4, synthesis of acompound 5, synthesis of a compound 6, synthesis of a compound 7, synthesis of a compound 8, synthesis of a compound 9, synthesis of a compound 10, synthesis of a compound 11 and synthesis of a compound 12. Synthesis of a compound 2 is as follows: sequentially adding raw materials of Meldrum's acid (40g, 277.8 mmol) and trimethyl orthoformate (147g, 1.387 mol) into a 500ml of three-neck flask, slowly performing heating to 90 DEG C for reaction under a stirring condition, slowly performing cooling to room temperature under a solution stirring condition after the reaction is finished, performingfiltering after crystallization, recrystallizing a product by using petroleum ether/ethyl acetate according to a ratio of 5: 1, and performing drying to obtain a faint yellow product 2; by improvingthe synthesis method of the anti-cancer drug lenvatinib, the synthesis method has the advantages of reasonable design, simple operation flow, easily available raw materials, stable yield and easinessin industrial production, so that the problems and defects of the synthesis method are effectively solved and overcome.
Preparation method of lenvatinib
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, (2020/05/01)
The invention discloses a preparation method of lenvatinib, which comprises the following steps: by using 4-nitro-2-chlorobenzonitrile as an initial raw material, introducing nitro into molecules forelectron withdrawing, thereby greatly lowering the elect
